The Harvard Digestive Diseases Center (HDDC) is a consortium of 63 independent investigators and 39 Associate Members with over $32 M annual research funding directly related to digestive diseases (34%NIDDK). The HDDC is focused on the cell biology and function of epithelial cells of the alimentary tract and the complex interactions of epithelia with the microbial flora and subepithelial cells of the lamina propria that result in mucosal immunity, allergy, innate host defense, digestion and absorption, the development of gastrointestinal neoplasia, and the many other functions of the Gl tract. Center Directors Drs. Wayne Lencer (PI) and Richard Blumberg (Co-PI) are scientific colleagues, Division Chiefs of Pediatric and Adult Gl at two major Harvard teaching hospitals, and leaders of NIH-funded training programs in Gastroenterology. The enrichment program includes an annual scientific symposium, a biannual regional conference """"""""Frontiers in Mucosal Immunology"""""""", and two seminar series. The HDDC pilot-feasibility grant program is highly subscribed and competitive;the majority of previous awardees are now independently funded and still in digestive diseases-related research. A biostatistics resource supports translational/clinical research of HDDC members. The Imaging Core B provides advanced high-resolution light microscopy of fixed and live cells and tissues, and electron microscopy including EM tomography. The Epithelial Cell Biology Core C provides epithelial cell culture and transfection, microfluorimetry, electrophysiology, multi-color FACS, and multiplexed direct quantification of individual mRNAs. The Molecular and Cellular Biochemistry Core D provides protein and lipid purification and analysis and proteomic technologies. A new Gnotobiotics and Microbiology Core E provides access to germfree mouse isolators, stocks of germfree mice, microbiological assays, and a library of commensal and pathogen strains for use in the study of the gastrointestinal commensal flora and BL1 and BL2 pathogens. Our overarching mission is to foster and expand basic and translational science in digestive diseases by: 'connecting people, 'creating opportunity, and 'extending resources.
The Center facilitates multidisciplinary research in gastrointestinal diseases by providing technical resources, core services, scientific expertise, and an important meeting point to foster close scientific and intellectual relationships among independent investigators in Harvard-affiliated hospitals, the Harvard Medical School and adjacent research institutions in Boston's Longwood Medical Area. We also aim to recruit new and established investigators to the field.
|Shaw, Kelly A; Cutler, David J; Okou, David et al. (2018) Genetic variants and pathways implicated in a pediatric inflammatory bowel disease cohort. Genes Immun :|
|Lyons, Jesse; Ghazi, Phaedra C; Starchenko, Alina et al. (2018) The colonic epithelium plays an active role in promoting colitis by shaping the tissue cytokine profile. PLoS Biol 16:e2002417|
|Kotlarz, Daniel; Marquardt, Benjamin; Barøy, Tuva et al. (2018) Human TGF-?1 deficiency causes severe inflammatory bowel disease and encephalopathy. Nat Genet 50:344-348|
|Vardi, Iddo; Barel, Ortal; Sperber, Michal et al. (2018) Genetic and Structural Analysis of a SKIV2L Mutation Causing Tricho-hepato-enteric Syndrome. Dig Dis Sci 63:1192-1199|
|Garcia-Castillo, Maria Daniela; Chinnapen, Daniel J-F; Te Welscher, Yvonne M et al. (2018) Mucosal absorption of therapeutic peptides by harnessing the endogenous sorting of glycosphingolipids. Elife 7:|
|Basu, Sankha S; Delaney, Mary L; Li, Ning et al. (2018) Acetobacter indonesiensis Pneumonia after Lung Transplantation. Emerg Infect Dis 24:598-599|
|Yien, Yvette Y; Shi, Jiahai; Chen, Caiyong et al. (2018) FAM210B is an erythropoietin target and regulates erythroid heme synthesis by controlling mitochondrial iron import and ferrochelatase activity. J Biol Chem 293:19797-19811|
|Garber, John J; Mallick, Emily M; Scanlon, Karen M et al. (2018) Attaching-and-Effacing Pathogens Exploit Junction Regulatory Activities of N-WASP and SNX9 to Disrupt the Intestinal Barrier. Cell Mol Gastroenterol Hepatol 5:273-288|
|Maglic, Dejan; Schlegelmilch, Karin; Dost, Antonella Fm et al. (2018) YAP-TEAD signaling promotes basal cell carcinoma development via a c-JUN/AP1 axis. EMBO J 37:|
|Bader, Razan M; Jonas, Maureen M; Mitchell, Paul D et al. (2018) Controlled attenuation parameter: A measure of hepatic steatosis in patients with cystic fibrosis. J Cyst Fibros :|
Showing the most recent 10 out of 869 publications