Integrative Biostatistics and Informatics Core The Integrative Biostatistics and Informatics Core (IBIC) will provide expertise in experimental design, data management and analysis for preclinical, clinical and translational research studies conducted by MNORC Research Base investigators. The Center will continue important interactions with the Center for Computational Medicine and Bioinformatics (CCMB), the National Center for Integrative Biomedical Informatics (NCIBl), the Michigan Institute for Clinical and Health Research (MICHR) and the Biometrics and Outcomes Research Core (BORC) to provide these services. The Core will support database design for both preclinical and clinical studies. Clinically relevant databases will be Health Insurance Portability and Accountability Act (THIPAAJ compliant. The Core will also provide expertise and tools for data mining of relevant databases as well as assistance and training in the use of various tools for analysis of genomic, transcriptomic, metabolomic and proteomic data. Available tools will allow the integration and analysis of data in temporally or in relationship to phenotypic parameters collected as part of clinical studies. Finally, IBIC personnel will collaborate with ether Cores and the Investigational Weight Management Clinic to develop appropriate data formats and database constructs to integrate clinical, molecular, neurobehavioral and other phenotypic data into formats that ease analysis by biostatistical and informatics methodologies.

Public Health Relevance

The Integrative Biostatistics and Informatics Core will help design and analyze animal and human studies that utilize modern technologies aimed at understanding the causes of obesity and obesity-related diseases. The information gained from these studies may lead to new insights that will provide ways in which obesity or obesity-related diseases can be prevented or treated.

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Center Core Grants (P30)
Project #
5P30DK089503-04
Application #
8490373
Study Section
Special Emphasis Panel (ZDK1-GRB-2)
Project Start
Project End
Budget Start
2013-07-01
Budget End
2014-06-30
Support Year
4
Fiscal Year
2013
Total Cost
$159,372
Indirect Cost
$56,882
Name
University of Michigan Ann Arbor
Department
Type
DUNS #
073133571
City
Ann Arbor
State
MI
Country
United States
Zip Code
48109
Weinhouse, Caren; Sartor, Maureen A; Faulk, Christopher et al. (2016) Epigenome-wide DNA methylation analysis implicates neuronal and inflammatory signaling pathways in adult murine hepatic tumorigenesis following perinatal exposure to bisphenol A. Environ Mol Mutagen 57:435-46
Stromsdorfer, Kelly L; Yamaguchi, Shintaro; Yoon, Myeong Jin et al. (2016) NAMPT-Mediated NAD(+) Biosynthesis in Adipocytes Regulates Adipose Tissue Function and Multi-organ Insulin Sensitivity in Mice. Cell Rep 16:1851-60
Eswaran, Shanti L; Chey, William D; Han-Markey, Theresa et al. (2016) A Randomized Controlled Trial Comparing the Low FODMAP Diet vs. Modified NICE Guidelines in US Adults with IBS-D. Am J Gastroenterol 111:1824-1832
Sondhi, Varun; Owen, Bryn M; Liu, Jiayan et al. (2016) Impaired 17,20-Lyase Activity in Male Mice Lacking Cytochrome b5 in Leydig Cells. Mol Endocrinol 30:469-78
Sidahmed, ElKhansa; Sen, Ananda; Ren, Jianwei et al. (2016) Colonic Saturated Fatty Acid Concentrations and Expression of COX-1, but not Diet, Predict Prostaglandin E2 in Normal Human Colon Tissue. Nutr Cancer 68:1192-201
Sas, Kelli M; Kayampilly, Pradeep; Byun, Jaeman et al. (2016) Tissue-specific metabolic reprogramming drives nutrient flux in diabetic complications. JCI Insight 1:e86976
Chhabra, Kavaljit H; Adams, Jessica M; Jones, Graham L et al. (2016) Reprogramming the body weight set point by a reciprocal interaction of hypothalamic leptin sensitivity and Pomc gene expression reverts extreme obesity. Mol Metab 5:869-81
Morris, David L; Oatmen, Kelsie E; Mergian, Taleen A et al. (2016) CD40 promotes MHC class II expression on adipose tissue macrophages and regulates adipose tissue CD4+ T cells with obesity. J Leukoc Biol 99:1107-19
Shaeib, Faten; Khan, Sana N; Thakur, Mili et al. (2016) The Impact of Myeloperoxidase and Activated Macrophages on Metaphase II Mouse Oocyte Quality. PLoS One 11:e0151160
Greenwald-Yarnell, Megan L; Marsh, Courtney; Allison, Margaret B et al. (2016) ERα in Tac2 Neurons Regulates Puberty Onset in Female Mice. Endocrinology 157:1555-65

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