instructions): The mlsslon of the Pllot and Feasibility Program at the UCSD/UCLA DRC is to foster the development of new invesfigators and provide seed support for high-risk diabetes-related research projects with an emphasis on translational science. The core is directed by Dr. Pinchas Cohen, who is also DRC Associate Director, and a member of the Nafional Diabetes Centers Directors Executive Committee. Over the last decade, the program funded 41 scienfists (28 over the last 5 years, facilitated by an ARRA supplement to the DRC for the support of P&F projects), over 90% of which have been young investigators and more that 95% of them are still active in diabetes research. These investigators garnered an impressive post-funding record of addifional NIH support and published a large amount of papers in high impact journals. These achievements underscore the exceptional pipeline of young investigators that exists in our insfitufions. Specific Objecfives for the P&F Program in this compefifive renewal applicafion are to confinue to: ?promote emerging diabetes projects and future scientific leaders;advertise, inform and engage the diabetes research communifies regarding the DRC P&F and its opportunifies;facilitate and speed transition to external funding;leverage institutional matching support, infrastructure, and technologies towards the success of P&F projects;synergize with other institutional training and research programs;create access for emerging diabetes researchers to the latest research technologies and state-of-the-art facilities and services; foster collaborative research among junior and senior scientists;promote leadership skills;and implement oversight and programmatic review of the P&F program and its awardees. We propose to fund five $50,000 grants each year to provide support for collecfing preliminary data sufficient to support ROI grant applicafions with a focus on newer invesfigators and translafional research. We have established a process of advertising, solicifing, reviewing, awarding, and (if necessary) terminafing P&F projects. This program is assisted by mulfiple experienced external reviewers. We leveraged substanfial institufional matching support from all of the institutions that comprise the DRC, to support promising proposals. Using this institutional matching support, each year, we will fund a sixth, $50,000 P&F award;and one grant per year will be identified as a """"""""junior faculty developmental award"""""""" and will receive an addifional $25,000 in year one and will also receive institufional support of $50,000 for a second year. Finally, we will support P&F awards with $10,000 of credit towards use in DRC cores. .

Public Health Relevance

Given the Strong leadership ofthe UCSD/UCLA P&F Program;the innovative ancillary programs available to the awardees, and the emphasis on supporting young investigators that have a remarkable record of success, we expect this program to enable us to substantially advance our goal of continuing our strong track record of producing independent investigators performing cutting-edge translational diabetes research. This will promote the continued advancement of diabetes care and research regionally and nationally.

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Center Core Grants (P30)
Project #
2P30DK063491-11
Application #
8443942
Study Section
Special Emphasis Panel (ZDK1-GRB-S (O2))
Project Start
Project End
Budget Start
2013-05-01
Budget End
2014-04-30
Support Year
11
Fiscal Year
2013
Total Cost
$365,413
Indirect Cost
$129,663
Name
University of California San Diego
Department
Type
DUNS #
804355790
City
La Jolla
State
CA
Country
United States
Zip Code
92093
Wang, Shuai; Zhao, Jing Hua; An, Ping et al. (2016) General Framework for Meta-Analysis of Haplotype Association Tests. Genet Epidemiol 40:244-52
Keaton, Jacob M; Hellwege, Jacklyn N; Ng, Maggie C Y et al. (2016) GENOME-WIDE INTERACTION WITH SELECTED TYPE 2 DIABETES LOCI REVEALS NOVEL LOCI FOR TYPE 2 DIABETES IN AFRICAN AMERICANS. Pac Symp Biocomput 22:242-253
Below, Jennifer E; Parra, Esteban J; Gamazon, Eric R et al. (2016) Meta-analysis of lipid-traits in Hispanics identifies novel loci, population-specific effects, and tissue-specific enrichment of eQTLs. Sci Rep 6:19429
Chung, Heekyung; Chou, Winjet; Sears, Dorothy D et al. (2016) Time-restricted feeding improves insulin resistance and hepatic steatosis in a mouse model of postmenopausal obesity. Metabolism 65:1743-1754
Tian, Xiao Yu; Ganeshan, Kirthana; Hong, Cynthia et al. (2016) Thermoneutral Housing Accelerates Metabolic Inflammation to Potentiate Atherosclerosis but Not Insulin Resistance. Cell Metab 23:165-78
Golden, Diana; Kolmakova, Antonina; Sura, Sunitha et al. (2016) Lymphocyte activation gene 3 and coronary artery disease. JCI Insight 1:e88628
Gholkar, Ankur A; Senese, Silvia; Lo, Yu-Chen et al. (2016) The X-Linked-Intellectual-Disability-Associated Ubiquitin Ligase Mid2 Interacts with Astrin and Regulates Astrin Levels to Promote Cell Division. Cell Rep 14:180-8
Larson, Nicholas B; Decker, Paul A; Wassel, Christina L et al. (2016) Blood group antigen loci demonstrate multivariate genetic associations with circulating cellular adhesion protein levels in the Multi-Ethnic Study of Atherosclerosis. Hum Genet 135:415-23
Wang, Bo; Rong, Xin; Duerr, Mark A et al. (2016) Intestinal Phospholipid Remodeling Is Required for Dietary-Lipid Uptake and Survival on a High-Fat Diet. Cell Metab 23:492-504
(2016) A principal component meta-analysis on multiple anthropometric traits identifies novel loci for body shape. Nat Commun 7:13357

Showing the most recent 10 out of 706 publications