Mass spectrometry techniques, particularly those requiring the measurement of stable (non-radioactive) nuclide enrichment in biological samples, have become established tools in the study of human nutrition and metabolism. Such methods, though technically demanding, are uniquely suited to quantitative In vivo studies under various pathophysiologic states. The Core's initiative to combine whole body tracer approaches with tissue specific mobile PET imaging is a novel means to evaluate metabolic alterations and has significant applicability to obese and non-obese subjects. Likewise, the addition of a metabolomics and lipidomics component to the Core will further enhance the scope of nutritional and metabolic studies available to the NORC-H investigators. This Core, its Director and Co-Directors, as well as its senior technician will provide: 1. Assistance in the design of successful nutritional stable isotope, and PET experiments including tracer selection, isotope preparation for infusion, and consultation regarding institutional review board approval. 2. A metabolomics platform capable of biomarker and metabolite discovery, biomarker and metabolite identification and metabolite quantitation. 3. Efficient and equitable access to Core analytic instruments, accurate analyses of samples, and quality control. 4. Assistance in the development of new methods for analyses of compounds in biologic samples including blood, urine, tissues and expired air. 5. An opportunity for new investigators to learn about the application of stable isotope-tracer techniques, PET and metabolomics in metabolic/nutritional research.

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Center Core Grants (P30)
Project #
5P30DK040561-18
Application #
8715765
Study Section
Special Emphasis Panel (ZDK1)
Project Start
Project End
Budget Start
2014-08-01
Budget End
2015-07-31
Support Year
18
Fiscal Year
2014
Total Cost
Indirect Cost
Name
Massachusetts General Hospital
Department
Type
DUNS #
City
Boston
State
MA
Country
United States
Zip Code
02199
Carmody, Jill S; Muñoz, Rodrigo; Yin, Huali et al. (2016) Peripheral, but not central, GLP-1 receptor signaling is required for improvement in glucose tolerance after Roux-en-Y gastric bypass in mice. Am J Physiol Endocrinol Metab 310:E855-61
Sztam, Kevin A; Liu, Enju; Manji, Karim P et al. (2016) Maternal Antiretroviral Therapy Is Associated with Lower Risk of Diarrhea in Early Childhood. J Pediatr 175:54-60
Nou, Eric; Lo, Janet; Grinspoon, Steven K (2016) Inflammation, immune activation, and cardiovascular disease in HIV. AIDS 30:1495-509
Dichtel, Laura E; Eajazi, Alireza; Miller, Karen K et al. (2016) Short- and Long-Term Reproducibility of Intrahepatic Lipid Quantification by 1H-MR Spectroscopy and CT in Obesity. J Comput Assist Tomogr 40:678-82
Fullerton, Brenna S; Sparks, Eric A; Hall, Amber M et al. (2016) Enteral autonomy, cirrhosis, and long term transplant-free survival in pediatric intestinal failure patients. J Pediatr Surg 51:96-100
Heymsfield, S B; Peterson, C M; Thomas, D M et al. (2016) Why are there race/ethnic differences in adult body mass index-adiposity relationships? A quantitative critical review. Obes Rev 17:262-75
Sparks, Eric A; Khan, Faraz A; Fisher, Jeremy G et al. (2016) Necrotizing enterocolitis is associated with earlier achievement of enteral autonomy in children with short bowel syndrome. J Pediatr Surg 51:92-5
Fazeli, Pouneh K; Teoh, Jonathan G; Lam, Eleanor L et al. (2016) Effect of growth hormone treatment on diastolic function in patients who have developed growth hormone deficiency after definitive treatment of acromegaly. Growth Horm IGF Res 26:17-23
Peterson, Courtney M; Thomas, Diana M; Blackburn, George L et al. (2016) Universal equation for estimating ideal body weight and body weight at any BMI. Am J Clin Nutr 103:1197-203
Schulz, Tim J; Graja, Antonia; Huang, Tian Lian et al. (2016) Loss of BMP receptor type 1A in murine adipose tissue attenuates age-related onset of insulin resistance. Diabetologia 59:1769-77

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