Abstract

The Immunoassay Core (IA) provides Affiliate Investigators of the DERC with assays of peptides (insulin, proinsulin, C-peptide, Leptin, glucagon, pancreatic polypeptide) and antibodies (GAD65, ICA512, Insulin autoantibodies), performed under highly standardized conditions and with economies of scale unavailable to the individual investigator. During the past five-year funding period, the IA Core completed 18 projects for 16 Affiliate Investigators. At the present time, more than 35 projects are being supported for 34 Investigators. Work supported by the IA Core has, in this project period, resulted in over 215 publications in peer-review journals, and 19 book chapters. For the next project period, the IA Core will support at least 35 projects of 30 Affiliate Investigators. Assays are cost-effective for individual investigators; $5.00 is charged for measurements of insulin, C-peptide, $5.15 is charged for measurement of pancreatic polypeptide, glucagon, or proinsulin, GAD65 antibody and ICA512 (IA2) antibody level determinations, Leptin is charged at $6.40 and insulin autoantibody determination is charged at $7.40. In addition the Core laboratory provides insulin and glucagon radiolabeled tracer to Affiliate Investigators.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Center Core Grants (P30)
Project #
2P30DK017047-27
Application #
6612277
Study Section
Special Emphasis Panel (ZDK1-GRB-7 (O1))
Project Start
2002-12-01
Project End
2007-11-30
Budget Start
Budget End
2003-11-30
Support Year
27
Fiscal Year
2003
Total Cost
$138,172
Indirect Cost

  Institution

Name
University of Washington
Department
Type
DUNS #
605799469
City
Seattle
State
WA
Country
United States
Zip Code
98195

  Publications

Sosenko, Jay M; Geyer, Susan; Skyler, Jay S et al. (2018) The influence of body mass index and age on C-peptide at the diagnosis of type 1 diabetes in children who participated in the diabetes prevention trial-type 1. Pediatr Diabetes 19:403-409
Smith, Laura B; Liu, Xiang; Johnson, Suzanne Bennett et al. (2018) Family adjustment to diabetes diagnosis in children: Can participation in a study on type 1 diabetes genetic risk be helpful? Pediatr Diabetes 19:1025-1033
Kang, Inkyung; Chang, Mary Y; Wight, Thomas N et al. (2018) Proteoglycans as Immunomodulators of the Innate Immune Response to Lung Infection. J Histochem Cytochem 66:241-259
Rubinow, Katya B; Houston, Barbara; Wang, Shari et al. (2018) Androgen receptor deficiency in monocytes/macrophages does not alter adiposity or glucose homeostasis in male mice. Asian J Androl 20:276-283
Espeland, Mark A; Carmichael, Owen; Hayden, Kathleen et al. (2018) Long-term Impact of Weight Loss Intervention on Changes in Cognitive Function: Exploratory Analyses from the Action for Health in Diabetes Randomized Controlled Clinical Trial. J Gerontol A Biol Sci Med Sci 73:484-491
Banks, W A; Farr, S A; Salameh, T S et al. (2018) Triglycerides cross the blood-brain barrier and induce central leptin and insulin receptor resistance. Int J Obes (Lond) 42:391-397
Bingley, Polly J; Wherrett, Diane K; Shultz, Ann et al. (2018) Type 1 Diabetes TrialNet: A Multifaceted Approach to Bringing Disease-Modifying Therapy to Clinical Use in Type 1 Diabetes. Diabetes Care 41:653-661
RISE Consortium (2018) Metabolic Contrasts Between Youth and Adults With Impaired Glucose Tolerance or Recently Diagnosed Type 2 Diabetes: I. Observations Using the Hyperglycemic Clamp. Diabetes Care 41:1696-1706
Olivo, Robert E; Davenport, Clemontina A; Diamantidis, Clarissa J et al. (2018) Obesity and synergistic risk factors for chronic kidney disease in African American adults: the Jackson Heart Study. Nephrol Dial Transplant 33:992-1001
Uusitalo, Ulla; Lee, Hye-Seung; Andrén Aronsson, Carin et al. (2018) Early Infant Diet and Islet Autoimmunity in the TEDDY Study. Diabetes Care 41:522-530

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