- Clinical Core The Clinical Core of the Michigan Diabetes Research Center (MDRC) provides resources and expertise to enhance the effectiveness, efficiency, and multidisciplinary nature of clinical research performed by MDRC investigators. Specifically, the Clinical Core provides resources and expertise to support type 1 translational research that focuses on moving basic science discovery and preclinical development into people with diabetes in order to enhance human health and well-being. This bench-to-bedside process may involve testing new drugs, devices, or treatment programs for patients at risk for or with diabetes and its complications and comorbidities or with related metabolic and endocrine disorders. The MDRC Clinical Core provides MDRC clinical investigators: ? Well?equipped and accessible clinical research space for diabetes-related studies, ? Expertise and resources to facilitate the recruitment of diabetic subjects into clinical studies, ? A chemistry laboratory to provide expertise and state-of-the-art laboratory analytical services, and ? Biostatistical services to address experimental design, data management, and data analysis. Since its creation five years ago, the Clinical Core has adapted to the changing University of Michigan (UM) research environment and the evolving needs of MDRC investigators to provide ready access to well-equipped research space and to expand access to potential research subjects using tools made possible by the implementation of the new UM electronic medical record. In addition, the Clinical Core has rolled out new laboratory services with excellent quality control and low cost. It has also brought on new staff to assist with study design, data management, and data analysis. All of these services are designed to facilitate diabetes- related clinical research and collaboration. Discoveries made at a molecular or whole animal level can be tested in human subjects using the resources of the Clinical Core. Similarly, observations made using Clinical Core resources can be understood at a more detailed and mechanistic level using resources provided by MDRC biomedical research cores.

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Center Core Grants (P30)
Project #
2P30DK020572-41
Application #
9443254
Study Section
Special Emphasis Panel (ZDK1)
Project Start
Project End
Budget Start
2017-12-01
Budget End
2018-11-30
Support Year
41
Fiscal Year
2018
Total Cost
Indirect Cost
Name
University of Michigan Ann Arbor
Department
Type
DUNS #
073133571
City
Ann Arbor
State
MI
Country
United States
Zip Code
48109
Zhang, Hongyu; Nair, Viji; Saha, Jharna et al. (2017) Podocyte-specific JAK2 overexpression worsens diabetic kidney disease in mice. Kidney Int 92:909-921
Ward, Kristen M; Kraal, A Zarina; Flowers, Stephanie A et al. (2017) Cardiovascular Pharmacogenomics and Cognitive Function in Patients with Schizophrenia. Pharmacotherapy 37:1122-1130
Soofi, Abdul; Wolf, Katherine I; Emont, Margo P et al. (2017) The kielin/chordin-like protein (KCP) attenuates high-fat diet-induced obesity and metabolic syndrome in mice. J Biol Chem 292:9051-9062
Bian, Rachel R; Piatt, Gretchen A; Sen, Ananda et al. (2017) The Effect of Technology-Mediated Diabetes Prevention Interventions on Weight: A Meta-Analysis. J Med Internet Res 19:e76
Lager, Corey J; Esfandiari, Nazanene H; Subauste, Angela R et al. (2017) Roux-En-Y Gastric Bypass Vs. Sleeve Gastrectomy: Balancing the Risks of Surgery with the Benefits of Weight Loss. Obes Surg 27:154-161
Shen, Hong; Sheng, Liang; Xiong, Yi et al. (2017) Thymic NF-?B-inducing kinase regulates CD4+ T cell-elicited liver injury and fibrosis in mice. J Hepatol 67:100-109
Hinder, Lucy M; O'Brien, Phillipe D; Hayes, John M et al. (2017) Dietary reversal of neuropathy in a murine model of prediabetes and metabolic syndrome. Dis Model Mech 10:717-725
Cady, Gillian; Landeryou, Taylor; Garratt, Michael et al. (2017) Hypothalamic growth hormone receptor (GHR) controls hepatic glucose production in nutrient-sensing leptin receptor (LepRb) expressing neurons. Mol Metab 6:393-405
Welch, Whitney A; Alexander, Neil B; Swartz, Ann M et al. (2017) Individualized Estimation of Physical Activity in Older Adults with Type 2 Diabetes. Med Sci Sports Exerc 49:2185-2190
O'Brien, Phillipe D; Hinder, Lucy M; Parlee, Sebastian D et al. (2017) Dual CCR2/CCR5 antagonist treatment attenuates adipose inflammation, but not microvascular complications in ob/ob mice. Diabetes Obes Metab 19:1468-1472

Showing the most recent 10 out of 1325 publications