The goal of the MNORC is to support, facilitate, enhance and guide Research Base investigators in their quest for important new information related to nutrition, obesity and related metabolic disorders. In order to support an integrative, 'team science'approach to biomedical research, the breadth of scientific talent that needs to be attracted to a Center, such as the MNORC, will necessarily need expansion. Since the inception of the Michigan Metabolomics and Obesity Center (MMOC) in 2006, a focus has been on attracting the interest of a broad range of scientists, not only those who have a focused interest in nutrition and obesity, but also those investigators who have skills in complementary areas, who can bring their considerable talents to the study of nutrition and obesity. These latter scientists have brought new thinking in metabolomics, microfluidics, imaging, cognitive sciences and informatics that have enriched seminars, symposia, retreats and, most importantly, research programs. The MNORC leadership is committed to an inclusive policy to expand the thinking of investigators and further scientific team building.

Public Health Relevance

Obesity has become a national problem that has defied easy treatment. The Michigan Nutrition Obesity Research Center will provide researchers the opportunity to utilize advanced technologies and computational tools to understand how causes of obesity vary among individuals and across the population. Through these efforts, health professionals will be able to translate these lessons to the design and implementation of novel dietary, exercise and medication interventions to control obesity and obesity-related diseases.

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Center Core Grants (P30)
Project #
5P30DK089503-04
Application #
8490366
Study Section
Special Emphasis Panel (ZDK1-GRB-2 (M2))
Program Officer
Evans, Mary
Project Start
2010-07-01
Project End
2015-06-30
Budget Start
2013-07-01
Budget End
2014-06-30
Support Year
4
Fiscal Year
2013
Total Cost
$1,097,935
Indirect Cost
$391,868
Name
University of Michigan Ann Arbor
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
073133571
City
Ann Arbor
State
MI
Country
United States
Zip Code
48109
Weinhouse, Caren; Sartor, Maureen A; Faulk, Christopher et al. (2016) Epigenome-wide DNA methylation analysis implicates neuronal and inflammatory signaling pathways in adult murine hepatic tumorigenesis following perinatal exposure to bisphenol A. Environ Mol Mutagen 57:435-46
Stromsdorfer, Kelly L; Yamaguchi, Shintaro; Yoon, Myeong Jin et al. (2016) NAMPT-Mediated NAD(+) Biosynthesis in Adipocytes Regulates Adipose Tissue Function and Multi-organ Insulin Sensitivity in Mice. Cell Rep 16:1851-60
Eswaran, Shanti L; Chey, William D; Han-Markey, Theresa et al. (2016) A Randomized Controlled Trial Comparing the Low FODMAP Diet vs. Modified NICE Guidelines in US Adults with IBS-D. Am J Gastroenterol 111:1824-1832
Sondhi, Varun; Owen, Bryn M; Liu, Jiayan et al. (2016) Impaired 17,20-Lyase Activity in Male Mice Lacking Cytochrome b5 in Leydig Cells. Mol Endocrinol 30:469-78
Sidahmed, ElKhansa; Sen, Ananda; Ren, Jianwei et al. (2016) Colonic Saturated Fatty Acid Concentrations and Expression of COX-1, but not Diet, Predict Prostaglandin E2 in Normal Human Colon Tissue. Nutr Cancer 68:1192-201
Sas, Kelli M; Kayampilly, Pradeep; Byun, Jaeman et al. (2016) Tissue-specific metabolic reprogramming drives nutrient flux in diabetic complications. JCI Insight 1:e86976
Chhabra, Kavaljit H; Adams, Jessica M; Jones, Graham L et al. (2016) Reprogramming the body weight set point by a reciprocal interaction of hypothalamic leptin sensitivity and Pomc gene expression reverts extreme obesity. Mol Metab 5:869-81
Morris, David L; Oatmen, Kelsie E; Mergian, Taleen A et al. (2016) CD40 promotes MHC class II expression on adipose tissue macrophages and regulates adipose tissue CD4+ T cells with obesity. J Leukoc Biol 99:1107-19
Shaeib, Faten; Khan, Sana N; Thakur, Mili et al. (2016) The Impact of Myeloperoxidase and Activated Macrophages on Metaphase II Mouse Oocyte Quality. PLoS One 11:e0151160
Greenwald-Yarnell, Megan L; Marsh, Courtney; Allison, Margaret B et al. (2016) ERα in Tac2 Neurons Regulates Puberty Onset in Female Mice. Endocrinology 157:1555-65

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