Never has there been a more exciting time in the history of genetics and genomics research than today. Genomic technologies are advancing on a daily basis, with better, faster, and cheaper methodologies being developed at an astounding rate. As such, genomic discovery is also advancing at an unprecedented pace. The NORC Genomics Core (GC), led by Drs. Molly Bray and Jose Fernandez, provides the critic^al capacity to examine the effects of genetic variation and gene function on obesity outcomes by making available advanced methodologies for genetic and genomic studies of obesity and nutrition for NORC investigators. Since its inception in 2000, the Genomics Core (formerly, the Genetics Core) has provided services for preparation and banking of study samples and the characterization of DNA sequence. In the past funding cycle, the NORC Genomics Core has supported 32 investigators, 25 federally funded projects, and nine pilot projects, resulting in 55 publications. Through new collaborations and expanded genomics resources recently acquired by UAB (described below), we now have the capacity to provide a wider range of genomics services to our member base, including whole genome genotyping, gene expression, and methylation arrays, low and high throughput custom genotyping and gene expression, and standard and next generation sequencing (NGS). Beyond our technological capabilities, the Genomics Core directors, Drs. Bray and Fernandez, can provide not only guidance on selection of genomic assays and analyses but are also experts in obesity genetics, intervention response phenotypes, and genetic admixture. This specialized knowledge enhances the Genomics Core's value by providing both methodologic and content expertise

National Institute of Health (NIH)
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Center Core Grants (P30)
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Special Emphasis Panel (ZDK1-GRB-2)
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University of Alabama Birmingham
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George, Brandon J; Li, Peng; Lieberman, Harris R et al. (2018) Randomization to randomization probability: Estimating treatment effects under actual conditions of use. Psychol Methods 23:337-350
Ejima, Keisuke; Thomas, Diana M; Allison, David B (2018) A Mathematical Model for Predicting Obesity Transmission with Both Genetic and Nongenetic Heredity. Obesity (Silver Spring) 26:927-933
Dhurandhar, Emily J; Pavela, Gregory; Kaiser, Kathryn A et al. (2018) Body Mass Index and Subjective Social Status: The Coronary Artery Risk Development in Young Adults Study. Obesity (Silver Spring) 26:426-431
Schneider, C R; Biggio, J R; Chandler-Laney, P C (2018) Association of early pregnancy body mass index with post-partum weight change among African-American women. Clin Obes 8:170-175
Kim, Teayoun; Nason, Shelly; Holleman, Cassie et al. (2018) Glucagon Receptor Signaling Regulates Energy Metabolism via Hepatic Farnesoid X Receptor and Fibroblast Growth Factor 21. Diabetes 67:1773-1782
Borges, Juliano H; Carter, Stephen J; Singh, Harshvardhan et al. (2018) Inverse relationship between changes of maximal aerobic capacity and changes in walking economy after weight loss. Eur J Appl Physiol :
Nelson, Jordan R; Schwartz, Tonia S; Gohlke, Julia M (2018) Influence of maternal age on the effects of seleno-l-methionine in the model organism Daphnia pulex under standard and heat stress conditions. Reprod Toxicol 75:1-9
Speed, Joshua S; Hyndman, Kelly A; Roth, Kaehler et al. (2018) High dietary sodium causes dyssynchrony of the renal molecular clock in rats. Am J Physiol Renal Physiol 314:F89-F98
Dickinson, Stephanie L; Brown, Andrew W; Mehta, Tapan et al. (2018) Incorrect analyses were used in ""Different enteral nutrition formulas have no effect on glucose homeostasis but on diet-induced thermogenesis in critically ill medical patients: a randomized controlled trial"" and corrected analyses are requested. Eur J Clin Nutr :
Davis, Rachel A H; Plaisance, Eric P; Allison, David B (2018) Complementary Hypotheses on Contributors to the Obesity Epidemic. Obesity (Silver Spring) 26:17-21

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