The Proteomics Facility Core provides analytical proteomics services to investigators in the P30 EHS Core Center Analytical proteomics integrates tools for protein and peptide separations, mass spectrometry (MS) analysis, and bioinformatics to characterize proteomes and their component proteins {1-3). Proteomics is the study of proteins and proteomes, the functional complements to genomes which comprise diverse structural and functional multiprotein machines (3). Proteomics approaches offer new tools for the molecular analysis of biological systems, the identification of therapeutic targets and mechanisms, and the identification of markers for disease and therapeutic response. In the context of this P30 EHS Core Center, the Proteomics Facility Core provides essential support for the characterization of chemical modification of proteins, including protein adducts derived from xenobiotics and reactive intermediates generated in situ, as well as regulatory post-translational modifications (4). The Proteomics Facility Core also provides essential support for the identification of interacting partners of proteins in multiprotein complexes, as well as analyses of complex proteomes and subproteomes. Research Interactions The Proteomics Core also provides a research technology platform for more elaborate, challenging, and advanced studies that require customized experimental designs, analytical approaches, and expertise. These """"""""research functions"""""""" of the core are defined as those analytical tasks that fall outside the usual scope of the fee-for-service functions and require the sustained interaction of a Center Investigator's laboratory with a Proteomics Associate Director and skilled staff supported by the Proteomics Facility Core component of the Center grant. Because the following research services may involve an open-ended commitment of time by Core faculty, professional effort will be recorded and traced to individual projects so that no single investigator places an undue burden on the professional staff in excess of the support provided by the P30 EHS Core Center For examples of past research interactions of Center Investigators in the Proteomics Facility Core, see the Progress Report section, pp. 304-311.

National Institute of Health (NIH)
National Institute of Environmental Health Sciences (NIEHS)
Center Core Grants (P30)
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Environmental Health Sciences Review Committee (EHS)
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Vanderbilt University Medical Center
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Deger, Serpil Muge; Hung, Adriana M; Ellis, Charles D et al. (2016) High Dose Omega-3 Fatty Acid Administration and Skeletal Muscle Protein Turnover in Maintenance Hemodialysis Patients. Clin J Am Soc Nephrol 11:1227-35
King-Morris, Kelli R; Deger, Serpil Muge; Hung, Adriana M et al. (2016) Measurement and Correlation of Indices of Insulin Resistance in Patients on Peritoneal Dialysis. Perit Dial Int 36:433-41
Sloan, Chantel D; Gebretsadik, Tebeb; Rosas-Salazar, Christian et al. (2016) Seasonal Timing of Infant Bronchiolitis, Apnea and Sudden Unexplained Infant Death. PLoS One 11:e0158521
Ware, Lorraine B; Zhao, Zhiguo; Koyama, Tatsuki et al. (2016) Long-Term Ozone Exposure Increases the Risk of Developing the Acute Respiratory Distress Syndrome. Am J Respir Crit Care Med 193:1143-50
Minko, Irina G; Jacobs, Aaron C; de Leon, Arnie R et al. (2016) Catalysts of DNA Strand Cleavage at Apurinic/Apyrimidinic Sites. Sci Rep 6:28894
Patra, Amritraj; Su, Yan; Zhang, Qianqian et al. (2016) Structural and Kinetic Analysis of Miscoding Opposite the DNA Adduct 1,N6-Ethenodeoxyadenosine by Human Translesion DNA Polymerase η. J Biol Chem 291:14134-45
Wakeman, Catherine A; Moore, Jessica L; Noto, Michael J et al. (2016) The innate immune protein calprotectin promotes Pseudomonas aeruginosa and Staphylococcus aureus interaction. Nat Commun 7:11951
Denny, Gerald B; Deger, Serpil M; Chen, Guanhua et al. (2016) Leucine disposal rate for assessment of amino acid metabolism in maintenance hemodialysis patients. BMC Nutr 2:
Shimada, Tsutomu; Takenaka, Shigeo; Murayama, Norie et al. (2016) Oxidation of pyrene, 1-hydroxypyrene, 1-nitropyrene and 1-acetylpyrene by human cytochrome P450 2A13. Xenobiotica 46:211-24
Brosey, Chris A; Soss, Sarah E; Brooks, Sonja et al. (2015) Functional dynamics in replication protein A DNA binding and protein recruitment domains. Structure 23:1028-38

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