The research and development function of the MS Facility Core is to assist users with development of novel analytical methods. These generally relate to development of quantitative techniques to measure endogenous metabolites, development of methods to improve sample ionization and development of high performance UPLC methods. These internal projects are undertaken at no expense to users if they are intended to benefit a larger group of investigators and improve the technical skills of the facility core staff. The mission of the Mass Spectrometry (MS) Facility Core is to provide cost effective, state-of-the-art instrumentation and analytical expertise to Center Investigators and pilot and other supported projects in the P30 EHS Core Center This facility core is among the specialized service cores utilizing the technical personnel and instrument facilities located in the university-wide mass spectrometry facility and is used for identification, quantitation, and characterization of small molecule reaction products, e.g. eicosanoids and oxidized lipids (1-3), DNA base adducts (4-7), identification and characterization of modified oligonucleotides (8-10), and metabolic activation of xenobiotic toxicants (1, 11-13).

National Institute of Health (NIH)
National Institute of Environmental Health Sciences (NIEHS)
Center Core Grants (P30)
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Environmental Health Sciences Review Committee (EHS)
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Vanderbilt University Medical Center
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Aboud, Asad A; Tidball, Andrew M; Kumar, Kevin K et al. (2015) PARK2 patient neuroprogenitors show increased mitochondrial sensitivity to copper. Neurobiol Dis 73:204-12
Davies, Sean S; Guo, Lilu (2014) Lipid peroxidation generates biologically active phospholipids including oxidatively N-modified phospholipids. Chem Phys Lipids 181:1-33
Mullins, Elwood A; Rubinson, Emily H; Eichman, Brandt F (2014) The substrate binding interface of alkylpurine DNA glycosylase AlkD. DNA Repair (Amst) 13:50-4
Ehrmann, David C; Rose, Kristie; Calcutt, M Wade et al. (2014) Glutathionylated ?G and ?A subunits of hemoglobin F: a novel post-translational modification found in extremely premature infants by LC-MS and nanoLC-MS/MS. J Mass Spectrom 49:178-83
Stavros, Kallie M; Hawkins, Edward K; Rizzo, Carmelo J et al. (2014) Base-displaced intercalation of the 2-amino-3-methylimidazo[4,5-f]quinolone N2-dG adduct in the NarI DNA recognition sequence. Nucleic Acids Res 42:3450-63
Bowman, Aaron B; Aschner, Michael (2014) Considerations on manganese (Mn) treatments for in vitro studies. Neurotoxicology 41:141-2
Liu, Wei; Xu, Libin; Lamberson, Connor et al. (2014) A highly sensitive method for analysis of 7-dehydrocholesterol for the study of Smith-Lemli-Opitz syndrome. J Lipid Res 55:329-37
Lamberson, Connor R; Xu, Libin; Muchalski, Hubert et al. (2014) Unusual kinetic isotope effects of deuterium reinforced polyunsaturated fatty acids in tocopherol-mediated free radical chain oxidations. J Am Chem Soc 136:838-41
Brinkhaus, Sigrid Grosse; Bornhorst, Julia; Chakraborty, Sudipta et al. (2014) Elemental bioimaging of manganese uptake in C. elegans. Metallomics 6:617-21
Shuck, Sarah C; Wauchope, Orrette R; Rose, Kristie L et al. (2014) Protein modification by adenine propenal. Chem Res Toxicol 27:1732-42

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