The Administrative Core is responsible for allocation, management, and oversight of DRC resources. The Administrative Core, in coordination with the DRC Executive Committee and the two Advisory Committees (Internal and External) establishes and implements program objectives and Core utilization targets, reviews and approves membership applications, organizes the research base into coherent interest groups and facilitates communication among them, oversees program enrichment activities, and administers the P&F and enrichment programs. The Core is responsible for allocation of resources among different Cores based on workflows, user base, technical, and strategic considerations. It is also responsible for administrative oversight of personnel actions, financial management and reporting, conforming to University standards for space and resource utilization, and providing appropriate human resource management to Core Directors to implement billing and expedite technical support and personnel actions. The Core is also responsible for development, maintenance, and timely update of the DRC website. The Core ensures continuity of operations in the event of replacement of Core leadership or technical personnel, and oversees compliance with University regulations regarding human subjects, animal experimentation, technology transfer, hazardous and radioactive maternal compliance. The Administrative Core leadership represents the DRC within the faculty of the College of Physician &Surgeons, and is responsible to ensure that the DRC figures prominently in the school's strategic and programmatic goals. Dr. Domenico Accili, MD will serve as Director of the Administrative Core. In this capacity, he will oversee DRC activities, including DRC membership, administration of Core Facilities and P&F program, convene the Advisory Boards and attend ready meetings of the DRC Pis. He will be assisted by Dr. Rudolph Leibel, DRC Co-PI, Director of Core A (Genomics), and Associate Director for Pilot &Feasibility Program. Together, the Co-PIs will integrate DRC activities with institutional Centers and initiatives that can benefit diabetes research and training. They will ensure the seamless operation of DRC Core facilities and their integration with University-wide facilities (including the NY Obesity Research Center) to avoid duplication of costs and effort. In a similar vein, the Co-PIs will proactively integrate DRC activities with those of other DRCs, especially the neighboring Northeast Centers, as well as other NIDDK consortial and program activities, e.g.. Mouse Metabolic Phenotyping Centers and Beta Cell Biology Consortium.

Public Health Relevance

The Administrative Core is essential to develop the strategy of the Columbia DRC and implement its interdependent elements. It provides overall structural and organizational leadership, it ensures the proper oversight of financial and program enrichment tools, including Core Facilities, and it enables appropriate external review and oversight It integrates different elements of the program to ensure more rapid and efficient access of diabetes researchers to needed resources, encouraging collaborations.

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Center Core Grants (P30)
Project #
5P30DK063608-12
Application #
8634770
Study Section
Special Emphasis Panel (ZDK1)
Project Start
Project End
Budget Start
2014-02-01
Budget End
2015-01-31
Support Year
12
Fiscal Year
2014
Total Cost
Indirect Cost
Name
Columbia University (N.Y.)
Department
Type
DUNS #
City
New York
State
NY
Country
United States
Zip Code
10032
Kode, A; Mosialou, I; Manavalan, S J et al. (2016) FoxO1-dependent induction of acute myeloid leukemia by osteoblasts in mice. Leukemia 30:1-13
Kim-Muller, Ja Young; Kim, Young Jung R; Fan, Jason et al. (2016) FoxO1 Deacetylation Decreases Fatty Acid Oxidation in β-Cells and Sustains Insulin Secretion in Diabetes. J Biol Chem 291:10162-72
Kuo, Taiyi; Kim-Muller, Ja Young; McGraw, Timothy E et al. (2016) Altered Plasma Profile of Antioxidant Proteins as an Early Correlate of Pancreatic β Cell Dysfunction. J Biol Chem 291:9648-56
Lerea, Jaclyn S; Ring, Laurence E; Hassouna, Rim et al. (2016) Reducing Adiposity in a Critical Developmental Window Has Lasting Benefits in Mice. Endocrinology 157:666-78
Xuan, Shouhong; Sussel, Lori (2016) GATA4 and GATA6 regulate pancreatic endoderm identity through inhibition of hedgehog signaling. Development 143:780-6
Grijalva, Ambar; Xu, Xiaoyuan; Ferrante Jr, Anthony W (2016) Autophagy Is Dispensable for Macrophage-Mediated Lipid Homeostasis in Adipose Tissue. Diabetes 65:967-80
Juan De Solis, Alain; Baquero, Arian F; Bennett, Camdin M et al. (2016) Postnatal undernutrition delays a key step in the maturation of hypothalamic feeding circuits. Mol Metab 5:198-209
Madra, M; Zeltser, L M (2016) BDNF-Val66Met variant and adolescent stress interact to promote susceptibility to anorexic behavior in mice. Transl Psychiatry 6:e776
Kim-Muller, Ja Young; Fan, Jason; Kim, Young Jung R et al. (2016) Aldehyde dehydrogenase 1a3 defines a subset of failing pancreatic β cells in diabetic mice. Nat Commun 7:12631
Li, Dylan; Zhang, Feng; Zhang, Xuan et al. (2016) Distinct functions of PPARγ isoforms in regulating adipocyte plasticity. Biochem Biophys Res Commun 481:132-138

Showing the most recent 10 out of 192 publications