Members of the Center for Gastrointestinal Biology and Disease (CGIBD) are basic and clinical scientists from diverse disciplines dedicated to advancing our understanding of the biology, physiology and epidemiology of digestive and liver diseases. The overarching hypothesis that integrates the scientific activities of CGIBD members is that most digestive and hepatic diseases are the result of complex interactions between host genetic susceptibility and environmental stimuli. The theme that links the research of center members is host-environment interactions in gastrointestinal and liver disease. The goal of the Center is to promote and enhance multidisciplinary and translational digestive disease research. The Center achieves this goal through: i) core facilities that provide training, technical assistance, laboratory animals, biostatistical and data management support, assays, and histology; 2) a pilot/ feasibility program that offers startup funds to junior investigators or to established investigators v^^ho wish to pursue a new research direction; 3) a scientific enrichment program consisting of seminars, symposia and workshops to improve the intellectual climate for digestive disease research and to promote cooperation, collaboration and communication among involved personnel; 4) a professional development and training program that fosters the careers of junior faculty. The research base includes 38 full members who have annual direct research support of $24.6 million. The broad areas of research performed by members include: microbiota, inflammation, liver disease, stem cells, gastrointestinal cancer and clinical research. To support the research of full members, the center proposes an Administrative Core to organize the activities of the Center and the following scientific cores: 1) Biostatistics and Bioinformatics; 2) Advanced Analytics; 3) Histology and Imaging; 4) Gnotobiotic Animal; 5) Microbiome; 6) Large Animal Models. These cores have evolved to support the scientific directions of center members and to provide new investigative opportunities. The cores improve efficiency, lower cost, and provide services that would not otherwise be available to investigators. Through all of its activities, the Center improves communication, promotes collaboration, develops careers, and generally enriches the environment for digestive disease research.
Gastrointestinal diseases and their complications have a significant health and economic impact. Research by members of this center has led to fundamental breakthroughs in our understanding of mechanisms responsible for inflammatory bowel diseases, liver disease, intestinal stem cells, and gastrointestinal cancer.
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|Jones, Roshonda B; Fodor, Anthony A; Peery, Anne F et al. (2018) An Aberrant Microbiota is not Strongly Associated with Incidental Colonic Diverticulosis. Sci Rep 8:4951|
|Busch, Evan L; Galanko, Joseph A; Sandler, Robert S et al. (2018) Lifestyle Factors, Colorectal Tumor Methylation, and Survival Among African Americans and European Americans. Sci Rep 8:9470|
|Eluri, Swathi; Cross, Raymond K; Martin, Christopher et al. (2018) Inflammatory Bowel Diseases Can Adversely Impact Domains of Sexual Function Such as Satisfaction with Sex Life. Dig Dis Sci 63:1572-1582|
|Dellon, Evan S; Selitsky, Sara R; Genta, Robert M et al. (2018) Gene expression-phenotype associations in adults with eosinophilic esophagitis. Dig Liver Dis 50:804-811|
|Rogala, Allison R; Schoenborn, Alexi A; Fee, Brian E et al. (2018) Environmental factors regulate Paneth cell phenotype and host susceptibility to intestinal inflammation in Irgm1-deficient mice. Dis Model Mech 11:|
|Li, Feng; Kakoki, Masao; Smid, Marcela et al. (2018) Causative Effects of Genetically Determined High Maternal/Fetal Endothelin-1 on Preeclampsia-Like Conditions in Mice. Hypertension 71:894-903|
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