Two pre-existing functional Core Facilities will be merged under this proposal and focused on supporting the UPENN/CHOP program in benign hematopoiesis. This combined service will be entitled the Human Stem Cell Core B and will be directed by Dr. Mitchell Weiss. The two SubCores are 1) SubCore B-1, the Hematopoietic Stem Cell (HSC) Facility at UPENN, directed by Martin Carroll, and 2) SubCore B-2, the Human Embryonic Stem (ES) and Induced Pluripotent Stem (iPS) Cell Facility, which is physically present at CHOP, and will be directed by Dr. Deborah French.

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Center Core Grants (P30)
Project #
5P30DK090969-03
Application #
8378194
Study Section
Special Emphasis Panel (ZDK1-GRB-G)
Project Start
2012-07-01
Project End
2015-06-30
Budget Start
2012-07-01
Budget End
2013-06-30
Support Year
3
Fiscal Year
2012
Total Cost
$411,039
Indirect Cost
$144,037
Name
Children's Hospital of Philadelphia
Department
Type
DUNS #
073757627
City
Philadelphia
State
PA
Country
United States
Zip Code
19104
Cheng, Ying; Chikwava, Kudakwashe; Wu, Chao et al. (2016) LNK/SH2B3 regulates IL-7 receptor signaling in normal and malignant B-progenitors. J Clin Invest 126:1267-81
Sosale, Nisha G; Spinler, Kyle R; Alvey, Cory et al. (2015) Macrophage engulfment of a cell or nanoparticle is regulated by unavoidable opsonization, a species-specific 'Marker of Self' CD47, and target physical properties. Curr Opin Immunol 35:107-12
Meng, Ronghua; Wu, Jie; Harper, Dawn C et al. (2015) Defective release of ? granule and lysosome contents from platelets in mouse Hermansky-Pudlak syndrome models. Blood 125:1623-32
Reeves, D A; Gu, B W; Bessler, M et al. (2015) Variations in reactive oxygen species between mouse strains. Blood Cells Mol Dis 55:189-90
Byrska-Bishop, Marta; VanDorn, Daniel; Campbell, Amy E et al. (2015) Pluripotent stem cells reveal erythroid-specific activities of the GATA1 N-terminus. J Clin Invest 125:993-1005
Gu, Bai-Wei; Apicella, Marisa; Mills, Jason et al. (2015) Impaired Telomere Maintenance and Decreased Canonical WNT Signaling but Normal Ribosome Biogenesis in Induced Pluripotent Stem Cells from X-Linked Dyskeratosis Congenita Patients. PLoS One 10:e0127414
Wang, Yuhuan; Hayes, Vincent; Jarocha, Danuta et al. (2015) Comparative analysis of human ex vivo-generated platelets vs megakaryocyte-generated platelets in mice: a cautionary tale. Blood 125:3627-36
Ivanovska, Irena L; Shin, Jae-Won; Swift, Joe et al. (2015) Stem cell mechanobiology: diverse lessons from bone marrow. Trends Cell Biol 25:523-32
Rozenova, Krasimira; Jiang, Jing; Donaghy, Ryan et al. (2015) MERIT40 deficiency expands hematopoietic stem cell pools by regulating thrombopoietin receptor signaling. Blood 125:1730-8
Dingal, P C Dave P; Bradshaw, Andrew M; Cho, Sangkyun et al. (2015) Fractal heterogeneity in minimal matrix models of scars modulates stiff-niche stem-cell responses via nuclear exit of a mechanorepressor. Nat Mater 14:951-60

Showing the most recent 10 out of 45 publications