Morphology and Image Analysis Core (MIAC) The objectives of the core are to: 1. Provide consultation and training In microscopy and optical Image analysis for MDRC investigators Provide access to senior personnel highly skilled in microscopy and optical image analysis for MDRC Investigators 3. Provide access to state-of-the-art instrumentation for microscopy and optical image analysis for MDRC Investigators 4. Develop and/or implement new technologies for microscopy and optical Image analysis beneficial to MDRC Investigators. The MIAC remains focused on providing state-of-the-art quantitative morphological analysis of fixed and living cells for MDRC Investigators working on diabetes, its complications, and related endocrine and metabolic disorders. The Core provides service, consultation, collaboration and access to instrumentation for a variety of microscopic and analytic techniques. The Core focuses on light microscopic and confocal analysis of fixed and living cells using immunocyto-chemlstry, visualization of fluorescent proteins and use of fluorescent reporter probes such as Ca2+ and mitochondrial function. The Core's major instruments are three confocal microscopes and a widefield inverted fluorescence microscope, along with the Instrumentation and software to carry out quantitative and other. The capabilities of the MIAC have been substantially augmented during the current funding cycle.

Public Health Relevance

The research supported by this Core is relevant to public health because it will increase our understanding of the cellular and morphologic events that underlie the development of diabetes and its complications, and hence will facilitate the development of improved diagnostic, prevention and treatment strategies.

National Institute of Health (NIH)
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Center Core Grants (P30)
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University of Michigan Ann Arbor
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Zick, Suzanna M; Turgeon, D Kim; Ren, Jianwei et al. (2015) Pilot clinical study of the effects of ginger root extract on eicosanoids in colonic mucosa of subjects at increased risk for colorectal cancer. Mol Carcinog 54:908-15
Krebs, Christopher J; Zhang, Deqiang; Yin, Lei et al. (2014) The KRAB zinc finger protein RSL1 modulates sex-biased gene expression in liver and adipose tissue to maintain metabolic homeostasis. Mol Cell Biol 34:221-32
Simon, Becky R; Learman, Brian S; Parlee, Sebastian D et al. (2014) Sweet taste receptor deficient mice have decreased adiposity and increased bone mass. PLoS One 9:e86454
Vassas, Thomas J; Burghardt, Kyle J; Ellingrod, Vicki L (2014) Pharmacogenomics of sterol synthesis and statin use in schizophrenia subjects treated with antipsychotics. Pharmacogenomics 15:61-7
Cawthorn, William P; Scheller, Erica L; Learman, Brian S et al. (2014) Bone marrow adipose tissue is an endocrine organ that contributes to increased circulating adiponectin during caloric restriction. Cell Metab 20:368-75
Rothberg, Amy E; McEwen, Laura N; Kraftson, Andrew T et al. (2014) The impact of weight loss on health-related quality-of-life: implications for cost-effectiveness analyses. Qual Life Res 23:1371-6
Liu, Tianju; Yu, Hongfeng; Ullenbruch, Matthew et al. (2014) The in vivo fibrotic role of FIZZ1 in pulmonary fibrosis. PLoS One 9:e88362
Arthur, Anna E; Peterson, Karen E; Shen, Jincheng et al. (2014) Diet and proinflammatory cytokine levels in head and neck squamous cell carcinoma. Cancer 120:2704-12
Zhang, Wenliang; Mottillo, Emilio P; Zhao, Jiawei et al. (2014) Adipocyte lipolysis-stimulated interleukin-6 production requires sphingosine kinase 1 activity. J Biol Chem 289:32178-85
Kim, Boklye; Srinivasan, Ashok; Sabb, Brian et al. (2014) Diffusion tensor imaging of the sural nerve in normal controls. Clin Imaging 38:648-54

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