During the past 20 years, the DERC, with its Core Laboratories, Enrichment Program and support for Pilot and Feasibility (P&F) studies, has played a major role in fostering expansion in the scope and intensity of research at the Joslin Diabetes Center and Harvard Medical School. The DERC has provided critical infrastructure for both basic and clinical research. It is not surprising, therefore, that over this period the research productivity of Joslin has expanded enormously. The Joslin DERC has evolved considerably over the past grant period. The Scientific Base has moved into new cutting-edge research areas and maintained the synergistic relationship between basic and translational work, which has already led to a new clinical treatment. The DERC Core Laboratories have been restructured. The Molecular Cluster containing the Genetics, Genomics and Proteomics Cores has added a new Bioinformatics Core, which will coordinate the challenge of handling massive amounts of data with the most up-to-date informatics tools and expertise. The Flow Cytometry Core has increased the range of its services with new equipment including a largeparticle sorter, which opens new research avenues. The Advanced Microscopy Core now can offer service on a Laser Capture Microdissection Microscope. The Special Assay Core has added many new assays and is able to handle an ever-increasing volume of samples. The Animal Physiology Core provides critical physiological measurements for the many mouse models created at Joslin. The management of the DERC is now much more efficient thanks to Website Services, which facilitates ordering, tracking of service, and chargeback mechanisms for the Cores;and handles the P&F proposal process and the Enrichment Program. The P&F study program continues to be very successful in supporting young investigators and innovative research at Joslin and other Harvard research institutions. The Enrichment Program continues to enhance the research environment for students, post-doctoral fellows and investigators by supporting a valuable array of academic exercises and visiting speakers.

National Institute of Health (NIH)
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Center Core Grants (P30)
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Study Section
Special Emphasis Panel (ZDK1-GRB-N (J1))
Program Officer
Hyde, James F
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Joslin Diabetes Center
United States
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Mezza, Teresa; Sorice, Gian P; Conte, Caterina et al. (2016) β-Cell Glucose Sensitivity Is Linked to Insulin/Glucagon Bihormonal Cells in Nondiabetic Humans. J Clin Endocrinol Metab 101:470-5
Shirakawa, J; Kulkarni, R N (2016) Novel factors modulating human β-cell proliferation. Diabetes Obes Metab 18 Suppl 1:71-7
Bonner-Weir, Susan; Aguayo-Mazzucato, Cristina (2016) Physiology: Pancreatic β-cell heterogeneity revisited. Nature 535:365-6
Hettmer, Simone; Lin, Michael M; Tchessalova, Daria et al. (2016) Hedgehog-driven myogenic tumors recapitulate skeletal muscle cellular heterogeneity. Exp Cell Res 340:43-52
Kokoye, Yasin; Ivanov, Ivan; Cheng, Qiufang et al. (2016) A comparison of the effects of factor XII deficiency and prekallikrein deficiency on thrombus formation. Thromb Res 140:118-24
Vegas, Arturo J; Veiseh, Omid; Doloff, Joshua C et al. (2016) Combinatorial hydrogel library enables identification of materials that mitigate the foreign body response in primates. Nat Biotechnol 34:345-52
Khamaisi, Mogher; Katagiri, Sayaka; Keenan, Hillary et al. (2016) PKCδ inhibition normalizes the wound-healing capacity of diabetic human fibroblasts. J Clin Invest 126:837-53
Garvey, Katharine C; Telo, Gabriela H; Needleman, Joseph S et al. (2016) Health Care Transition in Young Adults With Type 1 Diabetes: Perspectives of Adult Endocrinologists in the U.S. Diabetes Care 39:190-7
Bonner-Weir, Susan; Aguayo-Mazzucato, Cristina; Weir, Gordon C (2016) Dynamic development of the pancreas from birth to adulthood. Ups J Med Sci 121:155-8
Ogawa, Takahiro; Kodera, Yukihiro; Hirata, Dai et al. (2016) Natural thioallyl compounds increase oxidative stress resistance and lifespan in Caenorhabditis elegans by modulating SKN-1/Nrf. Sci Rep 6:21611

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