Abstract

The Proteomics Core aims to provide HDDC investigators with access to state of the arttechnologies in mass spectrometry, microscale capillary high performance liquid chromatography, andrelated proteomics technologies required for advanced studies in cell and molecular biology of theintestinal epjthelium. Dr. Hanno Steen PhD, (Assistant Professor of Pathology, HMS) directs the Coreand is responsible for all core activities. The Core is the most advanced proteomics unit on the HMScampus.The significance of the research supported by the Proteomics Core D is emphasized by therapid advances in technology for the unbiased and efficient identification of proteins in biologicalsamples that has allowed new approaches to studies on the intestinal mucosa.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Center Core Grants (P30)
Project #
2P30DK034854-21A1
Application #
7001989
Study Section
Special Emphasis Panel (ZDK1-GRB-8 (M1))
Project Start
2005-12-01
Project End
2010-11-30
Budget Start
2005-12-01
Budget End
2006-11-30
Support Year
21
Fiscal Year
2006
Total Cost
$50,676
Indirect Cost

  Institution

Name
Children's Hospital Boston
Department
Type
DUNS #
076593722
City
Boston
State
MA
Country
United States
Zip Code
02115

  Publications

Nudel, K; Zhao, X; Basu, S et al. (2018) Genomics of Corynebacterium striatum, an emerging multidrug-resistant pathogen of immunocompromised patients. Clin Microbiol Infect 24:1016.e7-1016.e13
Biswas, Amlan; Shouval, Dror S; Griffith, Alexandra et al. (2018) WASP-mediated regulation of anti-inflammatory macrophages is IL-10 dependent and is critical for intestinal homeostasis. Nat Commun 9:1779
Han, Lichy; Maciejewski, Mateusz; Brockel, Christoph et al. (2018) A probabilistic pathway score (PROPS) for classification with applications to inflammatory bowel disease. Bioinformatics 34:985-993
Fishman, Laurie N; Kearney, Jennifer; DeGroote, Maya et al. (2018) Creation of Experience-based Celiac Benchmarks: The First Step in Pretransition Self-management Assessment. J Pediatr Gastroenterol Nutr 67:e6-e10
Kamareddine, Layla; Robins, William P; Berkey, Cristin D et al. (2018) The Drosophila Immune Deficiency Pathway Modulates Enteroendocrine Function and Host Metabolism. Cell Metab 28:449-462.e5
Iyer, Shankar S; Gensollen, Thomas; Gandhi, Amit et al. (2018) Dietary and Microbial Oxazoles Induce Intestinal Inflammation by Modulating Aryl Hydrocarbon Receptor Responses. Cell 173:1123-1134.e11
McSweeney, Maireade E; Kerr, Jessica; Amirault, Janine et al. (2018) Preoperative Evaluation Is Not Predictive of Transpyloric Feeding Conversion in Gastrostomy-dependent Pediatric Patients. J Pediatr Gastroenterol Nutr 66:887-892
Thiagarajah, Jay R; Kamin, Daniel S; Acra, Sari et al. (2018) Advances in Evaluation of Chronic Diarrhea in Infants. Gastroenterology 154:2045-2059.e6
Masuyer, Geoffrey; Zhang, Sicai; Barkho, Sulyman et al. (2018) Structural characterisation of the catalytic domain of botulinum neurotoxin X - high activity and unique substrate specificity. Sci Rep 8:4518
Xenakis, Jason J; Howard, Emily D; Smith, Kalmia M et al. (2018) Resident intestinal eosinophils constitutively express antigen presentation markers and include two phenotypically distinct subsets of eosinophils. Immunology 154:298-308

Showing the most recent 10 out of 869 publications