The Gnotobiotics, Microbiology and Metagenomics Core (Core D), aims to identify the causal relationships between our colonizing microbiota and host health and disease, both in human clinical trials and in animal models. Core D supports more than 50 groups interested in evaluating mechanisms by which the host's microbiota affects health and disease, with particular focus to define functional effects of microbial communities in vivo. Our resources include an Intake Unit to handle logistics for sample and data collection, a Molecular Unit for sequence-based analyses, Microbiology Unit to analyze primary samples and manipulate isolates for functional studies, a Gnotobiotic (germfree) mouse facility for in vivo studies in animal models, and Computational Unit which includes bioinformatics and computational support, including access to computational clusters and personnel for assisting in experimental design and analysis of complex metagenomic datasets. As a core we provide support to nearly all academic centers in the greater Boston area.

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Center Core Grants (P30)
Project #
2P30DK034854-31
Application #
8971193
Study Section
Special Emphasis Panel ()
Project Start
Project End
Budget Start
2015-12-01
Budget End
2016-11-30
Support Year
31
Fiscal Year
2016
Total Cost
$344,143
Indirect Cost
$38,500
Name
Children's Hospital Boston
Department
Type
DUNS #
076593722
City
Boston
State
MA
Country
United States
Zip Code
02115
Gornati, Laura; Zanoni, Ivan; Granucci, Francesca (2018) Dendritic Cells in the Cross Hair for the Generation of Tailored Vaccines. Front Immunol 9:1484
Blumberg, Richard S; Lillicrap, David; IgG Fc Immune Tolerance Group (2018) Tolerogenic properties of the Fc portion of IgG and its relevance to the treatment and management of hemophilia Blood 131:2205-2214
Yao, Lina; Seaton, Sarah Craven; Ndousse-Fetter, Sula et al. (2018) A selective gut bacterial bile salt hydrolase alters host metabolism. Elife 7:
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Lyons, Jesse; Ghazi, Phaedra C; Starchenko, Alina et al. (2018) The colonic epithelium plays an active role in promoting colitis by shaping the tissue cytokine profile. PLoS Biol 16:e2002417

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