This application is for a 5 year renewal of the Colorado Clinical Nutrition Research Unit (CNRU). The Colorado CNRU was originally funded in January, 1995 to serve 41 investigators. Now, in our eleventh year of operation, we serve 67 investigators.The broad goal of the Colorado CNRU is to enhance the nutrition-related research base and to help promising junior scientists with an interest in nutrition, develop into independent investigators. The theme of the Colorado CNRU, nutrient utilization, captures the broad interests of a majority of our research base members. We have identified 4 research focus areas with that broad theme: obesity &diabetes;developmental aspects of nutrition utilization;micronutrient utilization and function and community nutrition. The research supported by the CNRU includes a continuum from the patient or health subject to the subcellular and molecular levels. We propose an Administrative Core and 3 scientific core laboratories: Energy Balance, Mass Spectrometry and Metabolic. The use of core laboratories, the number of CNRU support publications and the federal funding for nutrition research continues to steadily expand. The CNRU Director, Dr. James Hill and the Associate Director, Dr. Dan Bessesen, are supported by a strong Executive Committee. The Colorado CNRU is located at the Center for Human Nutrition (CHN) at the University of Colorado Health Sciences Center. The CHN has strong programs for nutrition education, research training, clinical nutrition services and community outreach. The existence of a CNRU in Colorado has energized an already strong group of nutrition investigators and has led to many exciting new collaborations and interactions, along with gaining recognition both nationally and within our university. We look forward to continuing to enhance nutrition research within Colorado over the next 5 years.

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Center Core Grants (P30)
Project #
5P30DK048520-20
Application #
8730596
Study Section
Special Emphasis Panel (ZDK1-GRB-2 (M2))
Program Officer
Evans, Mary
Project Start
1997-01-01
Project End
2015-07-31
Budget Start
2014-08-01
Budget End
2015-07-31
Support Year
20
Fiscal Year
2014
Total Cost
$1,138,053
Indirect Cost
$377,406
Name
University of Colorado Denver
Department
Pediatrics
Type
Schools of Medicine
DUNS #
041096314
City
Aurora
State
CO
Country
United States
Zip Code
80045
Shapiro, Allison L B; Boyle, Kristen E; Dabelea, Dana et al. (2016) Nicotinamide Promotes Adipogenesis in Umbilical Cord-Derived Mesenchymal Stem Cells and Is Associated with Neonatal Adiposity: The Healthy Start BabyBUMP Project. PLoS One 11:e0159575
Giles, Erin D; Hagman, Jennifer; Pan, Zhaoxing et al. (2016) Weight restoration on a high carbohydrate refeeding diet promotes rapid weight regain and hepatic lipid accumulation in female anorexic rats. Nutr Metab (Lond) 13:18
Sladek, Celia D; Stevens, Wanida; Song, Zhilin et al. (2016) The "metabolic sensor" function of rat supraoptic oxytocin and vasopressin neurons is attenuated during lactation but not in diet-induced obesity. Am J Physiol Regul Integr Comp Physiol 310:R337-45
Zhang, Ping; Hire, Don; Espeland, Mark A et al. (2016) Impact of intensive lifestyle intervention on preference-based quality of life in type 2 diabetes: Results from the Look AHEAD trial. Obesity (Silver Spring) 24:856-64
Hernandez, Teri L; Van Pelt, Rachael E; Anderson, Molly A et al. (2016) Women With Gestational Diabetes Mellitus Randomized to a Higher-Complex Carbohydrate/Low-Fat Diet Manifest Lower Adipose Tissue Insulin Resistance, Inflammation, Glucose, and Free Fatty Acids: A Pilot Study. Diabetes Care 39:39-42
Giles, Erin D; Steig, Amy J; Jackman, Matthew R et al. (2016) Exercise Decreases Lipogenic Gene Expression in Adipose Tissue and Alters Adipocyte Cellularity during Weight Regain After Weight Loss. Front Physiol 7:32
Boyle, Kristen E; Patinkin, Zachary W; Shapiro, Allison L B et al. (2016) Mesenchymal Stem Cells From Infants Born to Obese Mothers Exhibit Greater Potential for Adipogenesis: The Healthy Start BabyBUMP Project. Diabetes 65:647-59
Pereira, Rocio I; Low Wang, Cecilia C; Wolfe, Pamela et al. (2016) Associations of Adiponectin with Adiposity, Insulin Sensitivity, and Diet in Young, Healthy, Mexican Americans and Non-Latino White Adults. Int J Environ Res Public Health 13:ijerph13010054
Action for Health in Diabetes (Look AHEAD) Study Group (2016) Association of Weight Loss Maintenance and Weight Regain on 4-Year Changes in CVD Risk Factors: the Action for Health in Diabetes (Look AHEAD) Clinical Trial. Diabetes Care 39:1345-55
Wang, Hong; Wang, Yongping; Taussig, Matthew D et al. (2016) Sex differences in obesity development in pair-fed neuronal lipoprotein lipase deficient mice. Mol Metab 5:1025-32

Showing the most recent 10 out of 521 publications