The University of Pennsylvania's Digestive Diseases Research Core Center (DDRCC), entitled Center for Molecular Studies in Digestive and Liver Diseases (CMSDLD), has been funded since 1997. This competing grant proposal continues to unite investigators from multiple disciplines for integrative digestive, live and pancreatic based research. The research base includes investigators organized in the following three interrelated scientific affinity groups: (l) Developmental biology and regenerative medicine, (2) lmmunobiology and host responses, and (3) Cell growth and differentiation. The research base consists of 58 members, with interrelated scientific programs, and represents a spectrum of Departments, Centers, Institutes, and Schools at the University of Pennsylvania and surrounding Institutions. In addition, there is a young investigator base of 11 associate members, whose own individual programs and career development are nurtured by the Center. Center members are supported by $27,301,051 in digestive-diseases related NIH research funding, of which 60% is through NIDDK. A fundamental goal of our Center is to foster interdisciplinary research that leads to a cooperative understanding of the molecular and biochemical processes that form, regulate, and operate digestive tract, pancreatic and liver organs and their organizing tissues in health and disease. In this context, our intent is to utiliz the Center as a means to develop innovative ideas by attracting and engaging established investigators into digestive, liver and pancreatic research. An equally important goal of the Center is to develop young investigators in this research. Four highly successful Scientific Core facilities are designed to provide digestive-specific services for the stimulation of collaborative research: Molecular Biology/Gene Expression, Molecular Pathology and Imaging, Transgenic and Chimeric Mouse and Cell Culture. An Administrative Core directs the fiscal and organizational aspects of the Center, including the coordination and publicity of the scientific cores, pilot and feasibility (P/F) grant program, academic enrichment program and Internal/External Advisory committees. Our DDRCC's aggregate functions maintain the digestive, liver and pancreatic programs at the forefront of biomedical science.

Public Health Relevance

The Penn DDRCC or CMSDLD comprises an integrated and interdisciplinary research base dedicated to the enhancement of our understanding of normal digestive, liver and pancreatic health as well as diseases that arise from these organs. Scientific core facilities, P/F grants and enrichment programs provide a rich platform of technologies, services and interactions to promote the collaborative research efforts of CMSDLD members and associate members.

Agency
National Institute of Health (NIH)
Type
Center Core Grants (P30)
Project #
5P30DK050306-18
Application #
8675836
Study Section
Special Emphasis Panel (ZDK1)
Program Officer
Grey, Michael J
Project Start
Project End
Budget Start
Budget End
Support Year
18
Fiscal Year
2014
Total Cost
Indirect Cost
Name
University of Pennsylvania
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
City
Philadelphia
State
PA
Country
United States
Zip Code
19104
Agarwalla, Anant; Small, Aaron J; Mendelson, Aaron H et al. (2015) Risk of recurrent or refractory strictures and outcome of endoscopic dilation for radiation-induced esophageal strictures. Surg Endosc 29:1903-12
Bunchorntavakul, Chalermrat; Jones, Lisa M; Kikuchi, Masahiro et al. (2015) Distinct features in natural history and outcomes of acute hepatitis C. J Clin Gastroenterol 49:e31-40
Banerjee, Shuvomoy; Jha, Hem Chandra; Robertson, Erle S (2015) Regulation of the metastasis suppressor Nm23-H1 by tumor viruses. Naunyn Schmiedebergs Arch Pharmacol 388:207-24
Kagawa, S; Natsuizaka, M; Whelan, K A et al. (2015) Cellular senescence checkpoint function determines differential Notch1-dependent oncogenic and tumor-suppressor activities. Oncogene 34:2347-59
Dzeng, Richard K; Jha, Hem Chandra; Lu, Jie et al. (2015) Small molecule growth inhibitors of human oncogenic gammaherpesvirus infected B-cells. Mol Oncol 9:365-76
Bhattacharya, Sabyasachi; Katlinski, Kanstantsin V; Reichert, Maximilian et al. (2014) Triggering ubiquitination of IFNAR1 protects tissues from inflammatory injury. EMBO Mol Med 6:384-97
Natsuizaka, Mitsuteru; Kinugasa, Hideaki; Kagawa, Shingo et al. (2014) IGFBP3 promotes esophageal cancer growth by suppressing oxidative stress in hypoxic tumor microenvironment. Am J Cancer Res 4:29-41
Lu, Jie; Jha, Hem C; Verma, Subhash C et al. (2014) Kaposi's sarcoma-associated herpesvirus-encoded LANA contributes to viral latent replication by activating phosphorylation of survivin. J Virol 88:4204-17
Hill, D A; Siracusa, M C; Ruymann, K R et al. (2014) Omalizumab therapy is associated with reduced circulating basophil populations in asthmatic children. Allergy 69:674-7
Rustgi, Anil K (2014) Familial pancreatic cancer: genetic advances. Genes Dev 28:1-7

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