instructions): The mlsslon of the Pllot and Feasibility Program at the UCSD/UCLA DRC is to foster the development of new invesfigators and provide seed support for high-risk diabetes-related research projects with an emphasis on translational science. The core is directed by Dr. Pinchas Cohen, who is also DRC Associate Director, and a member of the Nafional Diabetes Centers Directors Executive Committee. Over the last decade, the program funded 41 scienfists (28 over the last 5 years, facilitated by an ARRA supplement to the DRC for the support of P&F projects), over 90% of which have been young investigators and more that 95% of them are still active in diabetes research. These investigators garnered an impressive post-funding record of addifional NIH support and published a large amount of papers in high impact journals. These achievements underscore the exceptional pipeline of young investigators that exists in our insfitufions. Specific Objecfives for the P&F Program in this compefifive renewal applicafion are to confinue to: ?promote emerging diabetes projects and future scientific leaders;advertise, inform and engage the diabetes research communifies regarding the DRC P&F and its opportunifies;facilitate and speed transition to external funding;leverage institutional matching support, infrastructure, and technologies towards the success of P&F projects;synergize with other institutional training and research programs;create access for emerging diabetes researchers to the latest research technologies and state-of-the-art facilities and services; foster collaborative research among junior and senior scientists;promote leadership skills;and implement oversight and programmatic review of the P&F program and its awardees. We propose to fund five $50,000 grants each year to provide support for collecfing preliminary data sufficient to support ROI grant applicafions with a focus on newer invesfigators and translafional research. We have established a process of advertising, solicifing, reviewing, awarding, and (if necessary) terminafing P&F projects. This program is assisted by mulfiple experienced external reviewers. We leveraged substanfial institufional matching support from all of the institutions that comprise the DRC, to support promising proposals. Using this institutional matching support, each year, we will fund a sixth, $50,000 P&F award;and one grant per year will be identified as a "junior faculty developmental award" and will receive an addifional $25,000 in year one and will also receive institufional support of $50,000 for a second year. Finally, we will support P&F awards with $10,000 of credit towards use in DRC cores. .
Given the Strong leadership ofthe UCSD/UCLA P&F Program;the innovative ancillary programs available to the awardees, and the emphasis on supporting young investigators that have a remarkable record of success, we expect this program to enable us to substantially advance our goal of continuing our strong track record of producing independent investigators performing cutting-edge translational diabetes research. This will promote the continued advancement of diabetes care and research regionally and nationally.
|Sen, Supriya; Langiewicz, Magda; Jumaa, Hassan et al. (2015) Deletion of serine/arginine-rich splicing factor 3 in hepatocytes predisposes to hepatocellular carcinoma in mice. Hepatology 61:171-83|
|Chung, H; Lee, Y S; Mayoral, R et al. (2015) Omega-3 fatty acids reduce obesity-induced tumor progression independent of GPR120 in a mouse model of postmenopausal breast cancer. Oncogene 34:3504-13|
|Adar, Sara D; Kaufman, Joel D; Diez-Roux, Ana V et al. (2015) Air pollution and percent emphysema identified by computed tomography in the Multi-Ethnic study of Atherosclerosis. Environ Health Perspect 123:144-51|
|Weizman, Adam; Huang, Brian; Berel, Dror et al. (2014) Clinical, serologic, and genetic factors associated with pyoderma gangrenosum and erythema nodosum in inflammatory bowel disease patients. Inflamm Bowel Dis 20:525-33|
|Baker, Michael E; Hardiman, Gary (2014) Transcriptional analysis of endocrine disruption using zebrafish and massively parallel sequencing. J Mol Endocrinol 52:R241-56|
|Huang, Jie; Huffman, Jennifer E; Yamakuchi, Munekazu et al. (2014) Genome-wide association study for circulating tissue plasminogen activator levels and functional follow-up implicates endothelial STXBP5 and STX2. Arterioscler Thromb Vasc Biol 34:1093-101|
|Bis, Joshua C; White, Charles C; Franceschini, Nora et al. (2014) Sequencing of 2 subclinical atherosclerosis candidate regions in 3669 individuals: Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) Consortium Targeted Sequencing Study. Circ Cardiovasc Genet 7:359-64|
|Tang, Wenbo; Kowgier, Matthew; Loth, Daan W et al. (2014) Large-scale genome-wide association studies and meta-analyses of longitudinal change in adult lung function. PLoS One 9:e100776|
|Lubitz, Steven A; Lunetta, Kathryn L; Lin, Honghuang et al. (2014) Novel genetic markers associate with atrial fibrillation risk in Europeans and Japanese. J Am Coll Cardiol 63:1200-10|
|Nalls, Mike A; Pankratz, Nathan; Lill, Christina M et al. (2014) Large-scale meta-analysis of genome-wide association data identifies six new risk loci for Parkinson's disease. Nat Genet 46:989-93|
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