The mission of the Washington University School of Medicine (WUMS) Diabetes Research Center (DRC) is to support and enhance research in diabetes and related metabolic diseases through Biomedical Research Core services reflecting the evolving needs of diabetes investigators, a vibrant Pilot &Feasibility Program and a dynamic Enrichment Program. Now in Its 35th year of continuous NIDDK funding, this DRC is located at an outstanding research institution with a longstanding tradition of excellence in diabetes investigation. The WUMS DRC Research Base is organized in three Focus Groups: Metabolic Regulation, Complications, and Islet Biology &Immunology. Investigators from each of these groups participate in DRC programs that address two central, interacting scientific themes-a) Approaches Across the Translational Spectrum, and b) Prevention of Diabetes Complications. Evidence that the WUMS DRC continues to successfully pursue the mission outlined in this renewal application Includes a record of outstanding productivity reflected by publications and peer-reviewed funding in diabetes and related research. Our research strategy will build on these accomplishments by: 1. Creating an environment that supports important as well as innovative research In diabetes and related metabolic disorders; 2. Supporting cutting edge basic and clinical research related to etiology, pathogenesis, prevention and cure of diabetes; 3. Raising awareness and interest in fundamental and clinical diabetes research in addition to enhancing multldisciplinary approaches to diabetes and its complications;and 4. Translating new knowledge in diabetes to improved treatment of patients with diabetes.
Diabetes and related metabolic disorders of obesity, insulin resistance, and metabolic syndrome are complex, systemic diseases involving environmental arid genetic Influences. The infrastructure and support of the DRC, as well as the collaborative nature of the DRC, are designed to foster multldisciplinary approaches across the translational spectrum to achieve progress in understanding the pathophysiology of these disorders and to develop of new treatments, cures and preventive strategies.
|Muniappan, Latha; Javidan, Aida; Jiang, Weihua et al. (2017) Calpain Inhibition Attenuates Adipose Tissue Inflammation and Fibrosis in Diet-induced Obese Mice. Sci Rep 7:14398|
|Andrich, Kathrin; Hegenbart, Ute; Kimmich, Christoph et al. (2017) Aggregation of Full-length Immunoglobulin Light Chains from Systemic Light Chain Amyloidosis (AL) Patients Is Remodeled by Epigallocatechin-3-gallate. J Biol Chem 292:2328-2344|
|Lucey, Brendan P; Mawuenyega, Kwasi G; Patterson, Bruce W et al. (2017) Associations Between ?-Amyloid Kinetics and the ?-Amyloid Diurnal Pattern in the Central Nervous System. JAMA Neurol 74:207-215|
|Kim, Yeawon; Park, Sun-Ji; Chen, Ying Maggie (2017) Mesencephalic astrocyte-derived neurotrophic factor (MANF), a new player in endoplasmic reticulum diseases: structure, biology, and therapeutic roles. Transl Res 188:1-9|
|Mikhalkova, Deana; Holman, Sujata R; Jiang, Hui et al. (2017) Bariatric Surgery-Induced Cardiac and Lipidomic Changes in Obesity-Related Heart Failure with Preserved Ejection Fraction. Obesity (Silver Spring) :|
|Villareal, Dennis T; Aguirre, Lina; Gurney, A Burke et al. (2017) Aerobic or Resistance Exercise, or Both, in Dieting Obese Older Adults. N Engl J Med 376:1943-1955|
|Lin, Meei-Hua; Miner, Jeffrey H; Turk, John et al. (2017) Linear ion-trap MSn with high-resolution MS reveals structural diversity of 1-O-acylceramide family in mouse epidermis. J Lipid Res 58:772-782|
|Park, Thomas; Eyler, Amy A; Tabak, Rachel G et al. (2017) Opportunities for Promoting Physical Activity in Rural Communities by Understanding the Interests and Values of Community Members. J Environ Public Health 2017:8608432|
|Yamaguchi, Shintaro; Yoshino, Jun (2017) Adipose tissue NAD+ biology in obesity and insulin resistance: From mechanism to therapy. Bioessays 39:|
|Kim, Yeawon; Park, Sun-Ji; Manson, Scott R et al. (2017) Elevated urinary CRELD2 is associated with endoplasmic reticulum stress-mediated kidney disease. JCI Insight 2:|
Showing the most recent 10 out of 565 publications