The Tissue Engineering and Cell Models Core (TECM) enables DDRCC investigators to address key questions relating to causality and mechanisms by providing novel and vetted experimental models that can be customized to their needs. It was established 21 months ago, replacing the Genomics and Molecular Engineering (GME) Core of the DDRCC. The reorganization of the Core was a direct result of two sequential annual needs assessments indicating strong interest by the membership for more physiologically-relevant experimental models to study digestive health and diseases. The TECM has three major components: (1) A centralized repository and facility for established and primary gut-relevant cell lines, which was originally part of the host-microbe core, but moved to the TECM to centralize all cell and tissue experimental systems, (2) A tissue engineering component that includes customizing and developing intestinal organoid technologies for specific applications needed by DDRCC users, and (3) an experimental systems component that includes in vivo models (rodent microsurgery and C. elegans), ex vivo models, and live functional assays. Inherent to these services, the TECM provides training and education, opportunities for cost-savings through bulk purchases (serum, disposables, etc), and technical expertise that saves investigators time and insure high quality of services. The TECM is inextricably tied to the other DDRCC cores. The integrated Translational Research (ITR) and the Host-Microbe (HM) cores are essential for providing cells, tissues, and patient samples for establishing the experimental models. The Tissue and Cell Analysis (TCA) core provides investigators with the means to analyze data derived from the model systems. Thus, the TECM Core has had great impact in enabling DDRCC members to advance knowledge in the thematic areas fostered by the DDRCC which focus on the study of IBD, host-microbe interactions, mucosal immunology and inflammation. In the past year, it was used by 86% of the DDRCC membership and was used in 195 peer-reviewed publications or 65% of the total (306) DDRCC-acknowledged publications during this period. The TECM has promoted interaction, collaboration, cost-sharing, and efficient resources utilization, and, at the same time, has enhanced the capabilities of our investigators.

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Center Core Grants (P30)
Project #
5P30DK042086-29
Application #
9617239
Study Section
Special Emphasis Panel (ZDK1)
Project Start
Project End
Budget Start
2018-12-01
Budget End
2019-11-30
Support Year
29
Fiscal Year
2019
Total Cost
Indirect Cost
Name
University of Chicago
Department
Type
DUNS #
005421136
City
Chicago
State
IL
Country
United States
Zip Code
60637
Cockrell, Chase; An, Gary (2017) Sepsis reconsidered: Identifying novel metrics for behavioral landscape characterization with a high-performance computing implementation of an agent-based model. J Theor Biol 430:157-168
Pekow, Joel; Meckel, Katherine; Dougherty, Urszula et al. (2017) miR-193a-3p is a Key Tumor Suppressor in Ulcerative Colitis-Associated Colon Cancer and Promotes Carcinogenesis through Upregulation of IL17RD. Clin Cancer Res 23:5281-5291
Messer, Jeannette S (2017) The cellular autophagy/apoptosis checkpoint during inflammation. Cell Mol Life Sci 74:1281-1296
An, G; Fitzpatrick, B G; Christley, S et al. (2017) Optimization and Control of Agent-Based Models in Biology: A Perspective. Bull Math Biol 79:63-87
Arvans, Donna; Jung, Yong-Chul; Antonopoulos, Dionysios et al. (2017) Oxalobacter formigenes-Derived Bioactive Factors Stimulate Oxalate Transport by Intestinal Epithelial Cells. J Am Soc Nephrol 28:876-887
Nobutani, Kentaro; Miyoshi, Jun; Musch, Mark W et al. (2017) Daikenchuto (TU-100) alters murine hepatic and intestinal drug metabolizing enzymes in an in vivo dietary model: effects of gender and withdrawal. Pharmacol Res Perspect 5:
Messer, J S; Liechty, E R; Vogel, O A et al. (2017) Evolutionary and ecological forces that shape the bacterial communities of the human gut. Mucosal Immunol 10:567-579
Nie, Litong; Shuai, Lin; Zhu, Mingrui et al. (2017) The Landscape of Histone Modifications in a High-Fat Diet-Induced Obese (DIO) Mouse Model. Mol Cell Proteomics 16:1324-1334
Denzin, Lisa K; Khan, Aly A; Virdis, Francesca et al. (2017) Neutralizing Antibody Responses to Viral Infections Are Linked to the Non-classical MHC Class II Gene H2-Ob. Immunity 47:310-322.e7
Alverdy, John C; Luo, James N (2017) The Influence of Host Stress on the Mechanism of Infection: Lost Microbiomes, Emergent Pathobiomes, and the Role of Interkingdom Signaling. Front Microbiol 8:322

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