Many Monell scientists conduct studies with animals and need to characterize their chemosensory phenotypes. They will benefit from the Phenotyping Core in the following ways. 1) This Core will provide a centralized resource of equipment and supplies that will receive dedicated support and regular maintenance. The Core will also centralize labor-intensive tasks, such as making equipment for preference tests. Studies will be designed and/or conducted by Core personnel with specialized expertise in phenotyping techniques. This will be more efficient than replicating these techniques and personnel in individual laboratories. Regular use and service will ensure that equipment is always operational and available for experimentation. 2) The Core will provide access to equipment and facilities (e.g., LabMaster, surgical facility) that are not practical to maintain in individual laboratories. The Core will offer a range of services and experimental designs that are not available in individual laboratories. 3) Scientists with no experience in animal phenotyping will receive training and will have access to equipment and expertise of the Core. This will facilitate their research and help them to collect preliminary data for grant applications. 4) This Research Core will be an integral component of the Core Center. Interactions between the Phenotyping Core and other Research Cores will facilitate collaborative and interdisciplinary studies that are often not feasible for individual laboratories. For example, the Phenotyping and Histology Cores will be used to characterize genetically engineered mice generated from constructs produced using the Molecular Biology Core. In forward genetics studies, the same animals will be examined using the Phenotyping and Genotyping Cores, and the data obtained will be used for chromosomal mapping studies. We estimate that 9 of the 13 R01 grants in our Research Base will use services provided by this Core at moderate to extensive levels. We also expect that 11 current faculty research groups at Monell will use the services provided by this Core. As a result, the Phenotyping Core will improve the efficiency and quality of animal model studies at the Center, accelerate existing NIDCD-funded projects, and advance translation of the results into benefits for public health.

National Institute of Health (NIH)
National Institute on Deafness and Other Communication Disorders (NIDCD)
Center Core Grants (P30)
Project #
Application #
Study Section
Special Emphasis Panel (ZDC1)
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
Monell Chemical Senses Center
United States
Zip Code
Xu, Mingang; Horrell, Jeremy; Snitow, Melinda et al. (2017) WNT10A mutation causes ectodermal dysplasia by impairing progenitor cell proliferation and KLF4-mediated differentiation. Nat Commun 8:15397
Sukumaran, Sunil K; Lewandowski, Brian C; Qin, Yumei et al. (2017) Whole transcriptome profiling of taste bud cells. Sci Rep 7:7595
Hariri, Benjamin M; McMahon, Derek B; Chen, Bei et al. (2017) Flavones modulate respiratory epithelial innate immunity: Anti-inflammatory effects and activation of the T2R14 receptor. J Biol Chem 292:8484-8497
Ren, Wenwen; Aihara, Eitaro; Lei, Weiwei et al. (2017) Transcriptome analyses of taste organoids reveal multiple pathways involved in taste cell generation. Sci Rep 7:4004
Tordoff, Michael G; Pearson, Jordan A; Ellis, Hillary T et al. (2017) Does eating good-tasting food influence body weight? Physiol Behav 170:27-31
Guo, Yiran; Hwang, Liang-Dar; Li, Jiankang et al. (2017) Genetic analysis of impaired trimethylamine metabolism using whole exome sequencing. BMC Med Genet 18:11
Tomassini Barbarossa, Iole; Ozdener, M Hakan; Melis, Melania et al. (2017) Variant in a common odorant-binding protein gene is associated with bitter sensitivity in people. Behav Brain Res 329:200-204
Mennella, Julie A; Mathew, Phoebe S; Lowenthal, Elizabeth D (2017) Use of Adult Sensory Panel to Study Individual Differences in the Palatability of a Pediatric HIV Treatment Drug. Clin Ther 39:2038-2048
Ibarra-Soria, Ximena; Nakahara, Thiago S; Lilue, Jingtao et al. (2017) Variation in olfactory neuron repertoires is genetically controlled and environmentally modulated. Elife 6:
Bobowski, Nuala; Reed, Danielle R; Mennella, Julie A (2016) Variation in the TAS2R31 bitter taste receptor gene relates to liking for the nonnutritive sweetener Acesulfame-K among children and adults. Sci Rep 6:39135

Showing the most recent 10 out of 77 publications