Never has there been a more exciting time in the history of genetics and genomics research than today. Genomic technologies are advancing on a daily basis, with better, faster, and cheaper methodologies being developed at an astounding rate. As such, genomic discovery is also advancing at an unprecedented pace. The NORC Genomics Core (GC), led by Drs. Molly Bray and Jose Fernandez, provides the critic^al capacity to examine the effects of genetic variation and gene function on obesity outcomes by making available advanced methodologies for genetic and genomic studies of obesity and nutrition for NORC investigators. Since its inception in 2000, the Genomics Core (formerly, the Genetics Core) has provided services for preparation and banking of study samples and the characterization of DNA sequence. In the past funding cycle, the NORC Genomics Core has supported 32 investigators, 25 federally funded projects, and nine pilot projects, resulting in 55 publications. Through new collaborations and expanded genomics resources recently acquired by UAB (described below), we now have the capacity to provide a wider range of genomics services to our member base, including whole genome genotyping, gene expression, and methylation arrays, low and high throughput custom genotyping and gene expression, and standard and next generation sequencing (NGS). Beyond our technological capabilities, the Genomics Core directors, Drs. Bray and Fernandez, can provide not only guidance on selection of genomic assays and analyses but are also experts in obesity genetics, intervention response phenotypes, and genetic admixture. This specialized knowledge enhances the Genomics Core's value by providing both methodologic and content expertise

National Institute of Health (NIH)
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Center Core Grants (P30)
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Special Emphasis Panel (ZDK1-GRB-2)
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University of Alabama Birmingham
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Kyle, Theodore K; Dhurandhar, Emily J; Allison, David B (2016) Regarding Obesity as a Disease: Evolving Policies and Their Implications. Endocrinol Metab Clin North Am 45:511-20
Kaiser, Kathryn A; Parman, Mariel A; Kim, Eric et al. (2016) Potential Errors and Omissions Related to the Analysis and Conclusions Reported in Cuspidi C, et al., AJH 2014; 27(2):146-156. Am J Hypertens 29:780-1
Lewis Jr, D W; Fields, D A; Allison, D B (2016) Inconsistencies and inaccuracies in reporting on choice of endpoints and of statistical results in RCT of maternal diet. Pediatr Obes 11:e16-e17
Liu, Jian; Wang, Peipei; Douglas, Samuel L et al. (2016) Impact of high-fat, low-carbohydrate diet on myocardial substrate oxidation, insulin sensitivity, and cardiac function after ischemia-reperfusion. Am J Physiol Heart Circ Physiol 311:H1-H10
Frihauf, Jennifer B; Fekete, Eva M; Nagy, Tim R et al. (2016) Maternal Western diet increases adiposity even in male offspring of obesity-resistant rat dams: early endocrine risk markers. Am J Physiol Regul Integr Comp Physiol :ajpregu.00023.2016
Milner, Adrienne N; George, Brandon J; Allison, David B (2016) Black and Hispanic Men Perceived to Be Large Are at Increased Risk for Police Frisk, Search, and Force. PLoS One 11:e0147158
Joseph, Rodney P; Pekmezi, Dori; Dutton, Gareth R et al. (2016) Results of a Culturally Adapted Internet-Enhanced Physical Activity Pilot Intervention for Overweight and Obese Young Adult African American Women. J Transcult Nurs 27:136-46
Heyward, Frankie D; Gilliam, Daniel; Coleman, Mark A et al. (2016) Obesity Weighs down Memory through a Mechanism Involving the Neuroepigenetic Dysregulation of Sirt1. J Neurosci 36:1324-35
Roth, David L; Skarupski, Kimberly A; Crews, Deidra C et al. (2016) Distinct age and self-rated health crossover mortality effects for African Americans: Evidence from a national cohort study. Soc Sci Med 156:12-20
Reese, Jasmine M; Joseph, Rodney P; Cherrington, Andrea et al. (2016) Development of Participant-Informed Text Messages to Promote Physical Activity Among African American Women Attending College: A Qualitative Mixed-Methods Inquiry. J Transcult Nurs :

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