Introduction: The overall goal(s) of the Digestive Diseases Research Core Center at the University of Chicago, facilitated by the Administrative Core, will be to continue to foster and expand gastrointestinal-related research by its clinical and basic science faculty, particularly in the areas of IBD, and the immunology, inflammation, and microbiology of the Gl tract. This will be accomplished by offering special expertise, analytical services, Pilot &Feasibility and Enrichment Programs and support for young investigators seeking preliminary data for new research initiatives related to digestive diseases, as well as in aiding established investigators with their digestive diseases-related research. It is strongly anticipated that the Administrative Core will continue to play a central role in expanding IBDrelated research at the University, as well as locally and at a national level.

National Institute of Health (NIH)
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Center Core Grants (P30)
Project #
Application #
Study Section
Special Emphasis Panel (ZDK1-GRB-8)
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
University of Chicago
United States
Zip Code
An, Gary; Kulkarni, Swati (2015) An agent-based modeling framework linking inflammation and cancer using evolutionary principles: description of a generative hierarchy for the hallmarks of cancer and developing a bridge between mechanism and epidemiological data. Math Biosci 260:16-24
Wu, Shaoping; Zhang, Yong-Guo; Lu, Rong et al. (2015) Intestinal epithelial vitamin D receptor deletion leads to defective autophagy in colitis. Gut 64:1082-94
Jin, H R; Liao, Y; Li, X et al. (2014) Anticancer compound Oplopantriol A kills cancer cells through inducing ER stress and BH3 proteins Bim and Noxa. Cell Death Dis 5:e1190
Lu, R; Wu, S; Zhang, Y-G et al. (2014) Enteric bacterial protein AvrA promotes colonic tumorigenesis and activates colonic beta-catenin signaling pathway. Oncogenesis 3:e105
McDonald, Benjamin D; Bunker, Jeffrey J; Ishizuka, Isabel E et al. (2014) Elevated T cell receptor signaling identifies a thymic precursor to the TCR??(+)CD4(-)CD8?(-) intraepithelial lymphocyte lineage. Immunity 41:219-29
Li, Yan Chun (2014) Discovery of vitamin D hormone as a negative regulator of the renin-angiotensin system. Clin Chem 60:561-2
Chuang, Alice Y; Chuang, Jim C; Zhai, Zili et al. (2014) NOD2 expression is regulated by microRNAs in colonic epithelial HCT116 cells. Inflamm Bowel Dis 20:126-35
Leone, Vanessa A; Cham, Candace M; Chang, Eugene B (2014) Diet, gut microbes, and genetics in immune function: can we leverage our current knowledge to achieve better outcomes in inflammatory bowel diseases? Curr Opin Immunol 31:16-23
Evans, Christian C; LePard, Kathy J; Kwak, Jeff W et al. (2014) Exercise prevents weight gain and alters the gut microbiota in a mouse model of high fat diet-induced obesity. PLoS One 9:e92193
Jabri, Bana; Chen, Xi; Sollid, Ludvig M (2014) How T cells taste gluten in celiac disease. Nat Struct Mol Biol 21:429-31

Showing the most recent 10 out of 502 publications