Exaggerated cardiovascular risk is arguably the most pressing clinical problem facing nephrologists and their patients. The causes of this preponderance of cardiovascular disease in patients with kidney disease are not clear, but hypertension amplifies cardiovascular risk and promotes progression of chronic kidney disease irrespective of the primary cause. Accordingly, the major objective of the George M. O'Brien Kidney Research Core Center at Duke is to promote and support research into understanding the unique links between the kidney, cardiovascular disease, and hypertension. The Administrative Core will be responsible for the overall administrative oversight for the Center. The Director, Dr. Thomas Coffman, will have primary responsibility for coordinating day-to-day operations. He will be assisted by the Associate Director and Center Administrator. Primary governance of the Center will be provided by an Executive Committee consisting of the Center Director, Associate Director, the Core Directors, Chair of the Pilot and Feasibility Program, and Coordinator of the Enrichment Program.
The Specific Aims of the Administrative Core are: (1) Provide general oversight of Core operations and performance;(2) Review and assign priorities to proposals for use of Core services, including: (a) establishing investigator eligibility, (b) determining scientific priorities, and (c) determining overall priorities for use of Core services;(3) Implement modifications in Core services based on development of new technologies or services, sub-optimal performance of existing technologies or services, and/or economic factors;(4) Promote interactions between the cores with an emphasis on transitioning discoveries from basic discovery projects to clinical and translational programs, (5) Assessing adequacy of resource allocation;(6) Oversight for pilot and feasibility studies to explore new areas of research relevant to the kidney in cardiovascular diseases serving as a foundation for other external funding. These funds will support new investigators, and will be used to entice senior investigators to address key issues in this thematic area;and (7) Develop education programs designed to highlight the importance of the interrelationship of kidney and cardiovascular disease, to inform Center investigators of the latest advances in relevant research, and to train investigators in clinical and basic science approaches to advance research.

Public Health Relevance

Cardiovascular disease is the major cause of death for patients with kidney disease. High blood pressure is also common, representing the second most common cause of end-stage renal disease in the US. The major objective of our proposal is to promote and support research into understanding the links between the kidney, cardiovascular disease, and hypertension.

National Institute of Health (NIH)
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Center Core Grants (P30)
Project #
Application #
Study Section
Special Emphasis Panel (ZDK1-GRB-6 (M1))
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
Duke University
United States
Zip Code
Sanna-Cherchi, Simone; Khan, Kamal; Westland, Rik et al. (2017) Exome-wide Association Study Identifies GREB1L Mutations in Congenital Kidney Malformations. Am J Hum Genet 101:789-802
Rucker, A Justin; Rudemiller, Nathan P; Crowley, Steven D (2017) Salt, Hypertension, and Immunity. Annu Rev Physiol :
Lopez-Rivera, Esther; Liu, Yangfan P; Verbitsky, Miguel et al. (2017) Genetic Drivers of Kidney Defects in the DiGeorge Syndrome. N Engl J Med 376:742-754
Wang, Liming; Sha, Yonggang; Bai, Jingyi et al. (2017) Podocyte-specific knockout of cyclooxygenase 2 exacerbates diabetic kidney disease. Am J Physiol Renal Physiol 313:F430-F439
Rudemiller, Nathan P; Crowley, Steven D (2017) The role of chemokines in hypertension and consequent target organ damage. Pharmacol Res 119:404-411
Scialla, Julia J; Asplin, John; Dobre, Mirela et al. (2017) Higher net acid excretion is associated with a lower risk of kidney disease progression in patients with diabetes. Kidney Int 91:204-215
Pun, Patrick H; Sheng, Shubin; Sanders, Gillian et al. (2017) Prescription of Guideline-Recommended Implantable Cardioverter Defibrillator and Cardiac Resynchronization Therapy Among Patients Hospitalized With Heart Failure and Varying Degrees of Renal Function. Am J Cardiol 119:886-892
Jean-Charles, Pierre-Yves; Kaur, Suneet; Shenoy, Sudha K (2017) G Protein-Coupled Receptor Signaling Through ?-Arrestin-Dependent Mechanisms. J Cardiovasc Pharmacol 70:142-158
Hall, Gentzon; Lane, Brandon; Chryst-Ladd, Megan et al. (2017) Dysregulation of WTI (-KTS) is Associated with the Kidney-Specific Effects of the LMX1B R246Q Mutation. Sci Rep 7:39933
Roberts, John K; Rao, Sunil V; Shaw, Linda K et al. (2017) Comparative Efficacy of Coronary Revascularization Procedures for Multivessel Coronary Artery Disease in Patients With Chronic Kidney Disease. Am J Cardiol 119:1344-1351

Showing the most recent 10 out of 61 publications