The Administrative Core is responsible for coordinating P30 EHS Core Center activities, including the integration of all Center components, management of day-to-day operations, program assessment, and various clerical and accounting functions. The Center in Molecular Toxicology has recently expanded into a more comprehensive organization that administers several units under a common """"""""umbrella,"""""""" as part of the new 5-year strategic plan distributed in 2006 by Vanderbilt's Associate Vice-Chancellor for Research (and current Dean of the School of Medicine), Dr J. Balser. Historically, the Center consisted of two major programs: the P30 EHS Core Center grant (this application, P30 ES000267) and the affiliated training program in environmental toxicology (T32 ES007028). Today the P30 EHS Core Center and training programs continue to provide much of the research and training infrastructure for the Center in Molecular Toxicology, but several other programs and initiatives are now included under the Center's administrative umbrella: ? Advanced Research Cooperation in Environmental Health (ARCH) with Meharry Medical College (S11 ES014156) Manganese Health Research Program (funded by the Department of Defense) ? Patient-Oriented Career Development Program (K12 ES015855), which provides support for environmental health science scholars (described in further detail, pp. 146-151) ? A newly funded NIEHS T35 short-term summer research and training program for medical students (T35 ES016534-01) ? An NIEHS Superfund Basic Research Program with Oak Ridge National Laboratory focusing on mechanisms of susceptibility to mercury toxicity (submitted 04/08). The priority score from this round was not competitive for funding, and a resubmission is planned for 04/10. ? A proposed institutionally-sponsored program in mechanisms of drug-induced cellular toxicity Thus the Administrative Core has been instrumental in leveraging resources with the goal of amplifying Vanderbilt's presence in the field of environmental toxicology as it relates to human health.

National Institute of Health (NIH)
National Institute of Environmental Health Sciences (NIEHS)
Center Core Grants (P30)
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Environmental Health Sciences Review Committee (EHS)
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Vanderbilt University Medical Center
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Minko, Irina G; Rizzo, Carmelo J; Lloyd, R Stephen (2017) Mutagenic potential of nitrogen mustard-induced formamidopyrimidine DNA adduct: contribution of the non-canonical ?-anomer. J Biol Chem :
Rivara, Matthew B; Yeung, Catherine K; Robinson-Cohen, Cassianne et al. (2017) Effect of Coenzyme Q10 on Biomarkers of Oxidative Stress and Cardiac Function in Hemodialysis Patients: The CoQ10 Biomarker Trial. Am J Kidney Dis 69:389-399
Vartanian, Vladimir; Minko, Irina G; Chawanthayatham, Supawadee et al. (2017) NEIL1 protects against aflatoxin-induced hepatocellular carcinoma in mice. Proc Natl Acad Sci U S A 114:4207-4212
Sha, Yan; Minko, Irina G; Malik, Chanchal K et al. (2017) Error-prone replication bypass of the imidazole ring-opened formamidopyrimidine deoxyguanosine adduct. Environ Mol Mutagen 58:182-189
Sugitani, Norie; Voehler, Markus W; Roh, Michelle S et al. (2017) Analysis of DNA binding by human factor xeroderma pigmentosum complementation group A (XPA) provides insight into its interactions with nucleotide excision repair substrates. J Biol Chem 292:16847-16857
Yan, H P; Roberts, L J; Davies, S S et al. (2017) Isolevuglandins as a gauge of lipid peroxidation in human tumors. Free Radic Biol Med 106:62-68
Caito, Samuel W; Aschner, Michael (2016) NAD+ Supplementation Attenuates Methylmercury Dopaminergic and Mitochondrial Toxicity in Caenorhabditis Elegans. Toxicol Sci 151:139-49
Sloan, Chantel D; Gebretsadik, Tebeb; Rosas-Salazar, Christian et al. (2016) Seasonal Timing of Infant Bronchiolitis, Apnea and Sudden Unexplained Infant Death. PLoS One 11:e0158521
Herron, Josi; Reese, Rosalyn C; Tallman, Keri A et al. (2016) Identification of Environmental Quaternary Ammonium Compounds as Direct Inhibitors of Cholesterol Biosynthesis. Toxicol Sci 151:261-70
Patra, Amritraj; Su, Yan; Zhang, Qianqian et al. (2016) Structural and Kinetic Analysis of Miscoding Opposite the DNA Adduct 1,N6-Ethenodeoxyadenosine by Human Translesion DNA Polymerase ?. J Biol Chem 291:14134-45

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