The Harvard Digestive Diseases Center (HDDC) is a consortium of 63 independent investigators and 39 Associate Members with over $32 M annual research funding directly related to digestive diseases (34%NIDDK). The HDDC is focused on the cell biology and function of epithelial cells of the alimentary tract and the complex interactions of epithelia with the microbial flora and subepithelial cells of the lamina propria that result in mucosal immunity, allergy, innate host defense, digestion and absorption, the development of gastrointestinal neoplasia, and the many other functions of the Gl tract. Center Directors Drs. Wayne Lencer (PI) and Richard Blumberg (Co-PI) are scientific colleagues, Division Chiefs of Pediatric and Adult Gl at two major Harvard teaching hospitals, and leaders of NIH-funded training programs in Gastroenterology. The enrichment program includes an annual scientific symposium, a biannual regional conference """"""""Frontiers in Mucosal Immunology"""""""", and two seminar series. The HDDC pilot-feasibility grant program is highly subscribed and competitive;the majority of previous awardees are now independently funded and still in digestive diseases-related research. A biostatistics resource supports translational/clinical research of HDDC members. The Imaging Core B provides advanced high-resolution light microscopy of fixed and live cells and tissues, and electron microscopy including EM tomography. The Epithelial Cell Biology Core C provides epithelial cell culture and transfection, microfluorimetry, electrophysiology, multi-color FACS, and multiplexed direct quantification of individual mRNAs. The Molecular and Cellular Biochemistry Core D provides protein and lipid purification and analysis and proteomic technologies. A new Gnotobiotics and Microbiology Core E provides access to germfree mouse isolators, stocks of germfree mice, microbiological assays, and a library of commensal and pathogen strains for use in the study of the gastrointestinal commensal flora and BL1 and BL2 pathogens. Our overarching mission is to foster and expand basic and translational science in digestive diseases by: 'connecting people, 'creating opportunity, and 'extending resources.

Public Health Relevance

The Center facilitates multidisciplinary research in gastrointestinal diseases by providing technical resources, core services, scientific expertise, and an important meeting point to foster close scientific and intellectual relationships among independent investigators in Harvard-affiliated hospitals, the Harvard Medical School and adjacent research institutions in Boston's Longwood Medical Area. We also aim to recruit new and established investigators to the field.

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Center Core Grants (P30)
Project #
5P30DK034854-29
Application #
8578077
Study Section
Special Emphasis Panel (ZDK1-GRB-8 (M1))
Program Officer
Podskalny, Judith M,
Project Start
1997-09-01
Project End
2015-11-30
Budget Start
2013-12-01
Budget End
2014-11-30
Support Year
29
Fiscal Year
2014
Total Cost
$1,052,028
Indirect Cost
$270,127
Name
Children's Hospital Boston
Department
Type
DUNS #
076593722
City
Boston
State
MA
Country
United States
Zip Code
02115
Schulman, Allison R; Popov, Violeta; Thompson, Christopher C (2017) Randomized sham-controlled trials in endoscopy: a systematic review and meta-analysis of adverse events. Gastrointest Endosc 86:972-985.e3
Tschurtschenthaler, Markus; Adolph, Timon E; Ashcroft, Jonathan W et al. (2017) Defective ATG16L1-mediated removal of IRE1? drives Crohn's disease-like ileitis. J Exp Med 214:401-422
Hagen, Susan J (2017) Non-canonical functions of claudin proteins: Beyond the regulation of cell-cell adhesions. Tissue Barriers 5:e1327839
Tan, Yunhao; Kagan, Jonathan C (2017) Microbe-inducible trafficking pathways that control Toll-like receptor signaling. Traffic 18:6-17
Lexmond, W S; Goettel, J A; Sallis, B F et al. (2017) Spontaneous food allergy in Was-/- mice occurs independent of Fc?RI-mediated mast cell activation. Allergy 72:1916-1924
Yan, Kelley S; Gevaert, Olivier; Zheng, Grace X Y et al. (2017) Intestinal Enteroendocrine Lineage Cells Possess Homeostatic and Injury-Inducible Stem Cell Activity. Cell Stem Cell 21:78-90.e6
Lai, N Y; Mills, K; Chiu, I M (2017) Sensory neuron regulation of gastrointestinal inflammation and bacterial host defence. J Intern Med 282:5-23
Kamenju, Pili; Liu, Enju; Hertzmark, Ellen et al. (2017) Complementary Feeding and Diarrhea and Respiratory Infection Among HIV-Exposed Tanzanian Infants. J Acquir Immune Defic Syndr 74:265-272
Thiagarajah, Jay R; Chang, Jeffrey; Goettel, Jeremy A et al. (2017) Aquaporin-3 mediates hydrogen peroxide-dependent responses to environmental stress in colonic epithelia. Proc Natl Acad Sci U S A 114:568-573
Li, Jian; Shouval, Dror S; Doty, Andria L et al. (2017) Increased Mucosal IL-22 Production of an IL-10RA Mutation Patient Following Anakinra Treatment Suggests Further Mechanism for Mucosal Healing. J Clin Immunol 37:104-107

Showing the most recent 10 out of 769 publications