The HEI Core Center for Hearing Research aims to support and facilitate research, foster collaborations and set new research directions in the following two areas: 1) engineering, and 2) imaging/morphology. Core B: Engineering - The Engineering Core will develop and maintain expertise in rapidly changing technologies to support new and innovative enabling technologies for scientific applications: digital signal processing (DSP), communication interfaces, and controllers. The Core will also interact with project-specific engineers to provide core hardware and software components in these areas for integration into research projects. Core C: Imaging and Morphology - aims to provide state-of-the-art, intravital imaging, morphology and microscopy services and training to HEI scientists. Such services include inspection and maintenance of all imaging equipment, image storage and analysis, morphometry and training. The addition of a histology technician will help towards the achievement of this objective. The addition of a full time confocal technician is particularly important since we are in the process of purchasing two new Laser Scanning Confocal microscopes with increased functionality to replace the one we originally purchased 10 years ago. The Core will perform inspection and maintenance of all imaging and tissue processing equipment. The Core will also encourage collaboration and dissemination of information about advances in the field of imaging.

Agency
National Institute of Health (NIH)
Institute
National Institute on Deafness and Other Communication Disorders (NIDCD)
Type
Center Core Grants (P30)
Project #
5P30DC006276-09
Application #
8134257
Study Section
Special Emphasis Panel (ZDC1-SRB-L (43))
Program Officer
Platt, Christopher
Project Start
2003-08-01
Project End
2013-07-31
Budget Start
2011-08-01
Budget End
2012-07-31
Support Year
9
Fiscal Year
2011
Total Cost
$261,835
Indirect Cost
Name
House Research Institute
Department
Type
DUNS #
062076989
City
Los Angeles
State
CA
Country
United States
Zip Code
90057
Wu, Siva; Baum, Marc M; Kerwin, James et al. (2014) Biofilm-specific extracellular matrix proteins of nontypeable Haemophilus influenzae. Pathog Dis 72:143-60
Schaudinn, Christoph; Stoodley, Paul; Hall-Stoodley, Luanne et al. (2014) Death and transfiguration in static Staphylococcus epidermidis cultures. PLoS One 9:e100002
Forristall, Caryl A; Stellabotte, Frank; Castillo, Aldo et al. (2014) Embryological manipulations in the developing Xenopus inner ear reveal an intrinsic role for Wnt signaling in dorsal-ventral patterning. Dev Dyn 243:1262-74
Wu, Siva; Li, Xiaojin; Gunawardana, Manjula et al. (2014) Beta- lactam antibiotics stimulate biofilm formation in non-typeable haemophilus influenzae by up-regulating carbohydrate metabolism. PLoS One 9:e99204
Kitani, Rei; Park, Channy; Kalinec, Federico (2013) Microdomains shift and rotate in the lateral wall of cochlear outerĀ hairĀ cells. Biophys J 104:8-18
Oh, Sejo; Woo, Jeong-Im; Lim, David J et al. (2012) ERK2-dependent activation of c-Jun is required for nontypeable Haemophilus influenzae-induced CXCL2 upregulation in inner ear fibrocytes. J Immunol 188:3496-505
Hajagos, Bettina E; Turetzky, Jay M; Peng, Eric D et al. (2012) Molecular dissection of novel trafficking and processing of the Toxoplasma gondii rhoptry metalloprotease toxolysin-1. Traffic 13:292-304
Schaudinn, Christoph; Gorur, Amita; Webster, Paul et al. (2012) Quantification by energy dispersive x-ray spectroscopy of alendronate in the diseased jaw bone of patients with bisphosphonate-related jaw osteonecrosis. Oral Surg Oral Med Oral Pathol Oral Radiol 114:480-6
Bricaud, Olivier; Collazo, Andres (2011) Balancing cell numbers during organogenesis: Six1a differentially affects neurons and sensory hair cells in the inner ear. Dev Biol 357:191-201
Kitani, Rei; Kalinec, Federico (2011) Investigating outer hair cell motility with a combination of external alternating electrical field stimulation and high-speed image analysis. J Vis Exp :

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