The mission ofthe Minnesota Obesity Center is to find ways to prevent weight gain, and the onset of obesity and complications of obesity. Obesity is a major source of illness and death, and is the most common nutritional ailment in the United States. Little is known about effective measures to prevent obesity. Obese individuals can more easily lose weight than maintain the loss. Prevention of initial weight gain should be emphasized, and failing that, prevention of regain after weight loss. Four goals are established: 1) find the underlying problems that lead to obesity, 2) identify behaviors that lead to obesity and find ways to help change those behaviors, 3) seek means to prevent obesity-related co-morbidities and 4) determine public health and public policy measures that will reduce the frequency and severity of obesity. The Center will promote studies directed at these aims by: assisting principal investigators in conducting relevant research by providing resources through the core system;stimulating new interest and collaborations in research into obesity, eating disorders and energy metabolism;supporting new research in these areas related to obesity; and supporting education in obesity and eating disorders in the academic and public communities. The research base consists of 75 investigators with 137 funded projects generating over 34 million dollars per year in grant support. Five cores are proposed: 1) Administration will provide vision, leadership, and oversight of other core activities, 2) Molecular and Cellular Basis of Obesity Core will assist investigators pursuing research projects on the fundamental mechanisms that control or affect adiposity and energy metabolism, 3) Disordered Eating Assessment Core will assist in the assessment of disordered eating and other psychopathology, and the development of interventions for such disordered eating, 4) Epidemiology and Intervention Core is to make high quality services for epidemiological and behavioral intervention studies available, 5) Metabolic Studies Core Laboratory will provide access to established and state-of-the-art methods for studying energy metabolism and nutrient partitioning at the whole body level. Resources for oilot/feasibilitv proiects and an educational program will be established.

Public Health Relevance

The Minnesota Obesity Center's mission is to find ways to prevent weight gain, obesity and the complications of obesity. Obesity is a major source of illness and death, and is the most important public health problem in the U.S. Despite its prevalence, little is known about effective measures to prevent obesity and its attendant complications. The Center will support work focused on prevention of initial weight gain, prevention of regain after weight loss, and prevention of obesity complications.

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Center Core Grants (P30)
Project #
5P30DK050456-17
Application #
8251203
Study Section
Special Emphasis Panel (ZDK1-GRB-2 (J2))
Program Officer
Evans, Mary
Project Start
1997-09-01
Project End
2016-03-31
Budget Start
2012-04-01
Budget End
2013-03-31
Support Year
17
Fiscal Year
2012
Total Cost
$1,146,765
Indirect Cost
$299,704
Name
University of Minnesota Twin Cities
Department
Nutrition
Type
Schools of Earth Sciences/Natur
DUNS #
555917996
City
Minneapolis
State
MN
Country
United States
Zip Code
55455
Ho, Yen-Yi; Starr, Timothy K; LaRue, Rebecca S et al. (2016) Case-oriented pathways analysis in pancreatic adenocarcinoma using data from a sleeping beauty transposon mutagenesis screen. BMC Med Genomics 9:16
Santosa, Sylvia; Bonnes, Sara L; Jensen, Michael D (2016) Acute Female Hypogonadism Alters Adipose Tissue Fatty Acid Storage Factors and Chylomicronemia. J Clin Endocrinol Metab 101:2089-98
Veldhuis, Johannes; Yang, Rebecca; Roelfsema, Ferdinand et al. (2016) Proinflammatory Cytokine Infusion Attenuates LH's Feedforward on Testosterone Secretion: Modulation by Age. J Clin Endocrinol Metab 101:539-49
Haynos, Ann F; Berg, Kelly C; Cao, Li et al. (2016) Trajectories of Higher- and Lower-Order Dimensions of Negative and Positive Affect Relative to Restrictive Eating in Anorexia Nervosa. J Abnorm Psychol :
Ryder, Justin R; O'Connell, Michael; Bosch, Tyler A et al. (2016) Impaired cardiac autonomic nervous system function is associated with pediatric hypertension independent of adiposity. Pediatr Res 79:49-54
Pearson, Carolyn M; Pisetsky, Emily M; Goldschmidt, Andrea B et al. (2016) Personality psychopathology differentiates risky behaviors among women with bulimia nervosa. Int J Eat Disord 49:681-8
Veldhuis, Johannes D; Dyer, Roy B; Trushin, Sergey A et al. (2016) Interleukins 6 and 8 and abdominal fat depots are distinct correlates of lipid moieties in healthy pre- and postmenopausal women. Endocrine 54:671-680
Fox, Claudia K; Kaizer, Alexander M; Rudser, Kyle D et al. (2016) Meal replacements followed by topiramate for the treatment of adolescent severe obesity: A pilot randomized controlled trial. Obesity (Silver Spring) 24:2553-2561
Konopka, Adam R; Esponda, Raul Ruiz; Robinson, Matthew M et al. (2016) Hyperglucagonemia Mitigates the Effect of Metformin on Glucose Production in Prediabetes. Cell Rep 15:1394-400
Accurso, Erin C; Wonderlich, Stephen A; Crosby, Ross D et al. (2016) Predictors and moderators of treatment outcome in a randomized clinical trial for adults with symptoms of bulimia nervosa. J Consult Clin Psychol 84:178-84

Showing the most recent 10 out of 661 publications