The Human Physiology Core has had a remarkable record of productivity with increasing provision of services over the first 4 years of the DRTC. The broad, long-range objectives and goals as a DRC Core are to: ? Provide analysis of hormones, adipokines, markers of inflammation, glucose, lipids, and molecules relevant to diabetes risk and pathophysiology for both clinical and animal studies, and from both biological fluids and tissue culture specimens. Provide assessment of human insulin sensitivity, beta-cell function, and in vivo glucose metabolism. The Core provides assistance with the euglycemic clamp, the intravenous glucose tolerance test, the mixed macronutrient meal test, and the oral glucose tolerance test. Core personnel assist with drafting and implementing test protocols, and provide sample analysis, data reduction, mathematical modeling, and help with interpretation of results. ? Provide assessment of human body composition as related to diabetes risk. The Core supports measueres of visceral and subcutaneous abdominal adipose tissue, intermuscular adipose tissue, intrahepatic lipid, intramyocellular lipid, and bone marrow adipose tissue. Core peronnel assist with protocol implementation using MRI, MRS, and CT, and provide analysis of relevant tissue measures using SliceOmatic and other software as appropriate. Bone and muscle composition and density also are assessed with MRI and pQCT. The Core is equipped to assess every element of the "bone-fat-pancreas" axis to advance research regarding the concept that bone metabolism affects diabetes risk. Provide assessment of cardiovascular function, including endothelial function, arterial compliance, thoracic impedance, and ambulatory blood pressure. Provide cost-effective, centralized services to ongoing funded and pilot research projects. Promote multi-disciplinary research and training in diabetes across the UAB campus. Offer training, advice, and instruction to graduate students, fellows, and investigators.

Public Health Relevance

The Human Physiology Core provides important tools for translational research related to human metabolism in the DRC. This includes assays and technologies pertaining to glucose homeostasis, insulin sensitivity, beta-cell function, and adipose tissue distribution. The Core stays abreast of developments in diabetes research technology, and responds to investigator needs by adding necessary tests and measures. The Core provides training to UAB invfistioators. and promotes interdiscinlinarv diabfites-related research.

National Institute of Health (NIH)
Center Core Grants (P30)
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Special Emphasis Panel (ZDK1)
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University of Alabama Birmingham
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Misra, Devyani; Felson, David T; Silliman, Rebecca A et al. (2015) Knee osteoarthritis and frailty: findings from the Multicenter Osteoarthritis Study and Osteoarthritis Initiative. J Gerontol A Biol Sci Med Sci 70:339-44
Panwar, Bhupesh; Hanks, Lynae J; Tanner, Rikki M et al. (2015) Obesity, metabolic health, and the risk of end-stage renal disease. Kidney Int 87:1216-22
Casazza, Krista; Brown, Andrew; Astrup, Arne et al. (2015) Weighing the Evidence of Common Beliefs in Obesity Research. Crit Rev Food Sci Nutr 55:2014-53
Harper, Lorie M; Tita, Alan; Biggio, Joseph R (2015) The institute of medicine guidelines for gestational weight gain after a diagnosis of gestational diabetes and pregnancy outcomes. Am J Perinatol 32:239-46
Cree-Green, Melanie; Newcomer, Bradley R; Brown, Mark S et al. (2015) Delayed skeletal muscle mitochondrial ADP recovery in youth with type 1 diabetes relates to muscle insulin resistance. Diabetes 64:383-92
Bone, Robert N; Gai, Ying; Magrioti, Victoria et al. (2015) Inhibition of Ca2+-independent phospholipase A2? (iPLA2?) ameliorates islet infiltration and incidence of diabetes in NOD mice. Diabetes 64:541-54
Carson, April P; Steffes, Michael W; Carr, J Jeffrey et al. (2015) Hemoglobin a1c and the progression of coronary artery calcification among adults without diabetes. Diabetes Care 38:66-71
Clement, Lionel C; Macé, Camille; Del Nogal Avila, Maria et al. (2015) The proteinuria-hypertriglyceridemia connection as a basis for novel therapeutics for nephrotic syndrome. Transl Res 165:499-504
Hanks, Lynae J; Casazza, Krista; Ashraf, Ambika P et al. (2015) Fibroblast growth factor-21, body composition, and insulin resistance in pre-pubertal and early pubertal males and females. Clin Endocrinol (Oxf) 82:550-6
Shen, Ming-Che; Zhao, Xiangmin; Siegal, Gene P et al. (2014) Dietary stearic acid leads to a reduction of visceral adipose tissue in athymic nude mice. PLoS One 9:e104083

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