The Administrative Core oversees all functions of the DHC, including membership, delivery of Core Services, the Enrichment Program, monitoring of the scientific output of Center investigators, administration of the Pilot and Feasibility Program, and budget. The day-to-day operation is the responsibility of the Center Director (Dr. Jorge Bezerra) and of the Project Manager (Dr. Cynthia Wetzel). The Director, Project Manager, and the Associate Directors [Drs. Mitchell Cohen, Marshall (Chip) Montrose, and Aaron Zorn] form the Leadership Committee and meet every Thursday to review any issues related to Core utilization and progress in major functions of the Center (Enrichment Program, Pilot and Feasibility Program, Clinical Component). This weekly meeting, which was implemented at the start of the DHC four years ago, greatly facilitates communication among the leadership and enables the Project Manager to respond to the needs of the DHC membership in a timely fashion. The primary appointment of two investigators from outside the GI Division Dr. Montrose (Cell Physiology, University of Cincinnati College of Medicine-UCCOM) and Dr. Zorn (Development Biology, Cincinnati Children's Hospital Medical Center-CCHMC), further enhances the exchange of knowledge within the leadership of programmatic initiatives taking place in the Academic Health Center (CCHMC and UCCOM), thus enabling the DHC leadership to take advantage of these initiatives to create opportunities to better serve the DHC membership and the field of digestive disease research. The Leadership Committee is the main component of the Administrative Core;its relationship to the Internal and External Advisory Boards, CCHMC and the Academic Health Center will be presented later in this section.

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Center Core Grants (P30)
Project #
5P30DK078392-08
Application #
8665910
Study Section
Special Emphasis Panel (ZDK1)
Project Start
Project End
Budget Start
2014-06-01
Budget End
2015-05-31
Support Year
8
Fiscal Year
2014
Total Cost
Indirect Cost
City
Cincinnati
State
OH
Country
United States
Zip Code
45229
Bezerra, Jorge A (2016) MDR3 mutation analysis: A step closer to precision medicine. Hepatology 63:1421-3
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D'Mello, R J; Caldwell, J M; Azouz, N P et al. (2016) LRRC31 is induced by IL-13 and regulates kallikrein expression and barrier function in the esophageal epithelium. Mucosal Immunol 9:744-56
Giles, Daniel A; Moreno-Fernandez, Maria E; Stankiewicz, Traci E et al. (2016) Regulation of Inflammation by IL-17A and IL-17F Modulates Non-Alcoholic Fatty Liver Disease Pathogenesis. PLoS One 11:e0149783
Goldschmidt, Monique L; Mourya, Reena; Connor, Jessica et al. (2016) Increased frequency of double and triple heterozygous gene variants in children with intrahepatic cholestasis. Hepatol Res 46:306-11
Fecher, Roger A; Horwath, Michael C; Friedrich, Dirk et al. (2016) Inverse Correlation between IL-10 and HIF-1α in Macrophages Infected with Histoplasma capsulatum. J Immunol 197:565-79
Davis, Benjamin P; Stucke, Emily M; Khorki, M Eyad et al. (2016) Eosinophilic esophagitis-linked calpain 14 is an IL-13-induced protease that mediates esophageal epithelial barrier impairment. JCI Insight 1:e86355
Giles, Daniel A; Ramkhelawon, Bhama; Donelan, Elizabeth M et al. (2016) Modulation of ambient temperature promotes inflammation and initiates atherosclerosis in wild type C57BL/6 mice. Mol Metab 5:1121-1130
Goodson, M L; Packard, A E B; Buesing, D R et al. (2016) Chronic stress and Rosiglitazone increase indices of vascular stiffness in male rats. Physiol Behav :

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