The Integrative Biology Core provides training and service to the members ofthe Texas Medical Center Digestive Diseases Research Core Center (DDC) and their research staff in: 1) animal surgery of the gastrointestinal (Gl) tract;2) physiological measurements of Gl properties utilizing both in vivo and in vitro systems;3) the development of animal models of digestive diseases;4) cell isolation;5) whole animal imaging techniques to non-invasively detect functional and anatomical abnormalities, and to monitor the traffic and distribution of biomarkers, drugs and microorganisms. Drs. Lichtenberger and Uray at UTHSC have expertise in the field of Gl physiology and pharmacology, specializing in the in vivo and in vitro models of Gl secretion, barrier function and Gl smooth muscle function, and have developed a number of animal models in their laboratories to study pathophysiological mechanisms of digestive diseases. Dr. Smith, a Collaborator, will bring expertise in animal surgery to the Core and provide assistance and training to members ofthe Center whose research requires animal handling and/or surgery and will provide assistance in issues related to IRB approval for research on laboratory animals. Dr. Thevananther will provide a valuable serve to members of the DDC who require isolated rodent hepatocytes and Kupffer cells for culture or other in vitro studies, with Kupffer cell isolation being a new service. We have also added a new service to assist DDC members in the growth and study Gl organoids in culture. Another service offered to members of the DDC will be to provide assistance with whole animal imaging to non-invasively detect alterations in structure and function, and to monitor the movement of molecular tracers, which has been used successfully to monitor Gl motility and barrier properties. The Integrative Biology Core aims to assist the members ofthe Center in the development of the required techniques utilizing laboratory animals and tissues to accomplish their research goals. In addition to the Directors, the services of an experienced Animal Physiological &Surgical Technician will provide hands on training of members ofthe DDC in accordance to a prioritization schedule to assure the development of junior investigators. The staff of the Integrative Biology Core will also serve to facilitate interactions and collaborations between members ofthe Center.
This Core offers training and expertise to assess physiological responses in animals or tissues. It helps develop new animal models of digestive diseases and non-invasive methods to monitor animals. Finally it provides hepatocytes and organoids to investigators.
|Ha, Kyungsoo; Ma, Chengxian; Lin, Han et al. (2017) The anaphase promoting complex impacts repair choice by protecting ubiquitin signalling at DNA damage sites. Nat Commun 8:15751|
|Desai, Moreshwar S; Mathur, Bhoomika; Eblimit, Zeena et al. (2017) Bile acid excess induces cardiomyopathy and metabolic dysfunctions in the heart. Hepatology 65:189-201|
|Mindikoglu, Ayse L; Pappas, Stephen C (2017) New Developments in Hepatorenal Syndrome. Clin Gastroenterol Hepatol :|
|Wei, Qiong; Lee, Jong Han; Wang, Hongying et al. (2017) Adiponectin is required for maintaining normal body temperature in a cold environment. BMC Physiol 17:8|
|Tanaka, Shingo; Nagashima, Hiroyuki; Cruz, Modesto et al. (2017) Interleukin-17C in Human Helicobacter pylori Gastritis. Infect Immun 85:|
|Lo, Yuan-Hung; Chung, Eunah; Li, Zhaohui et al. (2017) Transcriptional Regulation by ATOH1 and its Target SPDEF in the Intestine. Cell Mol Gastroenterol Hepatol 3:51-71|
|Hollier, John M; Czyzewski, Danita I; Self, Mariella M et al. (2017) Pediatric Irritable Bowel Syndrome Patient and Parental Characteristics Differ by Care Management Type. J Pediatr Gastroenterol Nutr 64:391-395|
|Martin, Camilia R; Stoll, Barbara; Cluette-Brown, Joanne et al. (2017) Use of a novel docosahexaenoic acid formulation vs control in a neonatal porcine model of short bowel syndrome leads to greater intestinal absorption and higher systemic levels of DHA. Nutr Res 39:51-60|
|Vernetti, Lawrence; Gough, Albert; Baetz, Nicholas et al. (2017) Functional Coupling of Human Microphysiology Systems: Intestine, Liver, Kidney Proximal Tubule, Blood-Brain Barrier and Skeletal Muscle. Sci Rep 7:42296|
|Figueroa, Elizabeth; Bugga, Pallavi; Asthana, Vishwaratn et al. (2017) A mechanistic investigation exploring the differential transfection efficiencies between the easy-to-transfect SK-BR3 and difficult-to-transfect CT26 cell lines. J Nanobiotechnology 15:36|
Showing the most recent 10 out of 1007 publications