The Molecular and Cellular Basis for Obesity Core is a broadly based research and technology center that emphasizes the genes, proteins and metabolites linked to obesity and obesity-related disease. Dr. David Bernlohr, PhD, is the Core Director. Dr. Bernlohr is Professor and Head of the Department of Biochemistry, Molecular Biology and Biophysics at the University of Minnesota. He is the recipient of a Distinguished McKnight University Professorship and holds the Cargill Chair in Systems Biology of Human Metabolism. Dr.Bernlohr has served the scientific community in a number of capacities. He has served on the editorial boards for the Journal of Biological Chemistry, Protein Science and the Journal of Lipid Research. He finished his second term as a permanent member ofthe Integrated Physiology of Obesity and Diabetes (IPOD) Study Section and was (ihair of IPOD from 2008-2009. Dr. Bernlohr holds multiple NIH awards and has studied adipose biology his entire professional career. His primary research themes involve the role of fatty acid binding proteins and fatty acid transporters in adipocyte and macrophage metabolism, oxidative stress and mitochondrial metabolism and the role of inflammation in obesity. He uses a combination of genomic, proteomic and metabolomic methodologies in his studies and uses a variety of cell based and animal models (knockout and transgenic) in his work. He is ideally suited to be Core Director for his experimental expertise utilizes all the Core technologies and he is able to address questions plus serve as a mentor for others interested in basic obesity research. Dr. Bernlohr will devote 5% of his effort to directing the Core and will be responsible for: Overseeing all budgetary and scientific activities of the Core Representing the Core on the Center Executive Committee Preparing all Core reports and providing information on Core activities to the Center Director Evaluating Core usage and needs and planning for future development Organizing the Core Research Club Assisting in the oversight of the Gene Expression and Analysis Subcore, especially with regard to development and use of lentiviral vectors. The Core will be organized into three primary subcores with each one having a subcore leader.

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Center Core Grants (P30)
Project #
5P30DK050456-19
Application #
8640145
Study Section
Special Emphasis Panel (ZDK1)
Project Start
Project End
Budget Start
2014-04-01
Budget End
2015-03-31
Support Year
19
Fiscal Year
2014
Total Cost
Indirect Cost
Name
University of Minnesota Twin Cities
Department
Type
DUNS #
City
Minneapolis
State
MN
Country
United States
Zip Code
55455
Ho, Yen-Yi; Starr, Timothy K; LaRue, Rebecca S et al. (2016) Case-oriented pathways analysis in pancreatic adenocarcinoma using data from a sleeping beauty transposon mutagenesis screen. BMC Med Genomics 9:16
Santosa, Sylvia; Bonnes, Sara L; Jensen, Michael D (2016) Acute Female Hypogonadism Alters Adipose Tissue Fatty Acid Storage Factors and Chylomicronemia. J Clin Endocrinol Metab 101:2089-98
Veldhuis, Johannes; Yang, Rebecca; Roelfsema, Ferdinand et al. (2016) Proinflammatory Cytokine Infusion Attenuates LH's Feedforward on Testosterone Secretion: Modulation by Age. J Clin Endocrinol Metab 101:539-49
Haynos, Ann F; Berg, Kelly C; Cao, Li et al. (2016) Trajectories of Higher- and Lower-Order Dimensions of Negative and Positive Affect Relative to Restrictive Eating in Anorexia Nervosa. J Abnorm Psychol :
Ryder, Justin R; O'Connell, Michael; Bosch, Tyler A et al. (2016) Impaired cardiac autonomic nervous system function is associated with pediatric hypertension independent of adiposity. Pediatr Res 79:49-54
Pearson, Carolyn M; Pisetsky, Emily M; Goldschmidt, Andrea B et al. (2016) Personality psychopathology differentiates risky behaviors among women with bulimia nervosa. Int J Eat Disord 49:681-8
Veldhuis, Johannes D; Dyer, Roy B; Trushin, Sergey A et al. (2016) Interleukins 6 and 8 and abdominal fat depots are distinct correlates of lipid moieties in healthy pre- and postmenopausal women. Endocrine 54:671-680
Fox, Claudia K; Kaizer, Alexander M; Rudser, Kyle D et al. (2016) Meal replacements followed by topiramate for the treatment of adolescent severe obesity: A pilot randomized controlled trial. Obesity (Silver Spring) 24:2553-2561
Konopka, Adam R; Esponda, Raul Ruiz; Robinson, Matthew M et al. (2016) Hyperglucagonemia Mitigates the Effect of Metformin on Glucose Production in Prediabetes. Cell Rep 15:1394-400
Accurso, Erin C; Wonderlich, Stephen A; Crosby, Ross D et al. (2016) Predictors and moderators of treatment outcome in a randomized clinical trial for adults with symptoms of bulimia nervosa. J Consult Clin Psychol 84:178-84

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