Abstract

The overall objective of the Animal Models Facilities Core (AMFC) is to provide Center members with state-of-the-art pathology support, transgenic resources and a centrally managed AAALAC-approved animal resource and surgical facility. The Core is staffed with experienced personnel and is equipped with essential equipment to generate genetically engineered mice, rederive imported mice by embryo transfer rederivation, provide colony management, develop surgical models and prepare and interpret tissue samples by histological and immunohistochemistry analysis.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Environmental Health Sciences (NIEHS)
Type
Center Core Grants (P30)
Project #
5P30ES002109-32
Application #
8375046
Study Section
Environmental Health Sciences Review Committee (EHS)
Project Start
Project End
Budget Start
2012-05-04
Budget End
2013-03-31
Support Year
32
Fiscal Year
2012
Total Cost
$234,773
Indirect Cost
$90,739

  Institution

Name
Massachusetts Institute of Technology
Department
Type
DUNS #
001425594
City
Cambridge
State
MA
Country
United States
Zip Code
02139

  Publications

Freedman, Adam J E; Peet, Kyle C; Boock, Jason T et al. (2018) Isolation, Development, and Genomic Analysis of Bacillus megaterium SR7 for Growth and Metabolite Production Under Supercritical Carbon Dioxide. Front Microbiol 9:2152
Dudani, Jaideep S; Ibrahim, Maria; Kirkpatrick, Jesse et al. (2018) Classification of prostate cancer using a protease activity nanosensor library. Proc Natl Acad Sci U S A 115:8954-8959
Nakashige, Toshiki G; Bowman, Sarah E J; Zygiel, Emily M et al. (2018) Biophysical Examination of the Calcium-Modulated Nickel-Binding Properties of Human Calprotectin Reveals Conformational Change in the EF-Hand Domains and His3Asp Site. Biochemistry 57:4155-4164
Ganesh, B P; Hall, A; Ayyaswamy, S et al. (2018) Diacylglycerol kinase synthesized by commensal Lactobacillus reuteri diminishes protein kinase C phosphorylation and histamine-mediated signaling in the mammalian intestinal epithelium. Mucosal Immunol 11:380-393
Bauwens, Eva; Joosten, Myrthe; Taganna, Joemar et al. (2018) In silico proteomic and phylogenetic analysis of the outer membrane protein repertoire of gastric Helicobacter species. Sci Rep 8:15453
Lo, Justin H; Hao, Liangliang; Muzumdar, Mandar D et al. (2018) iRGD-guided Tumor-penetrating Nanocomplexes for Therapeutic siRNA Delivery to Pancreatic Cancer. Mol Cancer Ther 17:2377-2388
Richardson, Christopher E R; Cunden, Lisa S; Butty, Vincent L et al. (2018) A Method for Selective Depletion of Zn(II) Ions from Complex Biological Media and Evaluation of Cellular Consequences of Zn(II) Deficiency. J Am Chem Soc 140:2413-2416
Hagen, Susan J; Ang, Lay-Hong; Zheng, Yi et al. (2018) Loss of Tight Junction Protein Claudin 18 Promotes Progressive Neoplasia Development in Mouse Stomach. Gastroenterology 155:1852-1867
Viswanathan, Srinivas R; Nogueira, Marina F; Buss, Colin G et al. (2018) Genome-scale analysis identifies paralog lethality as a vulnerability of chromosome 1p loss in cancer. Nat Genet 50:937-943
Co, Julia Y; Cárcamo-Oyarce, Gerardo; Billings, Nicole et al. (2018) Mucins trigger dispersal of Pseudomonas aeruginosa biofilms. NPJ Biofilms Microbiomes 4:23

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