Integrative Biostatistics and Informatics Core The Integrative Biostatistics and Informatics Core (IBIC) will provide expertise in experimental design, data management and analysis for preclinical, clinical and translational research studies conducted by MNORC Research Base investigators. The Center will continue important interactions with the Center for Computational Medicine and Bioinformatics (CCMB), the National Center for Integrative Biomedical Informatics (NCIBl), the Michigan Institute for Clinical and Health Research (MICHR) and the Biometrics and Outcomes Research Core (BORC) to provide these services. The Core will support database design for both preclinical and clinical studies. Clinically relevant databases will be Health Insurance Portability and Accountability Act (THIPAAJ compliant. The Core will also provide expertise and tools for data mining of relevant databases as well as assistance and training in the use of various tools for analysis of genomic, transcriptomic, metabolomic and proteomic data. Available tools will allow the integration and analysis of data in temporally or in relationship to phenotypic parameters collected as part of clinical studies. Finally, IBIC personnel will collaborate with ether Cores and the Investigational Weight Management Clinic to develop appropriate data formats and database constructs to integrate clinical, molecular, neurobehavioral and other phenotypic data into formats that ease analysis by biostatistical and informatics methodologies.

Public Health Relevance

The Integrative Biostatistics and Informatics Core will help design and analyze animal and human studies that utilize modern technologies aimed at understanding the causes of obesity and obesity-related diseases. The information gained from these studies may lead to new insights that will provide ways in which obesity or obesity-related diseases can be prevented or treated.

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Center Core Grants (P30)
Project #
5P30DK089503-04
Application #
8490373
Study Section
Special Emphasis Panel (ZDK1-GRB-2)
Project Start
Project End
Budget Start
2013-07-01
Budget End
2014-06-30
Support Year
4
Fiscal Year
2013
Total Cost
$159,372
Indirect Cost
$56,882
Name
University of Michigan Ann Arbor
Department
Type
DUNS #
073133571
City
Ann Arbor
State
MI
Country
United States
Zip Code
48109
Chen, Zhimin; Wang, Guo-Xiao; Ma, Sara L et al. (2017) Nrg4 promotes fuel oxidation and a healthy adipokine profile to ameliorate diet-induced metabolic disorders. Mol Metab 6:863-872
Li, Siming; Mi, Lin; Yu, Lei et al. (2017) Zbtb7b engages the long noncoding RNA Blnc1 to drive brown and beige fat development and thermogenesis. Proc Natl Acad Sci U S A 114:E7111-E7120
Schrepf, Andrew; Harte, Steven E; Miller, Nicole et al. (2017) Improvement in the Spatial Distribution of Pain, Somatic Symptoms, and Depression After a Weight Loss Intervention. J Pain 18:1542-1550
Garcia-Galiano, David; Borges, Beatriz C; Donato Jr, Jose et al. (2017) PI3K? inactivation in leptin receptor cells increases leptin sensitivity but disrupts growth and reproduction. JCI Insight 2:
Ajluni, Nevin; Meral, Rasimcan; Neidert, Adam H et al. (2017) Spectrum of disease associated with partial lipodystrophy: lessons from a trial cohort. Clin Endocrinol (Oxf) 86:698-707
Djuric, Zora; Bassis, Christine M; Plegue, Melissa A et al. (2017) Colonic Mucosal Bacteria Are Associated with Inter-Individual Variability in Serum Carotenoid Concentrations. J Acad Nutr Diet :
Anderson, Olivia S; Kim, Jung H; Peterson, Karen E et al. (2017) Novel Epigenetic Biomarkers Mediating Bisphenol A Exposure and Metabolic Phenotypes in Female Mice. Endocrinology 158:31-40
Afshinnia, Farsad; Zeng, Lixia; Byun, Jaeman et al. (2017) Myeloperoxidase Levels and Its Product 3-Chlorotyrosine Predict Chronic Kidney Disease Severity and Associated Coronary Artery Disease. Am J Nephrol 46:73-81
Cheung, Leonard Y M; Okano, Hideyuki; Camper, Sally A (2017) Sox21 deletion in mice causes postnatal growth deficiency without physiological disruption of hypothalamic-pituitary endocrine axes. Mol Cell Endocrinol 439:213-223
Brown, Callie L; Perrin, Eliana M; Peterson, Karen E et al. (2017) Association of Picky Eating With Weight Status and Dietary Quality Among Low-Income Preschoolers. Acad Pediatr :

Showing the most recent 10 out of 281 publications