Abstract

There presently are 67 Affiliate Investigators (Als) of the NORC (Table 1) representing a diversity of divisions, departments, and schools throughout the University of Washington (UW) system (see Table 2). Although most of the investigators are in clinical departments, the UW is unique in that many of its basic scientists actually have their primary appointments in clinical departments. There has been a longstanding interest in several aspects of nutrition and obesity at the UW. However, over the past several years, Als have tended to focus their research in the following major areas: 1. Body Weight Regulation and Obesity 2. Adipose Tissue Biology and Inflammation 3. Lipids and Atherosclerosis 4. Diabetes

Public Health Relevance

Obesity and associated metabolic disorders have emerged as leading health problems in the US and other westernized countries. Compounding this problem is a lack of effective nonsurgical treatments for obesity, which reflects deficiencies in our understanding of underlying causes. The NORC offers valuable resources to a large group of researchers at UW investigating nutrition, obesity and associated disorders.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Center Core Grants (P30)
Project #
5P30DK035816-29
Application #
8854067
Study Section
Special Emphasis Panel (ZDK1-GRB-2 (M3))
Program Officer
Evans, Mary
Project Start
1996-12-01
Project End
2017-06-30
Budget Start
2015-07-01
Budget End
2016-06-30
Support Year
29
Fiscal Year
2015
Total Cost
$1,255,315
Indirect Cost
$518,399

  Institution

Name
University of Washington
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
605799469
City
Seattle
State
WA
Country
United States
Zip Code
98195

  Publications

Berkseth, Kathryn E; Rubinow, Katya B; Melhorn, Susan J et al. (2018) Hypothalamic Gliosis by MRI and Visceral Fat Mass Negatively Correlate with Plasma Testosterone Concentrations in Healthy Men. Obesity (Silver Spring) 26:1898-1904
Melhorn, Susan J; Askren, Mary K; Chung, Wendy K et al. (2018) FTO genotype impacts food intake and corticolimbic activation. Am J Clin Nutr 107:145-154
Ginos, Bigina N R; Navarro, Sandi L; Schwarz, Yvonne et al. (2018) Circulating bile acids in healthy adults respond differently to a dietary pattern characterized by whole grains, legumes and fruits and vegetables compared to a diet high in refined grains and added sugars: A randomized, controlled, crossover feeding stud Metabolism 83:197-204
Shao, Dan; Villet, Outi; Zhang, Zhen et al. (2018) Glucose promotes cell growth by suppressing branched-chain amino acid degradation. Nat Commun 9:2935
Rubinow, Katya B; Houston, Barbara; Wang, Shari et al. (2018) Androgen receptor deficiency in monocytes/macrophages does not alter adiposity or glucose homeostasis in male mice. Asian J Androl 20:276-283
den Hartigh, Laura J; Gao, Zhan; Goodspeed, Leela et al. (2018) Obese Mice Losing Weight Due to trans-10,cis-12 Conjugated Linoleic Acid Supplementation or Food Restriction Harbor Distinct Gut Microbiota. J Nutr 148:562-572
Selamet, Umut; Katz, Ronit; Ginsberg, Charles et al. (2018) Serum Calcitriol Concentrations and Kidney Function Decline, Heart Failure, and Mortality in Elderly Community-Living Adults: The Health, Aging, and Body Composition Study. Am J Kidney Dis 72:419-428
Wright, Davene R; Christakis, Dimitri A; Lozano, Paula et al. (2018) Healthy, Wealthy, and Wise? Exploring Parent Comparative Optimism About Future Child Outcomes. MDM Policy Pract 3:2381468318774776
Meek, Thomas H; Matsen, Miles E; Faber, Chelsea L et al. (2018) In Uncontrolled Diabetes, Hyperglucagonemia and Ketosis Result From Deficient Leptin Action in the Parabrachial Nucleus. Endocrinology 159:1585-1594
Du, Dan; Gu, Haiwei; Djukovic, Danijel et al. (2018) Multiplatform Metabolomics Investigation of Antiadipogenic Effects on 3T3-L1 Adipocytes by a Potent Diarylheptanoid. J Proteome Res 17:2092-2101

Showing the most recent 10 out of 601 publications