An Animal Models and Physiology Core has been a unit of the DRTC since 1991. It was initially established to assist investigators in the generation of genetically modified mice. The Core has continued to evolve during the past funding period and now includes Mouse Metabolic Phenotyping as a service. The Animal Model and Physiology Core provides to Center members via access to a wide array of resources, technology, equipment and services for the generation and study of genetically modified mice and other model organisms in diabetes-related research, consultation on experimental design and analysis, repositories (mouse and human ES cells, mouse models), technology development (large-scale analysis of pancreatic islets from mice to man) and opportunities for collaboration. Some services are widely used (e.g. generation of transgenic and knockout mice and metabolic phenotyping) whereas others less so (advice and training in human ES cells). Nonetheless, rather than discontinuing unique or very specialized but rarely used services, we still list them on the DRTC website since future needs of members cannot be predicted and the leadership believes strongly that including them allows members to consider all available technologies in planning their research. Drs. Manami Hara and Anita Chong will continue to serve as Director and Co-Director of this Core. They will also be assisted by Technical Directors for Transgenic/ES Cell Technology (Degenstein) and Mouse Metabolic Phenotyping (Ye). The Core will have an internal advisory panel comprised of investigators using model organisms for diabetes/metabolism-related research: mice (Bass, Bell and Nobrega), zebrafish (Prince), Drosophila (Kreitman) and C. elegans (Ruvinsky). This organization will ensure that Core services are at the forefront of model organism studies and responsive to the needs of DRTC members.

Public Health Relevance

The Animal Models Core provides services, advice and hands-on-training for the generation and use of model organisms including mice, Zebrafish, Drosophiia and C elegans in the study of diabetes and metabolism. It facilitates the generation of useful models for studying pancreatic beta cells and the biology and physiology of genes implicated in the development of diabetes.

National Institute of Health (NIH)
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Center Core Grants (P30)
Project #
Application #
Study Section
Special Emphasis Panel (ZDK1-GRB-S)
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
University of Chicago
United States
Zip Code
Martyn-Nemeth, Pamela; Quinn, Laurie; Menon, Usha et al. (2017) Dietary Profiles of First-Generation South Asian Indian Adolescents in the United States. J Immigr Minor Health 19:309-317
Graff, Mariaelisa; Emery, Leslie S; Justice, Anne E et al. (2017) Genetic architecture of lipid traits in the Hispanic community health study/study of Latinos. Lipids Health Dis 16:200
Greeley, Siri Atma W; Zielinski, Mark C; Poudel, Ananta et al. (2017) Preservation of Reduced Numbers of Insulin-Positive Cells in Sulfonylurea-Unresponsive KCNJ11-Related Diabetes. J Clin Endocrinol Metab 102:1-5
Letourneau, Lisa R; Carmody, David; Wroblewski, Kristen et al. (2017) Diabetes Presentation in Infancy: High Risk of Diabetic Ketoacidosis. Diabetes Care 40:e147-e148
Lanning, Monica S; Carmody, David; Szczerbi?ski, ?ukasz et al. (2017) Hypoglycemia in sulfonylurea-treated KCNJ11-neonatal diabetes: Mild-moderate symptomatic episodes occur infrequently but none involving unconsciousness or seizures. Pediatr Diabetes :
Coats, Brittney R; Schoenfelt, Kelly Q; Barbosa-Lorenzi, Valéria C et al. (2017) Metabolically Activated Adipose Tissue Macrophages Perform Detrimental and Beneficial Functions during Diet-Induced Obesity. Cell Rep 20:3149-3161
Hon, Jason; Hwang, Michelle S; Charnetzki, Meara A et al. (2017) Kinetic characterization of the inhibition of protein tyrosine phosphatase-1B by Vanadyl (VO2+) chelates. J Biol Inorg Chem 22:1267-1279
Kropp, Erin M; Broniowska, Katarzyna A; Waas, Matthew et al. (2017) Cardiomyocyte Differentiation Promotes Cell Survival During Nicotinamide Phosphoribosyltransferase Inhibition Through Increased Maintenance of Cellular Energy Stores. Stem Cells Transl Med 6:1191-1201
Palygin, Oleg; Evans, Louise C; Cowley Jr, Allen W et al. (2017) Acute In Vivo Analysis of ATP Release in Rat Kidneys in Response to Changes of Renal Perfusion Pressure. J Am Heart Assoc 6:
Manning, Alisa (see original citation for additional authors) (2017) A Low-Frequency Inactivating AKT2 Variant Enriched in the Finnish Population Is Associated With Fasting Insulin Levels and Type 2 Diabetes Risk. Diabetes 66:2019-2032

Showing the most recent 10 out of 255 publications