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The DDBTRCC Imaging Core provides advanced Imaging (confocal and two-photon microscopy with FRAP, FRET, TIRF) and routine imaging (fluorescence of polarized epithelial and symmetric cells studied at the single cell or whole organ level by fluorometer or microscopy based systems in which access to apical and basolateral surface can be accomplished) plus EM to our Research Base to allow characterization of the structural aspects of their projects.

National Institute of Health (NIH)
Center Core Grants (P30)
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Special Emphasis Panel (ZDK1)
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Johns Hopkins University
United States
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Llosa, Nicolas J; Cruise, Michael; Tam, Ada et al. (2015) The vigorous immune microenvironment of microsatellite instable colon cancer is balanced by multiple counter-inhibitory checkpoints. Cancer Discov 5:43-51
Cha, Boyoung; Chen, Tiane; Sarker, Rafiquel et al. (2014) Lysophosphatidic acid stimulation of NHE3 exocytosis in polarized epithelial cells occurs with release from NHERF2 via ERK-PLC-PKC? signaling. Am J Physiol Cell Physiol 307:C55-65
Gabelli, Sandra B; Boto, Agedi; Kuhns, Victoria Halperin et al. (2014) Regulation of the NaV1.5 cytoplasmic domain by calmodulin. Nat Commun 5:5126
Miller, Michelle S; Schmidt-Kittler, Oleg; Bolduc, David M et al. (2014) Structural basis of nSH2 regulation and lipid binding in PI3K?. Oncotarget 5:5198-208
Yang, Jianbo; Singh, Varsha; Chen, Tian-E et al. (2014) NHERF2/NHERF3 protein heterodimerization and macrocomplex formation are required for the inhibition of NHE3 activity by carbachol. J Biol Chem 289:20039-53
Singh, Varsha; Yang, Jianbo; Chen, Tiane-e et al. (2014) Translating molecular physiology of intestinal transport into pharmacologic treatment of diarrhea: stimulation of Na+ absorption. Clin Gastroenterol Hepatol 12:27-31
Singh, Varsha; Lin, Rong; Yang, Jianbo et al. (2014) AKT and GSK-3 are necessary for direct ezrin binding to NHE3 as part of a C-terminal stimulatory complex: role of a novel Ser-rich NHE3 C-terminal motif in NHE3 activity and trafficking. J Biol Chem 289:5449-61
Chen, Tiane; Hubbard, Ann; Murtazina, Rakhilya et al. (2014) Myosin VI mediates the movement of NHE3 down the microvillus in intestinal epithelial cells. J Cell Sci 127:3535-45
Foulke-Abel, Jennifer; In, Julie; Kovbasnjuk, Olga et al. (2014) Human enteroids as an ex-vivo model of host-pathogen interactions in the gastrointestinal tract. Exp Biol Med (Maywood) 239:1124-34
Herbrich, Shelley M; Cole, Robert N; West Jr, Keith P et al. (2013) Statistical inference from multiple iTRAQ experiments without using common reference standards. J Proteome Res 12:594-604

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