The Pilot and Feasibility grant program of the Yale DRC is managed through the Pilot and Feasibility Core. The functions of the Core are to solicit applications from investigators in the Yale School of Medicine and throughout Yale University, to carry out peer review of the applications, and to select meritorious projects for support. Grants are awarded for up to 2 years depending on progress that is made in the first year of funding and plans for the 2rd year. The Core is directed by Kevan Herold, MD who works with an oversight committee that makes final funding selections of grants for support. In the past funding cycle, the Program benefited from additional support available through the CTSA/ARRA funds as well as collaborative support of translational studies with the Yale Clinical Translational Science Award (CTSA). Since the inception of the Yale DRC in 1993, interest and applications to the program has increased - in the past funding cycle, 88 applications were received and 28 were supported. While the majority of applications are received from established investigators, there is a bias towards funding new investigators, many of whom have used the P+F award to obtain preliminary data to apply for external grant support. From the past funding cycle, 11 new external grants were obtained generating over $7M in new research revenue. Studies supported by the P+F program have resulted in more than 40 peer-reviewed publications during the last two funding cycles. The P+F program has also been a mechanism for initiation of new collaborations often between basic and translational scientists. Examples of these collaborations include studies of innate immune pathways that are associated with hepatic insulin resistance and cellular mechanisms of glucose metabolism in adipocytes. In summary the P+F core plays a vital role in attracting new investigators to the diabetes field and recruiting established investigators who are new to diabetes or are developing a new area of diabetes-related research. By effectively utilizing additional sources of revenue, the Core has been able to maintain a high level of funding which has resulted in a high level of productivity.

National Institute of Health (NIH)
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Center Core Grants (P30)
Project #
Application #
Study Section
Special Emphasis Panel (ZDK1-GRB-S)
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
Yale University
New Haven
United States
Zip Code
Zhang, Yongdeng; Lara-Tejero, María; Bewersdorf, Jörg et al. (2017) Visualization and characterization of individual type III protein secretion machines in live bacteria. Proc Natl Acad Sci U S A 114:6098-6103
Varela, Luis; Suyama, Shigetomo; Huang, Yan et al. (2017) Endothelial HIF-1? Enables Hypothalamic Glucose Uptake to Drive POMC Neurons. Diabetes 66:1511-1520
Park, Jin-Kyu; Shao, Mingjie; Kim, Moon Young et al. (2017) An endoplasmic reticulum protein, Nogo-B, facilitates alcoholic liver disease through regulation of kupffer cell polarization. Hepatology 65:1720-1734
Thompson, Alexander D; Bewersdorf, Joerg; Toomre, Derek et al. (2017) HIDE Probes: A New Toolkit for Visualizing Organelle Dynamics, Longer and at Super-Resolution. Biochemistry 56:5194-5201
Jelenik, Tomas; Kaul, Kirti; Séquaris, Gilles et al. (2017) Mechanisms of Insulin Resistance in Primary and Secondary Nonalcoholic Fatty Liver. Diabetes 66:2241-2253
Perry, Rachel J; Peng, Liang; Abulizi, Abudukadier et al. (2017) Mechanism for leptin's acute insulin-independent effect to reverse diabetic ketoacidosis. J Clin Invest 127:657-669
Lees, Joshua A; Messa, Mirko; Sun, Elizabeth Wen et al. (2017) Lipid transport by TMEM24 at ER-plasma membrane contacts regulates pulsatile insulin secretion. Science 355:
Chowdhury, Golam M I; Wang, Peili; Ciardi, Alisha et al. (2017) Impaired Glutamatergic Neurotransmission in the Ventromedial Hypothalamus May Contribute to Defective Counterregulation in Recurrently Hypoglycemic Rats. Diabetes 66:1979-1989
Sun, Emily W; de Fontgalland, Dayan; Rabbitt, Philippa et al. (2017) Mechanisms Controlling Glucose-Induced GLP-1 Secretion in Human Small Intestine. Diabetes 66:2144-2149
Lee, Hui-Young; Lee, Jae Sung; Alves, Tiago et al. (2017) Mitochondrial-Targeted Catalase Protects Against High-Fat Diet-Induced Muscle Insulin Resistance by Decreasing Intramuscular Lipid Accumulation. Diabetes 66:2072-2081

Showing the most recent 10 out of 566 publications