The O'Brien Center for Advanced Renal Microscopic Analysis will provide the resources and expertise necessary to apply structural and functional imaging technologies to further the understanding of renal physiology, disease processes and their therapy as a Regional, National and International Core facility. The Administrative Core will provide scientifically rigorous, state-of-the-art methodologies in a cost-effective manner to foster Investigations;coordinate and integrate diverse activities of all elements of the O'Brien Center, facilitate interactions and collaborations among the research base, ensure quality control of the core services;oversee the O'Brien Fellows Program;and organize and support the educational enrichment program to serve all investigators.

Public Health Relevance

The Administrative Core will enable optimal coordination and performance of the various Core Center components that will advance the science and technology of multiphoton Imaging to enhance understanding of kidney diseases and their therapy.

National Institute of Health (NIH)
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Center Core Grants (P30)
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Special Emphasis Panel (ZDK1-GRB-6)
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Indiana University-Purdue University at Indianapolis
United States
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Day, Richard N (2014) Measuring protein interactions using Forster resonance energy transfer and fluorescence lifetime imaging microscopy. Methods 66:200-7
Hall, Andrew M; Molitoris, Bruce A (2014) Dynamic multiphoton microscopy: focusing light on acute kidney injury. Physiology (Bethesda) 29:334-42
Kapitsinou, Pinelopi P; Sano, Hideto; Michael, Mark et al. (2014) Endothelial HIF-2 mediates protection and recovery from ischemic kidney injury. J Clin Invest 124:2396-409
Dickson, Landon E; Wagner, Mark C; Sandoval, Ruben M et al. (2014) The proximal tubule and albuminuria: really! J Am Soc Nephrol 25:443-53
Sandoval, Ruben M; Wang, Exing; Molitoris, Bruce A (2014) Finding the bottom and using it: Offsets and sensitivity in the detection of low intensity values in vivo with 2-photon microscopy. Intravital 2:
Sandoval, Ruben M; Molitoris, Bruce A (2013) Quantifying glomerular permeability of fluorescent macromolecules using 2-photon microscopy in Munich Wistar rats. J Vis Exp :
Shaner, Nathan C; Lambert, Gerard G; Chammas, Andrew et al. (2013) A bright monomeric green fluorescent protein derived from Branchiostoma lanceolatum. Nat Methods 10:407-9
Werner, Michael E; Ward, Heather H; Phillips, Carrie L et al. (2013) Inversin modulates the cortical actin network during mitosis. Am J Physiol Cell Physiol 305:C36-47
Blaeser, Anthony; Keramaris, Elizabeth; Chan, Yiumo M et al. (2013) Mouse models of fukutin-related protein mutations show a wide range of disease phenotypes. Hum Genet 132:923-34
Hato, Takashi; El-Achkar, Tarek M; Dagher, Pierre C (2013) Sisters in arms: myeloid and tubular epithelial cells shape renal innate immunity. Am J Physiol Renal Physiol 304:F1243-51

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