This application is submitted in response to RFA DK-04-014, Silvio O. Conte Digestive Diseases Research Core Center, requesting continued funding of the Texas Gulf Coast Digestive Diseases Center (called DDC for simplicity). This Center serves basic and clinical scientists at institutions within the Texas Medical Center (Baylor College of Medicine, The University of Texas Health Science Center at Houston) and at the University of Texas Medical Branch in Galveston. Our qualifying Funded Research Base is $22,182,225 million (direct costs) and includes 44 separate awards from NIDDK totaling $9,016,286 million (direct costs). Reflecting the goals of these projects, this is a Center for Gastrointestinal Development, Infection and Injury. This Center was developed from a core group of investigators who began interacting formally in 1996, to explore the need and interest in establishing a DDC. These interactions were initiated by a Pediatric Training Program in Gastroenterology at Baylor whose faculty represent key investigators in our DDC. Institutional resource commitments in space, funds and personnel support this effort, including new positions in basic and clinical departments for multidiscliplinary, independent, faculty to establish new research programs. This Center facilitates on-going Digestive Diseases research, promotes translational research between basic and clinical areas, develops new projects, nurtures new investigators, and provides GI educational activities. Support is requested for an Administrative Core, four Basic Science Cores (Morphology, Gene Expression and Proteomics, Gastrointestinal Immunology, Integrative Biology) and one Clinical Core (Study Design and Clinical Research Support). Pilot/Feasibility and Enrichment Programs, including a Career Development Initiative, to support innovative ideas and new investigators in Digestive Disease research and foster collaboration are a key part of the DDC, and have been extremely successful The Center draws together a multidisciplinary group of investigators, including basic scientists with proven track records of success, and well-coordinated clinical programs dealing with pediatric and adult GI patients. Center leaders are senior scientists-administrators experienced in directing interactive, multidisciplinary programs. A large, multi-ethnic population of infants and adults with Digestive Diseases emphasizes the need and the opportunities for this Center. Various groups involved in GI research and education in the Gulf Coast Area of Texas have shown the willingness to enthusiastically work with the Center. This NIDDK-funded DDRCC will promote and coordinate Digestive Disease activities in the area.

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Center Core Grants (P30)
Project #
5P30DK056338-10
Application #
8230735
Study Section
Special Emphasis Panel (ZDK1-GRB-8 (O1))
Program Officer
Podskalny, Judith M,
Project Start
1999-12-01
Project End
2013-02-28
Budget Start
2012-03-01
Budget End
2013-02-28
Support Year
10
Fiscal Year
2012
Total Cost
$1,148,666
Indirect Cost
$361,451
Name
Baylor College of Medicine
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
051113330
City
Houston
State
TX
Country
United States
Zip Code
77030
Chen, Deliang; Oezguen, Numan; Urvil, Petri et al. (2016) Regulation of protein-ligand binding affinity by hydrogen bond pairing. Sci Adv 2:e1501240
Chumpitazi, Bruno P; Weidler, Erica M; Shulman, Robert J (2016) Lactulose Breath Test Gas Production in Childhood IBS is Associated with Intestinal Transit and Bowel Movement Frequency. J Pediatr Gastroenterol Nutr :
Mayo, Sara A; Song, Ye K; Cruz, Melissa R et al. (2016) Indomethacin injury to the rat small intestine is dependent upon biliary secretion and is associated with overgrowth of enterococci. Physiol Rep 4:
Graham, David Y; Dore, Maria Pina (2016) Helicobacter pylori therapy: a paradigm shift. Expert Rev Anti Infect Ther 14:577-85
Ross, Caná L; Spinler, Jennifer K; Savidge, Tor C (2016) Structural and functional changes within the gut microbiota and susceptibility to Clostridium difficile infection. Anaerobe 41:37-43
Georgescu, Maria-Magdalena; Gagea, Mihai; Cote, Gilbert (2016) NHERF1/EBP50 Suppresses Wnt-β-Catenin Pathway-Driven Intestinal Neoplasia. Neoplasia 18:512-23
Spinler, Jennifer K; Ross, Caná L; Savidge, Tor C (2016) Probiotics as adjunctive therapy for preventing Clostridium difficile infection - What are we waiting for? Anaerobe 41:51-57
Wang, Yaohong; George, Sudeep P; Roy, Swati et al. (2016) Both the anti- and pro-apoptotic functions of villin regulate cell turnover and intestinal homeostasis. Sci Rep 6:35491
Meadows, A; Lee, J H; Wu, C-S et al. (2016) Deletion of G-protein-coupled receptor 55 promotes obesity by reducing physical activity. Int J Obes (Lond) 40:417-24
Khan, Anam; Tansel, Aylin; White, Donna L et al. (2016) Efficacy of Psychosocial Interventions in Inducing and Maintaining Alcohol Abstinence in Patients With Chronic Liver Disease: A Systematic Review. Clin Gastroenterol Hepatol 14:191-202.e1-4; quiz e20

Showing the most recent 10 out of 939 publications