The Hormone Assay and Analytical Services Core (HAASC) provides assistance to investigators in the measurement of hormones, amino acids ( concentration and specific activity), glucose enrichment, lipids, nucleotides, and markers of oxidative stress in biologic fluids and tissue samples. The core provides space, equipment and personnel that performs sample analysis and method development. Investigators pay a fee for service that covers the cost of regents, supplies, a percentage of personnel salary and pro-rated service contracts. Over the last grant cycle this core has dramatically evolved. With support from the institution the core has purchased equipment that will lower overall cost and decrease turnaround time for our standard high throughput assays and are continuing to offer cost effective new hormone assays to our investigators. The core has developed NMR assays to assess the enrichment of glucose (C2/C5), which is a marker of gluconeogenesis. We have expanded the scope of our services as the needs of VDRTC members change. The core assayed over 30,000 samples in the past year for 32 Vanderbilt investigators and 7 non-Vanderbilt investigators. Over the past grant cycle it provided data to support over 150 publications. The HAASC is jointly supported by the VDRTC and the NIDDK-funded Mouse Metabolic Phenotyping Center. This cooperative arrangement allows the core to offer a wide range of services in a non-overlapping, cost efficient manner. The core is part of the Vanderbilt Core Ordering &Reporting Enterprise Systemtm, which provides an efficient billing system and oversight and governance for the core. The Hormone Assay and Analytical Services Core, in operation for more than 30 years, continues to provide essential services that support the research of DRTC-affiliated investigators in the next funding cycle.

National Institute of Health (NIH)
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Center Core Grants (P30)
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Special Emphasis Panel (ZDK1-GRB-S)
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Vanderbilt University Medical Center
United States
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Reissaus, Christopher A; Piston, David W (2017) Reestablishment of Glucose Inhibition of Glucagon Secretion in Small Pseudoislets. Diabetes 66:960-969
Kobayashi, Hanako; Liu, Jiao; Urrutia, Andres A et al. (2017) Hypoxia-inducible factor prolyl-4-hydroxylation in FOXD1 lineage cells is essential for normal kidney development. Kidney Int 92:1370-1383
Spurlock 3rd, Charles F; Shaginurova, Guzel; Tossberg, John T et al. (2017) Profiles of Long Noncoding RNAs in Human Naive and Memory T Cells. J Immunol 199:547-558
Jao, Li-En; Akef, Abdalla; Wente, Susan R (2017) A role for Gle1, a regulator of DEAD-box RNA helicases, at centrosomes and basal bodies. Mol Biol Cell 28:120-127
Dickerson, Matthew T; Vierra, Nicholas C; Milian, Sarah C et al. (2017) Osteopontin activates the diabetes-associated potassium channel TALK-1 in pancreatic ?-cells. PLoS One 12:e0175069
Traver, Geri; Mont, Stacey; Gius, David et al. (2017) Loss of Nrf2 promotes alveolar type 2 cell loss in irradiated, fibrotic lung. Free Radic Biol Med 112:578-586
Lapierre, Lynne A; Manning, Elizabeth H; Mitchell, Kenya M et al. (2017) Interaction of phosphorylated Rab11-FIP2 with Eps15 regulates apical junction composition. Mol Biol Cell 28:1088-1100
Ritter, K Elaine; Wang, Zunyi; Vezina, Chad M et al. (2017) Serotonin Receptor 5-HT3A Affects Development of Bladder Innervation and Urinary Bladder Function. Front Neurosci 11:690
Corbett, Blythe A; Blain, Scott D; Ioannou, Sara et al. (2017) Changes in anxiety following a randomized control trial of a theatre-based intervention for youth with autism spectrum disorder. Autism 21:333-343
Stephenson, Jason R; Wang, Xiaohan; Perfitt, Tyler L et al. (2017) A Novel Human CAMK2A Mutation Disrupts Dendritic Morphology and Synaptic Transmission, and Causes ASD-Related Behaviors. J Neurosci 37:2216-2233

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