Abstract

The research and development function of the MS Facility Core is to assist users with development of novel analytical methods. These generally relate to development of quantitative techniques to measure endogenous metabolites, development of methods to improve sample ionization and development of high performance UPLC methods. These internal projects are undertaken at no expense to users if they are intended to benefit a larger group of investigators and improve the technical skills of the facility core staff. The mission of the Mass Spectrometry (MS) Facility Core is to provide cost effective, state-of-the-art instrumentation and analytical expertise to Center Investigators and pilot and other supported projects in the P30 EHS Core Center This facility core is among the specialized service cores utilizing the technical personnel and instrument facilities located in the university-wide mass spectrometry facility and is used for identification, quantitation, and characterization of small molecule reaction products, e.g. eicosanoids and oxidized lipids (1-3), DNA base adducts (4-7), identification and characterization of modified oligonucleotides (8-10), and metabolic activation of xenobiotic toxicants (1, 11-13).

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Environmental Health Sciences (NIEHS)
Type
Center Core Grants (P30)
Project #
5P30ES000267-47
Application #
8651459
Study Section
Environmental Health Sciences Review Committee (EHS)
Project Start
Project End
Budget Start
2014-04-01
Budget End
2015-03-31
Support Year
47
Fiscal Year
2014
Total Cost
$148,098
Indirect Cost
$53,163

  Institution

Name
Vanderbilt University Medical Center
Department
Type
DUNS #
004413456
City
Nashville
State
TN
Country
United States
Zip Code
37212

  Publications

Wages, Phillip A; Kim, Hye-Young H; Korade, Zeljka et al. (2018) Identification and characterization of prescription drugs that change levels of 7-dehydrocholesterol and desmosterol. J Lipid Res 59:1916-1926
Neely, M Diana; Davison, Carrie Ann; Aschner, Michael et al. (2017) From the Cover: Manganese and Rotenone-Induced Oxidative Stress Signatures Differ in iPSC-Derived Human Dopamine Neurons. Toxicol Sci 159:366-379
Sha, Yan; Minko, Irina G; Malik, Chanchal K et al. (2017) Error-prone replication bypass of the imidazole ring-opened formamidopyrimidine deoxyguanosine adduct. Environ Mol Mutagen 58:182-189
Sugitani, Norie; Voehler, Markus W; Roh, Michelle S et al. (2017) Analysis of DNA binding by human factor xeroderma pigmentosum complementation group A (XPA) provides insight into its interactions with nucleotide excision repair substrates. J Biol Chem 292:16847-16857
Minko, Irina G; Rizzo, Carmelo J; Lloyd, R Stephen (2017) Mutagenic potential of nitrogen mustard-induced formamidopyrimidine DNA adduct: Contribution of the non-canonical ?-anomer. J Biol Chem 292:18790-18799
Rivara, Matthew B; Yeung, Catherine K; Robinson-Cohen, Cassianne et al. (2017) Effect of Coenzyme Q10 on Biomarkers of Oxidative Stress and Cardiac Function in Hemodialysis Patients: The CoQ10 Biomarker Trial. Am J Kidney Dis 69:389-399
Yan, H P; Roberts, L J; Davies, S S et al. (2017) Isolevuglandins as a gauge of lipid peroxidation in human tumors. Free Radic Biol Med 106:62-68
Deger, Serpil Muge; Hung, Adriana M; Ellis, Charles D et al. (2016) High Dose Omega-3 Fatty Acid Administration and Skeletal Muscle Protein Turnover in Maintenance Hemodialysis Patients. Clin J Am Soc Nephrol 11:1227-35
King-Morris, Kelli R; Deger, Serpil Muge; Hung, Adriana M et al. (2016) Measurement and Correlation of Indices of Insulin Resistance in Patients on Peritoneal Dialysis. Perit Dial Int 36:433-41
Lin, Ying-Chih; Owen, Nichole; Minko, Irina G et al. (2016) DNA polymerase ? limits chromosomal damage and promotes cell survival following aflatoxin exposure. Proc Natl Acad Sci U S A 113:13774-13779

Showing the most recent 10 out of 712 publications