The Diabetes Research Center at the University of Washington has existed for 38 years as part of a national program supported by NIH. It acts as the focal point and umbrella for diabetes research in the Greater Seattle area W .h the goal of promoting an environment of collaborative research on diabetes, obesity and related disorders by (a) providing support to affiliate investigators through its biomedical research cores, (b) sponsoring an enrichment program comprising lectures and symposia to Inform the community of the latest developments in the area, (c) conducting a small pilot and feasibility program that provides grant support for new investigators in diabetes research and to established investigators In other disciplines, (d) ensuring the development of young investigators by providing fellowships for salary support and training In Its research cores, and (e) developing new research methods and technologies for use by investigators. To accomplish this goal, the Center is organized around six biomedical research cores (Cell Function Analysis Core, Cellular and Molecular Imaging Core, Human Studies Core, Immunology and Inflammation Core, Quantitative and Functional Proteomics Core, and Viral Vector and Transgenic Mouse Core) and an Administrative Core that also administers the Pilot and Feasibility Program and the Enrichment Program. Along with the commitment of the University of Washington and other Seattle institutions of research space and additional financial support, the Diabetes Research Center is a dynamic and constantly evolving center that supports 95 Seattle-based affiliate investigators who are making important scientific contributions in the areas of (a) etiology, pathogenesis and treatment of type 1 diabetes, (b) pathophysiology and treatment of type 2 diabetes, (c) obesity and regulation of body weight/composition, (d) microvascular complications of diabetes, (e) inflammation, macrovascular and other complications of diabetes, and (f) clinical trials and large-scale epidemiologic studies.

National Institute of Health (NIH)
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Center Core Grants (P30)
Project #
Application #
Study Section
Special Emphasis Panel (ZDK1-GRB-S (O2))
Program Officer
Hyde, James F
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
University of Washington
Internal Medicine/Medicine
Schools of Medicine
United States
Zip Code
Ikizler, Halil O; Zelnick, Leila; Ruzinski, John et al. (2016) Dietary Acid Load is Associated With Serum Bicarbonate but not Insulin Sensitivity in Chronic Kidney Disease. J Ren Nutr 26:93-102
Tang, Chongren; Houston, Barbara A; Storey, Carl et al. (2016) Both STAT3 activation and cholesterol efflux contribute to the anti-inflammatory effect of apoA-I/ABCA1 interaction in macrophages. J Lipid Res 57:848-57
Ronsein, Graziella E; Hutchins, Patrick M; Isquith, Daniel et al. (2016) Niacin Therapy Increases High-Density Lipoprotein Particles and Total Cholesterol Efflux Capacity But Not ABCA1-Specific Cholesterol Efflux in Statin-Treated Subjects. Arterioscler Thromb Vasc Biol 36:404-11
Kanter, Jenny E; Bornfeldt, Karin E (2016) Impact of Diabetes Mellitus. Arterioscler Thromb Vasc Biol 36:1049-53
Shimizu-Albergine, Masami; Van Yserloo, Brian; Golkowski, Martin G et al. (2016) SCAP/SREBP pathway is required for the full steroidogenic response to cyclic AMP. Proc Natl Acad Sci U S A 113:E5685-93
Neal, Adam S; Rountree, Austin M; Radtke, Jared R et al. (2016) A method for high-throughput functional imaging of single cells within heterogeneous cell preparations. Sci Rep 6:39319
Rountree, Austin; Karkamkar, Amit; Khalil, Gamal et al. (2016) BaroFuse, a novel pressure-driven, adjustable-throughput perfusion system for tissue maintenance and assessment. Heliyon 2:e00210
Aroda, Vanita R; Edelstein, Sharon L; Goldberg, Ronald B et al. (2016) Long-term Metformin Use and Vitamin B12 Deficiency in the Diabetes Prevention Program Outcomes Study. J Clin Endocrinol Metab 101:1754-61
Bornfeldt, Karin E (2016) Does Elevated Glucose Promote Atherosclerosis? Pros and Cons. Circ Res 119:190-3
Willard, Joshua R; Barrow, Breanne M; Zraika, Sakeneh (2016) Improved glycaemia in high-fat-fed neprilysin-deficient mice is associated with reduced DPP-4 activity and increased active GLP-1 levels. Diabetologia :

Showing the most recent 10 out of 1030 publications