Three Research Cores are proposed to facilitate interdisciplinary research into hearing and deafness at the Massachusetts Eye and Ear Infirmary. The Research Center comprises 23 senior investigators and 9 junior investigators, all affiliated with the Eaton-Peabody Laboratory (EPL). They include clinicians and basic scientists, with academic ties to graduate programs and departments at Harvard Medical School and MIT. The Research Base covers a wide range of basic and applied research projects from peripheral mechanics to cortical processing, from in vitro systems to human patients, from animal models to neural nets. The three Cores and the major aims of each include 1) an Engineering Core to design, build, program and maintain data-acquisition systems, custom acoustical devices, and stimulus generation systems, to provide a precision machining service to build custom mechanical devices for a wide variety of research applications, and to share these software and hardware advances with the greater scientific community;2) a Histology-Surgery Core to maintain existing shared facilities, to assist research teams in animal surgery and histological preparation for both light and electron microscopy and to continually enhance the quality of both histological and surgical preparations throughout the center;and 3) an Imaging Core to support digital image-acquisition and analysis, including confocal microscopy, transmission electron microscopy, computer-aided anatomical reconstruction, automation of morphometry, 3-D reconstruction/rendering, analysis of functional imaging data, and to share virtual teaching models with the greater scientific community.

National Institute of Health (NIH)
National Institute on Deafness and Other Communication Disorders (NIDCD)
Center Core Grants (P30)
Project #
Application #
Study Section
Special Emphasis Panel (ZDC1-SRB-Y (58))
Program Officer
Platt, Christopher
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
Massachusetts Eye and Ear Infirmary
United States
Zip Code
Street, Valerie A; Kujawa, Sharon G; Manichaikul, Ani et al. (2014) Resistance to noise-induced hearing loss in 129S6 and MOLF mice: identification of independent, overlapping, and interacting chromosomal regions. J Assoc Res Otolaryngol 15:721-38
Brugeaud, Aurore; Tong, Mingjie; Luo, Li et al. (2014) Inhibition of repulsive guidance molecule, RGMa, increases afferent synapse formation with auditory hair cells. Dev Neurobiol 74:457-66
Parker, Mark A; Cheng, Yen-fu; Kinouchi, Hikaru et al. (2014) An independent construct for conditional expression of atonal homolog-1. Hum Gene Ther Methods 25:1-13
Yin, Yanbo; Liberman, Leslie D; Maison, Stéphane F et al. (2014) Olivocochlear innervation maintains the normal modiolar-pillar and habenular-cuticular gradients in cochlear synaptic morphology. J Assoc Res Otolaryngol 15:571-83
Liberman, M Charles; Liberman, Leslie D; Maison, Stéphane F (2014) Efferent feedback slows cochlear aging. J Neurosci 34:4599-607
Shi, Fuxin; Hu, Lingxiang; Jacques, Bonnie E et al. (2014) ?-Catenin is required for hair-cell differentiation in the cochlea. J Neurosci 34:6470-9
Wang, Le; Devore, Sasha; Delgutte, Bertrand et al. (2014) Dual sensitivity of inferior colliculus neurons to ITD in the envelopes of high-frequency sounds: experimental and modeling study. J Neurophysiol 111:164-81
Chung, Yoojin; Hancock, Kenneth E; Nam, Sung-Il et al. (2014) Coding of electric pulse trains presented through cochlear implants in the auditory midbrain of awake rabbit: comparison with anesthetized preparations. J Neurosci 34:218-31
Wan, Guoqiang; Gómez-Casati, Maria E; Gigliello, Angelica R et al. (2014) Neurotrophin-3 regulates ribbon synapse density in the cochlea and induces synapse regeneration after acoustic trauma. Elife 3:
Chambers, Anna R; Hancock, Kenneth E; Sen, Kamal et al. (2014) Online stimulus optimization rapidly reveals multidimensional selectivity in auditory cortical neurons. J Neurosci 34:8963-75

Showing the most recent 10 out of 97 publications