A rate-limiting step for many studies of the nervous system is obtaining and effectively using the sophisticated technical hardware and analytical methods needed for innovative research. These constraints apply as well to studies of neural signal processing in the brain as they do to studies of disordered processing in animal models of hearing or balance deficits. Even if hardware/software systems are available for planned experiments, they inevitably require modification for special purposes or integration with other systems in the laboratory. This Engineering Core aims to solve these electronics and computer problems by providing computer programming and electronics expertise to researchers in the Center for Hearing and Balance. The cumulative expertise of our staff makes it possible for our research faculty to focus on experiments and not technology development and allows rapid progress in the use of new technologies. During the past five years this core has developed new behavioral interfaces, new telemetric recording equipment for use in awake and unrestrained animals, and new software for on-line optimization of neuron models. We have adapted multi-single unit recording techniques for our uses and have provided support for routine problems of technology usage.

Agency
National Institute of Health (NIH)
Type
Center Core Grants (P30)
Project #
5P30DC005211-13
Application #
8716724
Study Section
Special Emphasis Panel (ZDC1)
Project Start
Project End
Budget Start
Budget End
Support Year
13
Fiscal Year
2014
Total Cost
Indirect Cost
Name
Johns Hopkins University
Department
Type
DUNS #
City
Baltimore
State
MD
Country
United States
Zip Code
21218
Wu, Jingjing Sherry; Young, Eric D; Glowatzki, Elisabeth (2016) Maturation of Spontaneous Firing Properties after Hearing Onset in Rat Auditory Nerve Fibers: Spontaneous Rates, Refractoriness, and Interfiber Correlations. J Neurosci 36:10584-10597
Ward, Bryan K; Gold, Daniel R (2016) Tinnitus, Oscillopsia, and Hyperventilation-Induced Nystagmus: Vestibular Paroxysmia. Open J Clin Med Case Rep 2:
Campbell, Dean P; Chrysostomou, Elena; Doetzlhofer, Angelika (2016) Canonical Notch signaling plays an instructive role in auditory supporting cell development. Sci Rep 6:19484
Martinez-Monedero, Rodrigo; Liu, Chang; Weisz, Catherine et al. (2016) GluA2-Containing AMPA Receptors Distinguish Ribbon-Associated from Ribbonless Afferent Contacts on Rat Cochlear Hair Cells. eNeuro 3:
Hageman, Kristin N; Kalayjian, Zaven K; Tejada, Francisco et al. (2016) A CMOS Neural Interface for a Multichannel Vestibular Prosthesis. IEEE Trans Biomed Circuits Syst 10:269-79
Lin, Chun-Chieh; Potter, Christopher J (2016) Editing Transgenic DNA Components by Inducible Gene Replacement in Drosophila melanogaster. Genetics 203:1613-28
Abt, Nicholas B; Lehar, Mohamed; Guajardo, Carolina Trevino et al. (2016) Intratympanic Iodine Contrast Injection Diffuses Across the Round Window Membrane Allowing for Perilymphatic CT Volume Acquisition Imaging. Otol Neurotol 37:403-7
Lin, Chun-Chieh; Potter, Christopher J (2016) Non-Mendelian Dominant Maternal Effects Caused by CRISPR/Cas9 Transgenic Components in Drosophila melanogaster. G3 (Bethesda) :
Diao, Fengqiu; Ironfield, Holly; Luan, Haojiang et al. (2015) Plug-and-play genetic access to drosophila cell types using exchangeable exon cassettes. Cell Rep 10:1410-21
Ward, Bryan K; Roberts, Dale C; Della Santina, Charles C et al. (2015) Vestibular stimulation by magnetic fields. Ann N Y Acad Sci 1343:69-79

Showing the most recent 10 out of 125 publications