The Human Physiology Core has had a remarkable record of productivity with increasing provision of services over the first 4 years of the DRTC. The broad, long-range objectives and goals as a DRC Core are to: ? Provide analysis of hormones, adipokines, markers of inflammation, glucose, lipids, and molecules relevant to diabetes risk and pathophysiology for both clinical and animal studies, and from both biological fluids and tissue culture specimens. Provide assessment of human insulin sensitivity, beta-cell function, and in vivo glucose metabolism. The Core provides assistance with the euglycemic clamp, the intravenous glucose tolerance test, the mixed macronutrient meal test, and the oral glucose tolerance test. Core personnel assist with drafting and implementing test protocols, and provide sample analysis, data reduction, mathematical modeling, and help with interpretation of results. ? Provide assessment of human body composition as related to diabetes risk. The Core supports measueres of visceral and subcutaneous abdominal adipose tissue, intermuscular adipose tissue, intrahepatic lipid, intramyocellular lipid, and bone marrow adipose tissue. Core peronnel assist with protocol implementation using MRI, MRS, and CT, and provide analysis of relevant tissue measures using SliceOmatic and other software as appropriate. Bone and muscle composition and density also are assessed with MRI and pQCT. The Core is equipped to assess every element of the bone-fat-pancreas axis to advance research regarding the concept that bone metabolism affects diabetes risk. Provide assessment of cardiovascular function, including endothelial function, arterial compliance, thoracic impedance, and ambulatory blood pressure. Provide cost-effective, centralized services to ongoing funded and pilot research projects. Promote multi-disciplinary research and training in diabetes across the UAB campus. Offer training, advice, and instruction to graduate students, fellows, and investigators.

Public Health Relevance

The Human Physiology Core provides important tools for translational research related to human metabolism in the DRC. This includes assays and technologies pertaining to glucose homeostasis, insulin sensitivity, beta-cell function, and adipose tissue distribution. The Core stays abreast of developments in diabetes research technology, and responds to investigator needs by adding necessary tests and measures. The Core provides training to UAB invfistioators. and promotes interdiscinlinarv diabfites-related research.

National Institute of Health (NIH)
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Center Core Grants (P30)
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Special Emphasis Panel (ZDK1-GRB-S)
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University of Alabama Birmingham
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Birur, Badari; Shelton, Richard C; Amrock, Ellen M et al. (2017) Response to: Commentary: Sex Differences in the Peripheral Immune System in Patients with Depression. Front Psychiatry 8:231
Akinyemiju, Tomi; Ogunsina, Kemi; Okwali, Michelle et al. (2017) Lifecourse socioeconomic status and cancer-related risk factors: Analysis of the WHO study on global ageing and adult health (SAGE). Int J Cancer 140:777-787
Li, Li; Garvey, W Timothy; Gower, Barbara A (2017) Childhood Maltreatment Is an Independent Risk Factor for Prediabetic Disturbances in Glucose Regulation. Front Endocrinol (Lausanne) 8:151
Carter, Stephen J; Plaisance, Eric P; Fisher, Gordon et al. (2017) Alterations in Hemoglobin and Serum 25-hydroxyvitamin D are Related Before and After Weight Loss Independent of African Admixture. Int J Sport Nutr Exerc Metab 27:59-66
Budoff, Matthew J; Ellenberg, Susan S; Lewis, Cora E et al. (2017) Testosterone Treatment and Coronary Artery Plaque Volume in Older Men With Low Testosterone. JAMA 317:708-716
Prigge, Justin R; Coppo, Lucia; Martin, Sebastin S et al. (2017) Hepatocyte Hyperproliferation upon Liver-Specific Co-disruption of Thioredoxin-1, Thioredoxin Reductase-1, and Glutathione Reductase. Cell Rep 19:2771-2781
Piccinini, Francesca; Polidori, David C; Gower, Barbara A et al. (2017) Hepatic but Not Extrahepatic Insulin Clearance Is Lower in African American Than in European American Women. Diabetes 66:2564-2570
Resnick, Susan M; Matsumoto, Alvin M; Stephens-Shields, Alisa J et al. (2017) Testosterone Treatment and Cognitive Function in Older Men With Low Testosterone and Age-Associated Memory Impairment. JAMA 317:717-727
Barbour, S E; Ramanadham, S (2017) Analyses of Calcium-Independent Phospholipase A2beta (iPLA2?) in Biological Systems. Methods Enzymol 583:119-141
Warren, Jonathan L; Bulur, Sule; Ovalle, Fernando et al. (2017) Effects of acute hyperinsulinemia on skeletal muscle mitochondrial function, reactive oxygen species production, and metabolism in premenopausal women. Metabolism 77:1-12

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