Section II - Administrative Shell A. Abstract and Key Personnel Three Research Cores are proposed to facilitate interdisciplinary research into hearing and deafness at the Massachusetts Eye and Ear Infirmary. The three Cores and the major aims of each include 1) an Engineering Core to design, build, program and maintain data-acquisition systems, custom acoustical devices, and stimulus generation systems, and to provide a precision machining service to build custom mechanical devices for a wide variety of research applications;2) an Imaging Core to support the needs of Center investigators for digital image-acquisition and analysis, including confocal microscopy, transmission electron microscopy, computer-aided anatomical reconstruction, automation of morphometry, 3-D reconstruction/rendering, and analysis of functional imaging data;and 3) a Histology-Surgery Core to maintain existing shared facilities and assist research teams in animal surgery and histological preparation for both light and electron microscopy. The Administrative Shell for this P30 includes the Program Director and a Grants Manager. Only fractional additional effort level is required to effectively administer this P30, because 1) the Center Investigators, Core Personnel, Program Director and Grants Manager have a long history of productive collaboration, 2) the Program Director is also Co-PI on both Imaging and Histology-Surgery Cores and is an active user of the Engineering Core, and 3) the Grants Manager also handles many pre-award and post-award functions for the numerous R-grants of almost all Center Investigators and is thus thoroughly conversant with all the components of this Center.

National Institute of Health (NIH)
National Institute on Deafness and Other Communication Disorders (NIDCD)
Center Core Grants (P30)
Project #
Application #
Study Section
Special Emphasis Panel (ZDC1-SRB-Y (58))
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
Massachusetts Eye and Ear Infirmary
United States
Zip Code
Street, Valerie A; Kujawa, Sharon G; Manichaikul, Ani et al. (2014) Resistance to noise-induced hearing loss in 129S6 and MOLF mice: identification of independent, overlapping, and interacting chromosomal regions. J Assoc Res Otolaryngol 15:721-38
Brugeaud, Aurore; Tong, Mingjie; Luo, Li et al. (2014) Inhibition of repulsive guidance molecule, RGMa, increases afferent synapse formation with auditory hair cells. Dev Neurobiol 74:457-66
Parker, Mark A; Cheng, Yen-fu; Kinouchi, Hikaru et al. (2014) An independent construct for conditional expression of atonal homolog-1. Hum Gene Ther Methods 25:1-13
Yin, Yanbo; Liberman, Leslie D; Maison, Stéphane F et al. (2014) Olivocochlear innervation maintains the normal modiolar-pillar and habenular-cuticular gradients in cochlear synaptic morphology. J Assoc Res Otolaryngol 15:571-83
Liberman, M Charles; Liberman, Leslie D; Maison, Stéphane F (2014) Efferent feedback slows cochlear aging. J Neurosci 34:4599-607
Shi, Fuxin; Hu, Lingxiang; Jacques, Bonnie E et al. (2014) ?-Catenin is required for hair-cell differentiation in the cochlea. J Neurosci 34:6470-9
Wang, Le; Devore, Sasha; Delgutte, Bertrand et al. (2014) Dual sensitivity of inferior colliculus neurons to ITD in the envelopes of high-frequency sounds: experimental and modeling study. J Neurophysiol 111:164-81
Chung, Yoojin; Hancock, Kenneth E; Nam, Sung-Il et al. (2014) Coding of electric pulse trains presented through cochlear implants in the auditory midbrain of awake rabbit: comparison with anesthetized preparations. J Neurosci 34:218-31
Wan, Guoqiang; Gómez-Casati, Maria E; Gigliello, Angelica R et al. (2014) Neurotrophin-3 regulates ribbon synapse density in the cochlea and induces synapse regeneration after acoustic trauma. Elife 3:
Chambers, Anna R; Hancock, Kenneth E; Sen, Kamal et al. (2014) Online stimulus optimization rapidly reveals multidimensional selectivity in auditory cortical neurons. J Neurosci 34:8963-75

Showing the most recent 10 out of 97 publications