The overall goal of the IHSFC is to facilitate both patient-oriented and population-based research directed at studies of the etiology, pathogenesis, and prognosis of disease in patient populations, and to integrate this work with the strong basic science programs within the Center in Molecular Toxicology.
Aim 1. To stimulate and support both clinical and translational research, including patient-oriented and population-based research, within the Vanderbilt P30 EHS Core Center by expanding existing research projects and fostering new interdisciplinary activities focusing on environmental health problems.
Aim 2. To describe the development process, infrastructure and outcomes of the IHFSC in order to not only create, but optimize and be a successful example of developing a core infrastructure and environment for interdisciplinary science both for the purposes of conducting interdisciplinary research, as well as for training new interdisciplinary scientists both among the ranks of established investigators, as well as among trainees.

Agency
National Institute of Health (NIH)
Institute
National Institute of Environmental Health Sciences (NIEHS)
Type
Center Core Grants (P30)
Project #
5P30ES000267-47
Application #
8651461
Study Section
Environmental Health Sciences Review Committee (EHS)
Project Start
Project End
Budget Start
2014-04-01
Budget End
2015-03-31
Support Year
47
Fiscal Year
2014
Total Cost
$427,753
Indirect Cost
$153,553
Name
Vanderbilt University Medical Center
Department
Type
DUNS #
004413456
City
Nashville
State
TN
Country
United States
Zip Code
37212
Minko, Irina G; Rizzo, Carmelo J; Lloyd, R Stephen (2017) Mutagenic potential of nitrogen mustard-induced formamidopyrimidine DNA adduct: contribution of the non-canonical ?-anomer. J Biol Chem :
Rivara, Matthew B; Yeung, Catherine K; Robinson-Cohen, Cassianne et al. (2017) Effect of Coenzyme Q10 on Biomarkers of Oxidative Stress and Cardiac Function in Hemodialysis Patients: The CoQ10 Biomarker Trial. Am J Kidney Dis 69:389-399
Vartanian, Vladimir; Minko, Irina G; Chawanthayatham, Supawadee et al. (2017) NEIL1 protects against aflatoxin-induced hepatocellular carcinoma in mice. Proc Natl Acad Sci U S A 114:4207-4212
Sha, Yan; Minko, Irina G; Malik, Chanchal K et al. (2017) Error-prone replication bypass of the imidazole ring-opened formamidopyrimidine deoxyguanosine adduct. Environ Mol Mutagen 58:182-189
Sugitani, Norie; Voehler, Markus W; Roh, Michelle S et al. (2017) Analysis of DNA binding by human factor xeroderma pigmentosum complementation group A (XPA) provides insight into its interactions with nucleotide excision repair substrates. J Biol Chem 292:16847-16857
Yan, H P; Roberts, L J; Davies, S S et al. (2017) Isolevuglandins as a gauge of lipid peroxidation in human tumors. Free Radic Biol Med 106:62-68
Caito, Samuel W; Aschner, Michael (2016) NAD+ Supplementation Attenuates Methylmercury Dopaminergic and Mitochondrial Toxicity in Caenorhabditis Elegans. Toxicol Sci 151:139-49
Sloan, Chantel D; Gebretsadik, Tebeb; Rosas-Salazar, Christian et al. (2016) Seasonal Timing of Infant Bronchiolitis, Apnea and Sudden Unexplained Infant Death. PLoS One 11:e0158521
Herron, Josi; Reese, Rosalyn C; Tallman, Keri A et al. (2016) Identification of Environmental Quaternary Ammonium Compounds as Direct Inhibitors of Cholesterol Biosynthesis. Toxicol Sci 151:261-70
Patra, Amritraj; Su, Yan; Zhang, Qianqian et al. (2016) Structural and Kinetic Analysis of Miscoding Opposite the DNA Adduct 1,N6-Ethenodeoxyadenosine by Human Translesion DNA Polymerase ?. J Biol Chem 291:14134-45

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