The principal goal of the Center for Polycystic Kidney Disease Research at Yale is to facilitate translational research that will advance the understanding and treatment of polycystic kidney diseases. The Center will provide investigators both at Yale and across the country with access to highly specialized services and research tools not otherwise routinely available to support their research. Three Center Cores will be established whose specific objectives are to 1) generate, maintain and provide small animal models of polycystic kidney disease, 2) provide detailed characterizations of the proteomic profiles of urine specimens derived from these mouse models during the course both of disease progression and of experimental therapies, and 3) offer polycystic kidney disease researchers access to advanced physiological tools, including characterization of ion channel activities and state of the art imaging facilities, with which to explore the cellular and molecular basis of polycystic kidney disease. We have identified a research user base of 31 investigators, including 11 at outside institutions, who have expressed specific interest in using core services of the Polycystic Kidney Disease Center at Yale. A Pilot and Feasibility Program will be established to provide initial project funding for young investigators, to attract new investigators into the field of polycystic kidney disease research, and to foster basic and translational studies directly related to polycystic kidney diseases. In addition, an Enrichment Program will be established to promote interdisciplinary interactions and collaborations among investigators participating in the Center;facilitate the application of new technologies to polycystic kidney disease research;and provide an online index of resources developed in the Center (e.g. mouse and zebrafish models and urine proteomes) so that they can be made available to polycystic kidney disease investigators both at Yale and at other institutions. The Center will also include a Research Training Program to enhance the training of graduate students, medical students, and postdoctoral fellows in polycystic kidney disease research in general, and in the specialized models and methodologies provided by the Center Cores in particular.

Public Health Relevance

Polycystic kidney disease affects more than 1 in 1,000 individuals. It is the leading genetic cause of renal failure, and 50% of polycystic kidney disease patients will require renal replacement therapy. The Center for Polycystic Kidney Disease Research at Yale will enhance polycystic kidney disease research both at Yale and across the country by offering investigators access to highly specialized services and research tools.

National Institute of Health (NIH)
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Center Core Grants (P30)
Project #
Application #
Study Section
Special Emphasis Panel (ZDK1-GRB-S (O1))
Program Officer
Flessner, Michael Francis
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
Yale University
Schools of Medicine
New Haven
United States
Zip Code
Soens, Zachry T; Li, Yuanyuan; Zhao, Li et al. (2016) Hypomorphic mutations identified in the candidate Leber congenital amaurosis gene CLUAP1. Genet Med 18:1044-51
Li, Yuanyuan; Tian, Xin; Ma, Ming et al. (2016) Deletion of ADP Ribosylation Factor-Like GTPase 13B Leads to Kidney Cysts. J Am Soc Nephrol 27:3628-3638
Kuo, Ivana Y; Duong, Sophie L; Nguyen, Lily et al. (2016) Decreased Polycystin 2 Levels Result in Non-Renal Cardiac Dysfunction with Aging. PLoS One 11:e0153632
Wang, Baisheng; Boeckel, Göran R; Huynh, Larry et al. (2016) Neuronal Calcium Sensor 1 Has Two Variants with Distinct Calcium Binding Characteristics. PLoS One 11:e0161414
Shylo, Natalia A; Christopher, Kasey J; Iglesias, Alejandro et al. (2016) TMEM107 Is a Critical Regulator of Ciliary Protein Composition and Is Mutated in Orofaciodigital Syndrome. Hum Mutat 37:155-9
Cantley, Lloyd G; Colangelo, Christopher M; Stone, Kathryn L et al. (2016) Development of a Targeted Urine Proteome Assay for kidney diseases. Proteomics Clin Appl 10:58-74
Kakade, Vijayakumar R; Tao, Shixin; Rajagopal, Madhumitha et al. (2016) A cAMP and CREB-mediated feed-forward mechanism regulates GSK3β in polycystic kidney disease. J Mol Cell Biol 8:464-476
Tao, Shixin; Kakade, Vijayakumar R; Woodgett, James R et al. (2015) Glycogen synthase kinase-3β promotes cyst expansion in polycystic kidney disease. Kidney Int 87:1164-75
Kallakuri, Sowjanya; Yu, Jianxin A; Li, Jade et al. (2015) Endothelial cilia are essential for developmental vascular integrity in zebrafish. J Am Soc Nephrol 26:864-75
Kuo, Ivana Y; Hu, Jian; Ha, Ya et al. (2015) Presenilin-like GxGD membrane proteases have dual roles as proteolytic enzymes and ion channels. J Biol Chem 290:6419-27

Showing the most recent 10 out of 30 publications