Abstract

The principal goal of the Human Phenotyping Core is to provide high quality, innovative and state-of-the-art clinical phenotypes for NORC members The current objectives of the Core are to: a) Complete testing and validation of the procedures currently in development. b) Consolidate and finalize quality control procedures. In addition, we plan to maintain and consolidate our current quality control procedures, and strive to provide efficient and high quality services to NORC users. A major goal of the Human Phenotyping Core is to complete QC sheets (see Appendix VIM) for each phenotype. c) Develop fMRI - the major initiative of the Human Phenotyping Sub-Core in the next cycle will be to develop and validate functional Magnetic Resonance Imaging (fMRI) procedures. Dr. Steven Smith will devote 10 % of his time to this task and transition it to Dr. Ravussin and an Investigator with Physics Science expertise to be named.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Center Core Grants (P30)
Project #
5P30DK072476-09
Application #
8565075
Study Section
Special Emphasis Panel (ZDK1-GRB-2)
Project Start
Project End
Budget Start
2013-09-01
Budget End
2014-08-31
Support Year
9
Fiscal Year
2013
Total Cost
$228,783
Indirect Cost
$74,200

  Institution

Name
Lsu Pennington Biomedical Research Center
Department
Type
DUNS #
611012324
City
Baton Rouge
State
LA
Country
United States
Zip Code
70808

  Publications

Clark, Richard V; Walker, Ann C; Miller, Ram R et al. (2018) Creatine ( methyl-d3) dilution in urine for estimation of total body skeletal muscle mass: accuracy and variability vs. MRI and DXA. J Appl Physiol (1985) 124:1-9
Graf, Brittany L; Zhang, Li; Corradini, Maria G et al. (2018) Physicochemical differences between malanga (Xanthosoma sagittifolium) and potato (Solanum tuberosum) tubers are associated with differential effects on the gut microbiome. J Funct Foods 45:268-276
White, Ursula A; Fitch, Mark D; Beyl, Robbie A et al. (2018) Racial differences in in vivo adipose lipid kinetics in humans. J Lipid Res 59:1738-1744
Most, Jasper; Gilmore, L Anne; Altazan, Abby D et al. (2018) Propensity for adverse pregnancy outcomes in African-American women may be explained by low energy expenditure in early pregnancy. Am J Clin Nutr 107:957-964
Thomas-Porch, Caasy; Li, Jie; Zanata, Fabiana et al. (2018) Comparative proteomic analyses of human adipose extracellular matrices decellularized using alternative procedures. J Biomed Mater Res A 106:2481-2493
Stephens, Jacqueline M; Bailey, Jennifer L; Hang, Hardy et al. (2018) Adipose Tissue Dysfunction Occurs Independently of Obesity in Adipocyte-Specific Oncostatin Receptor Knockout Mice. Obesity (Silver Spring) 26:1439-1447
Forney, Laura A; Stone, Kirsten P; Wanders, Desiree et al. (2018) Sensing and signaling mechanisms linking dietary methionine restriction to the behavioral and physiological components of the response. Front Neuroendocrinol 51:36-45
Able, Ashley Ann; Richard, Allison J; Stephens, Jm (2018) Loss of DBC1 (CCAR2) affects TNF?-induced lipolysis and Glut4 gene expression in murine adipocytes. J Mol Endocrinol 61:195-205
Costford, Sheila R; Brouwers, Bram; Hopf, Meghan E et al. (2018) Skeletal muscle overexpression of nicotinamide phosphoribosyl transferase in mice coupled with voluntary exercise augments exercise endurance. Mol Metab 7:1-11
Most, Jasper; Vallo, Porsha M; Gilmore, L Anne et al. (2018) Energy Expenditure in Pregnant Women with Obesity Does Not Support Energy Intake Recommendations. Obesity (Silver Spring) 26:992-999

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