This proposal will continue the progress of the DRTC, first established at UAB in 2008, and the transition to a DRC. The immediate goal of the center is to promote excellence in diabetes research. Over the past 4 years, the DRC has galvanized the UAB research community around the study of diabetes resulting in an increase in membership from 115 to 159, and a 32.5% increase in extramural research funding. Through these efforts, the center ultimately endeavors to decrease diabetes morbidity/mortality, and to provide an outstanding environment for training and career development in diabetes research.
Our specific aims are to: 1. Facilitate and enhance diabetes research by sponsoring research core facilities expressly required by our investigator base. The five research cores cover a broad translational spectrum: Bioanalytical REDOX Biology, Islet Cell Biology, Animal Physiology, Human Biology, and Interventions &Translation Cores. 2. Augment diabetes research via a pilot &feasibility grant program that will emphasize innovation, translation, and career development of highly promising junior investigators. 3. Sponsor an integrated Enrichment Program that promotes a cohesive environment for an outstanding multi-disciplinary investigator base, which will enhance learning, collaboration, collegiality, and innovation. 4. Build upon the progress achieved over our first 4 years by responding to the evolving needs of our investigators and through leadership that impels new ideas and lines of investigation. 5. Emphasize research, training, and outreach that are responsive to the needs of our trainees, achieve better outcomes for our patients, and lessen the high burden of diabetes in our community and nation. 6. Leverage the resolve of UAB leadership, substantial institutional commitments, and generous philanthropy from our community to further impel the development of a pre-eminent center of diabetes research excellence in the heart of the Deep South. Our DRC is located in a community with the highest rates of diabetes in the US, and unites investigators around common themes to study diabetes in the context of cardiometabolic disease.

Public Health Relevance

The UAB DRC is the only NIDDK diabetes center located in the Deep South, at the 'Diabetes Belt'epicenter characterized by the highest rates of diabetes in the US. The Center has developed a comprehensive strategy for new discoveries and a strong environment for training the next generation of research leaders. Thus, the UAB DRC endeavors to lessen the burden of patient suffering and high social costs of diabetes.

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Center Core Grants (P30)
Project #
2P30DK079626-06
Application #
8436584
Study Section
Special Emphasis Panel (ZDK1-GRB-S (O2))
Program Officer
Hyde, James F
Project Start
2008-04-01
Project End
2018-02-28
Budget Start
2013-03-01
Budget End
2014-02-28
Support Year
6
Fiscal Year
2013
Total Cost
$1,133,433
Indirect Cost
$343,888
Name
University of Alabama Birmingham
Department
Nutrition
Type
Schools of Allied Health Profes
DUNS #
063690705
City
Birmingham
State
AL
Country
United States
Zip Code
35294
Goldsby, TaShauna U; George, Brandon J; Yeager, Valerie A et al. (2016) Urban Park Development and Pediatric Obesity Rates: A Quasi-Experiment Using Electronic Health Record Data. Int J Environ Res Public Health 13:411
Hong, Kyunghee; Xu, Guanlan; Grayson, Truman B et al. (2016) Cytokines Regulate β-Cell Thioredoxin-interacting Protein (TXNIP) via Distinct Mechanisms and Pathways. J Biol Chem 291:8428-39
Jones, Kristian T; Shelton, Richard C; Wan, Jun et al. (2016) Impact of acute psychological stress on cardiovascular risk factors in face of insulin resistance. Stress 19:585-592
Wende, Adam R; Young, Martin E; Chatham, John et al. (2016) Redox biology and the interface between bioenergetics, autophagy and circadian control of metabolism. Free Radic Biol Med 100:94-107
Cunningham, Glenn R; Stephens-Shields, Alisa J; Rosen, Raymond C et al. (2016) Testosterone Treatment and Sexual Function in Older Men With Low Testosterone Levels. J Clin Endocrinol Metab 101:3096-104
Cardel, M I; Johnson, S L; Beck, J et al. (2016) The effects of experimentally manipulated social status on acute eating behavior: A randomized, crossover pilot study. Physiol Behav 162:93-101
Krzywanski, David M; Moellering, Douglas R; Westbrook, David G et al. (2016) Endothelial Cell Bioenergetics and Mitochondrial DNA Damage Differ in Humans Having African or West Eurasian Maternal Ancestry. Circ Cardiovasc Genet 9:26-36
Howard, George; Moy, Claudia S; Howard, Virginia J et al. (2016) Where to Focus Efforts to Reduce the Black-White Disparity in Stroke Mortality: Incidence Versus Case Fatality? Stroke 47:1893-8
Sweatt, S Katherine; Roy, Jane; Chandler-Laney, Paula et al. (2016) Ethnic differences in the consistency and accuracy of perceived exertion. Am J Hum Biol 28:398-404
Deng, Ke-Qiong; Wang, Aibing; Ji, Yan-Xiao et al. (2016) Suppressor of IKKÉ› is an essential negative regulator of pathological cardiac hypertrophy. Nat Commun 7:11432

Showing the most recent 10 out of 481 publications