The University of Alabama at Birmingham (UAB)-University of California at San Diego (UCSD) O'Brien Core Center for Acute Kidney Injury (AKI) is designed to provide scientifically rigorous, state-of-the-art methodologies in a cost-effective manner to foster investigations that will (i) advance our understanding of the pathophysiology of AKI, (ii) enhance our diagnostic specificity and (iii) expand our therapeutic approaches for patients with AKI. The administrative core will coordinate and integrate the diverse activities of the UAB-UCSD O'Brien center, facilitate interactions and collaborations among the research base, ensure quality control of the core services and promote scientific development. The administrative core includes a Biostatistical Resource (BR), which will provide statistical support for the cores and research and pilot projects of the O'Brien Center. The administrative structure with clear lines of authority has been developed to ensure that the goals and objectives of the center are achieved. The Director and Associate Directors will be advised by an Internal Advisory Committee, who were carefully selected based on their experience in directing high quality large research programs and include the Directors of the Clinical and Translational Science Awards (CTSA) at both UAB and UCSD. In addition, the Center leadership will be advised by an External Advisory Committee, a Pilot and Feasibility (PAF) Program Committee and a Scientific Advisory Committee for each Core. The Administrative Core will continue to oversee the PAF Program and will be responsible for evaluating the Pilot Program's efficacy in promoting high quality AKI-related research that leads to extramural funding and publications. In addition, the Administrative Core will organize and support an enrichment program consisting of seminars with visiting speakers, journal clubs/work-in progress sessions, interface with CTSA enrichment programs. Summer Student's Training Program, and an Annual Comprehensive Research Symposium. The Administrative Core has also established a communication network through email, newsletters, live video conferencing and a website to inform Core Center investigators of the center activities and funding opportunities, AKI-related news, as well as the availability of new reagents and technologies through the Center. Therefore, the Administrative Core will enable optimal coordination of the various Core Center components through its committees, regularly scheduled meetings, seminar series, web-based communication mechanisms and video conferences between participating institutions.

Public Health Relevance

The administrative component will assure the effective application of the UAB-UCSD O'Brien Center resources to promote excellence in Acute kidney injury (AKI) research and an outstanding environment for training and enrichment. Through these efforts, the Center will advance knowledge that will lead to better outcomes and improve the health and well being of patients with AKI.

National Institute of Health (NIH)
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Center Core Grants (P30)
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Special Emphasis Panel (ZDK1-GRB-6 (M2))
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University of Alabama Birmingham
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Fu, Yiling; Gerasimova, Maria; Batz, Falk et al. (2015) PPAR? agonist-induced fluid retention depends on ?ENaC expression in connecting tubules. Nephron 129:68-74
Murray, Patrick T; Mehta, Ravindra L; Shaw, Andrew et al. (2014) Potential use of biomarkers in acute kidney injury: report and summary of recommendations from the 10th Acute Dialysis Quality Initiative consensus conference. Kidney Int 85:513-21
Wetta, Luisa A; Biggio, Joseph R; Cliver, Suzanne et al. (2014) Is midtrimester vitamin D status associated with spontaneous preterm birth and preeclampsia? Am J Perinatol 31:541-6
Wall, Stephanie B; Smith, M Ryan; Ricart, Karina et al. (2014) Detection of electrophile-sensitive proteins. Biochim Biophys Acta 1840:913-22
Virk-Baker, Mandeep K; Barnes, Stephen; Krontiras, Helen et al. (2014) S-(-)equol producing status not associated with breast cancer risk among low isoflavone-consuming US postmenopausal women undergoing a physician-recommended breast biopsy. Nutr Res 34:116-25
Andringa, Kelly K; Agarwal, Anupam (2014) Role of hypoxia-inducible factors in acute kidney injury. Nephron Clin Pract 127:70-4
Portilla, Didier (2014) Apoptosis, fibrosis and senescence. Nephron Clin Pract 127:65-9
Nourbakhsh, Noureddin; Singh, Prabhleen (2014) Role of renal oxygenation and mitochondrial function in the pathophysiology of acute kidney injury. Nephron Clin Pract 127:149-52
Kumar, Rajiv; Vallon, Volker (2014) Reduced renal calcium excretion in the absence of sclerostin expression: evidence for a novel calcium-regulating bone kidney axis. J Am Soc Nephrol 25:2159-68
Abdul Roda, Mojtaba; Sadik, Mariam; Gaggar, Amit et al. (2014) Targeting prolyl endopeptidase with valproic acid as a potential modulator of neutrophilic inflammation. PLoS One 9:e97594

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